Results 51 to 60 of about 137,964 (298)
Structural basis for the recognition of Sonic Hedgehog by human Patched1
Science, 2018 The first step in Hedgehog signaling The Hedgehog (Hh) signaling pathway is important in embryogenesis; overactivation is associated with cancer. Central to the pathway is the membrane receptor Patched 1 (Ptch1), which indirectly inhibits a G protein ...
X. Gong +6 more
semanticscholar +1 more source
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism
Nature Chemical Biology, 2019 Hedgehog (HH) ligands, classical morphogens that pattern embryonic tissues in all animals, are covalently coupled to two lipids—a palmitoyl group at the N terminus and a cholesteroyl group at the C terminus.
A. F. Rudolf +16 more
semanticscholar +1 more source
Sonic hedgehog signaling in craniofacial development. [PDF]
Differentiation, 2023 Mutations in SHH and several other genes encoding components of the Hedgehog signaling pathway have been associated with holoprosencephaly syndromes, with craniofacial anomalies ranging in severity from cyclopia to facial cleft to midfacial and mandibular hypoplasia.
Xu J, Iyyanar PPR, Lan Y, Jiang R.
europepmc +3 more sources
Epithelial Trafficking of Sonic Hedgehog by Megalin [PDF]
Journal of Histochemistry & Cytochemistry, 2006 We present here evidence of in vivo epithelial endocytosis and trafficking of non-lipid-modified Sonic hedgehog (ShhN) when infused into rat efferent ducts via microinjection. Initially, exogenous ShhN is detected in endocytic vesicles and early endosomes located near the apical plasma membrane of non-ciliated cells.
Carlos R. Morales +7 more
openaire +3 more sources
Targeted therapy done right: Direct sonic hedgehog inhibition for sonic hedgehog medulloblastoma. [PDF]
Neuro OncolNellan A, Jackson S.
europepmc +3 more sources
Sonic hedgehog signaling in the postnatal brain [PDF]
Seminars in Cell & Developmental Biology, 2014 Sonic hedgehog (Shh) is a pleiotropic factor in the developing central nervous system (CNS), driving proliferation, specification, and axonal targeting in multiple sites within the forebrain, hindbrain, and spinal cord. Studies in embryonic CNS have shown how gradients of this morphogen are translated by neuroepithelial precursors to determine the ...
Álvarez-Buylla, Arturo, Ihrie, Rebecca
openaire +5 more sources
Sonic Hedgehog Signaling and Hippocampal Neuroplasticity [PDF]
Trends in Neurosciences, 2016 Sonic hedgehog (Shh) is a secreted protein that controls the patterning of neural progenitor cells, and their neuronal and glial progeny, during development. Emerging findings suggest that Shh also has important roles in the formation and plasticity of neuronal circuits in the hippocampus, a brain region of fundamental importance in learning and memory.
P. Yao, R. Petralia, M. Mattson
semanticscholar +4 more sources
Frontiers in Endocrinology, 2022 The palmitoylation of the Hedgehog (Hh) family of morphogens, named sonic hedgehog (SHH), desert hedgehog (DHH), and Indian hedgehog (IHH), is crucial for effective short- and long-range signaling.
Noelia Baz-Redón +18 more
doaj +1 more source
Regulation of Thalamic Development by Sonic Hedgehog [PDF]
Frontiers in Neuroscience, 2012 The thalamus is strategically positioned within the caudal diencephalic area of the forebrain, between the mesencephalon and telencephalon. This location is important for unique aspects of thalamic function, to process and relay sensory and motor information to and from the cerebral cortex.
openaire +4 more sources
Sonic hedgehog and CDX2 expression in the stomach [PDF]
Journal of Gastroenterology and Hepatology, 2008 AbstractSonic hedgehog (Shh) is an essential regulator of patterning processes throughout development, and CDX proteins act as the master regulators for intestinal development and differentiation. Shh and CDX2 seem to be interdependently linked with cellular differentiation through different signal cascades.
Tomoari Kamada +6 more
openaire +3 more sources