Results 91 to 100 of about 26,431 (247)

257 -- Localization of the Sonic the Hedgehog (Shh) protein in Zebrafish retinas

, 2022
Unlike most vertebrates, zebrafish possess the unique ability to regenerate organ tissues and retinas when damaged. Understanding this regenerative process could be the key to assisting in preventing and healing damaged retinal cells in humans. Zebrafish
Pitcher, Mackenzie, Barbosa, Jack, Miller, Levi   +2 more
core  

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate

EvoDevo, 2018
Background The notochord has organizer properties and is required for floor plate induction and dorsoventral patterning of the neural tube. This activity has been attributed to sonic hedgehog (shh) signaling, which originates in the notochord, forms a ...
Stanislav Kremnyov, Kristine Henningfeld, Christoph Viebahn, Nikoloz Tsikolia   +3 more
doaj   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

, 2007
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E, Rowbotham, NJ, Crompton, T, Dyson, J, Shah, DK, Cebecauer, M, Hager-Theodorides, AL, Outram, SV   +7 more
core  

Sonic hedgehog promotes autophagy in hippocampal neurons [PDF]

, 2013
Summary The Sonic hedgehog (Shh) signaling pathway is well known in patterning of the neural tube during embryonic development, but its emerging role in differentiated neurons is less understood.
Catherine M. Schwartz, Ya-Xian Wang, Mark P. Mattson, Ronald S. Petralia, Elisa M. Kawamoto, Pamela J. Yao   +5 more
core   +1 more source

Occurrence of multiple congenital anomalies in Potamotrygon amandae (Elasmobranchii, Potamotrygoninae) embryos, including the first report of bicephaly

Journal of Fish Biology, EarlyView.
Abstract Reports of teratogenic embryos in elasmobranchs have been documented in multiple species, with proposed aetiologies including environmental disturbances, genetic mutations, predation, exposure to endocrine‐disrupting compounds and maternal stress.
Douglas de Castro Ribeiro, Raquel Lopes Queiroz, Cristiéle da Silva Ribeiro   +2 more
wiley   +1 more source

The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts

, 2009
The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer.
Aubie Shaw, Jerry Gipp, Wade Bushman
core  

Supplementary Material for: Differential Modulation of Sonic-Hedgehog-Induced Cerebellar Granule Cell Precursor Proliferation by the IGF Signaling Network

, 2017
The molecular mechanisms regulating organ growth and size remain unclear. Sonic hedgehog (SHH) signaling is a major player in the regulation of cerebellar development: SHH is secreted by Purkinje neurons and acts on the proliferation of granule cell ...
Bertrand N. (4121647), Fernandez C. (4121644), Dahmane N. (4121638), Tatard V.M. (4121641)   +3 more
core   +1 more source

Sonic hedgehog (Shh)/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum [PDF]

, 2012
Background: Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of
Melina Rapacioli, Flores, Vladimir, Joao Botelho, Elliot, Matías, Gustavo Cerda, Vladimir Flores, Santiago Duarte, Botelho, Joao, Duarte, Santiago, Rapacioli, Melina, Palma, Verónica, Matías Elliot, Cerda, Gustavo, Verónica Palma   +13 more
core   +1 more source