Results 61 to 70 of about 137,964 (298)
Activation of the hedgehog pathway in advanced prostate cancer
Molecular Cancer, 2004 Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank +8 more
doaj +1 more source
Cell Death and Disease, 2021 Motoneuronal loss is the main feature of amyotrophic lateral sclerosis, although pathogenesis is extremely complex involving both neural and muscle cells.
Nunzio Vicario +22 more
doaj +1 more source
The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots
Advanced Science, EarlyView.DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya +6 more
wiley +1 more source
Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond
International Journal of Molecular Sciences, 2018 Sonic hedgehog (Shh), a member of the hedgehog (Hh) family, was originally recognized as a morphogen possessing critical characters for neural development during embryogenesis.
Shang-Der Chen +3 more
semanticscholar +1 more source
Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function
Biology Open, 2014 Holoprosencephaly is a heterogeneous developmental malformation of the central nervous system characterized by impaired forebrain cleavage, midline facial anomalies and wide phenotypic variation.
Maisa Seppala +3 more
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Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Sonic hedgehog in vertebrate neural tube development.
International Journal of Developmental Biology, 2018 The formation and wiring of the vertebrate nervous system involves the spatially and temporally ordered production of diverse neuronal and glial subtypes that are molecularly and functionally distinct.
M. Placzek, J. Briscoe
semanticscholar +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Sonic hedgehog as a chemoattractant for adult NPCs [PDF]
Cell Adhesion & Migration, 2010 The developmental morphogen Sonic hedgehog (Shh) is well known for its role in modulating the proliferation and survival of neural progenitor cells in the developing mouse brain. A recent report now showed that Shh could regulate the migration of neuroblast in the adult subventricular zone (SVZ) along the rostral migratory stream (RMS) to the olfactory
Bor Luen Tang, Catherine Hong Huan Hor
openaire +3 more sources
Molecular classification of hepatocellular adenomas: impact on clinical practice
Hepatic Oncology, 2018 Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10–20%) and malignant transformation into hepatocellular carcinoma (
Anne-Laure Védie +3 more
doaj +1 more source