Results 11 to 20 of about 137,964 (298)
Sonic hedgehog signaling in astrocytes [PDF]
Cellular and Molecular Life Sciences, 2020 Astrocytes are complex cells that perform a broad array of essential functions in the healthy and injured nervous system. The recognition that these cells are integral components of various processes, including synapse formation, modulation of synaptic ...
S. Hill, Marissa Fu, A. D. R. Garcia
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Sonic Hedgehog Signaling and Tooth Development [PDF]
International Journal of Molecular Sciences, 2020 Sonic hedgehog (Shh) is a secreted protein with important roles in mammalian embryogenesis. During tooth development, Shh is primarily expressed in the dental epithelium, from initiation to the root formation stages. A number of studies have analyzed the
A. Hosoya +4 more
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Sonic Hedgehog Signaling in Limb Development [PDF]
Frontiers in Cell and Developmental Biology, 2017 The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the posterior margin of the vertebrate limb bud. Detailed analyses have revealed that
C. Tickle, M. Towers
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Sonic Hedgehog Signaling and Development of the Dentition [PDF]
Journal of Developmental Biology, 2017 Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates.
M. Seppala +4 more
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Sonic Hedgehog Signaling in Thyroid Cancer [PDF]
Frontiers in Endocrinology, 2017 Thyroid cancer is the most common malignancy of the endocrine system. The initiation of thyroid cancer is often triggered by a genetic mutation in the phosphortidylinositol-3 kinase (PI3K) or mitogen-activated protein kinase (MAPK) pathway, such as RAS ...
Xiulong Xu +4 more
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Probing extracellular Sonic hedgehog in neurons [PDF]
Biology Open, 2016 The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in ...
Erez Eitan +5 more
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Germline Elongator mutations in Sonic Hedgehog medulloblastoma [PDF]
Nature, 2020 Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children1,2, and genetic events that cooperate with known somatic driver events are poorly understood ...
Sebastian M. Waszak +62 more
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Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
Biomedicines, 2022 Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning.
Priyadharshini Manikandan +2 more
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Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments
International Journal of Molecular Sciences, 2020 During mammalian embryonic development, primary cilia transduce and regulate several signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most significant. SHH signaling remains quiescent in adult mammalian tissues. However,
K. Jeng, Chiung-Fang Chang, Shuru Lin
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