Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.
PLoS ONE, 2013 In this study, we examined the expression of Sonic Hedgehog, Patched, Gli1, Gli2, Gli3 and Myocardin in the developing bladders of male and female normal and megabladder (mgb-/-) mutant mice at embryonic days 12 through 16 by in situ hybridization.
Kristin R DeSouza +4 more
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Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy2 expression in the chick limb [PDF]
, 2012 Embryo development requires precise orchestration of cell proliferation and differentiation in both time and space. A molecular clock operating through gene expression oscillations was first described in the presomitic mesoderm (PSM) underlying periodic ...
Andrade, Raquel P. +2 more
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Sonic hedgehog pathway expression in non-small cell lung cancer
Therapeutic Advances in Medical Oncology, 2012 Objective: Activation of the hedgehog pathway is an important signaling mechanism crucial in embryogenesis and has strong links to carcinogenesis. This study investigates the expression of the Sonic hedgehog pathway molecules in non-small cell lung ...
Malvi Savani +3 more
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Hedgehog Signalling in Androgen Independent Prostate Cancer [PDF]
, 2008 Objectives: Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis.
Bisson, Isabelle +7 more
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Lipid metabolism fattens up hedgehog signaling
BMC Biology, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg, John Jacob
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Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]
, 2016 Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C +6 more
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Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. [PDF]
, 2015 Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive ...
Berezov, A +17 more
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Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin. [PDF]
PLoS ONE, 2012 Oligodendrocyte differentiation is temporally regulated during development by multiple factors. Here, we investigated whether the timing of oligodendrocyte differentiation might be controlled by neuronal differentiation in cerebellar organotypic cultures.
Lamia Bouslama-Oueghlani +8 more
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In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]
, 2016 Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R. +13 more
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Activation of the hedgehog pathway in advanced prostate cancer
Molecular Cancer, 2004 Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank +8 more
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