Results 41 to 50 of about 137,964 (298)
Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
Cell Regeneration, 2023 The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang +7 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SHH (Sonic hedgehog), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
Sonic Hedgehog signaling in the mammalian brain [PDF]
Journal of Neurochemistry, 2010 J. Neurochem. (2010) 113, 576–590.AbstractThe discovery of a Sonic Hedgehog (Shh) signaling pathway in the mature vertebrate CNS has paved the way to the characterization of the functional roles of Shh signals in normal and diseased brain. Shh is proposed to participate in the establishment and maintenance of adult neurogenic niches and to regulate ...
Traiffort, Elisabeth +2 more
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Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
Cancers, 2016 The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma ...
Tadas K. Rimkus +4 more
semanticscholar +1 more source
Sonic hedgehog expression in the postnatal brain [PDF]
Biology Open, 2019 Beyond its role in patterning the neural tube during embryogenesis, additional functions of Sonic hedgehog (Shh) in post-embryonic and mature brains have been coming into focus. However, the question of the abundance of endogenous Shh – the ligand of the signaling pathway – and its changes over time in post-embryonic and mature brains are less well ...
Aileen Rivell +6 more
openaire +4 more sources
Sonic hedgehog pathway expression in non-small cell lung cancer
Therapeutic Advances in Medical Oncology, 2012 Objective: Activation of the hedgehog pathway is an important signaling mechanism crucial in embryogenesis and has strong links to carcinogenesis. This study investigates the expression of the Sonic hedgehog pathway molecules in non-small cell lung ...
Malvi Savani +3 more
doaj +1 more source
Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin. [PDF]
PLoS ONE, 2012 Oligodendrocyte differentiation is temporally regulated during development by multiple factors. Here, we investigated whether the timing of oligodendrocyte differentiation might be controlled by neuronal differentiation in cerebellar organotypic cultures.
Lamia Bouslama-Oueghlani +8 more
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Frontiers in Cellular and Infection Microbiology, 2022 ObjectivesTo investigate the pathogenic effect of Porphyromonas gingivalis cultured media on the esophagus and the mechanism underlying the effect.BackgroundPeriodontitis is strongly associated with esophageal squamous cell carcinoma (ESCC). The cultured
Xueting Jia +7 more
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Lipid metabolism fattens up hedgehog signaling
BMC Biology, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg, John Jacob
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TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source