Results 101 to 110 of about 26,431 (247)

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, EarlyView.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life

Journal of Developmental Biology, 2018
Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic ...
Henk Roelink
doaj   +1 more source

ALKAL1 gene silencing prevents colorectal cancer progression via suppressing Sonic Hedgehog (SHH) signaling pathway. [PDF]

J Cancer, 2021
Chen S, Wang B, Fu X, Liang Y, Chai X, Ye Z, Li R, He Y, Kong G, Lian J, Li X, Chen T, Zhang X, Qiu X, Tang X, Zhou K, Lin B, Zeng J.   +17 more
europepmc   +1 more source

Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source [PDF]

, 2013
The Sonic Hedgehog (Shh) pathway is responsible for critical patterning events early in development and for regulating the delicate balance between proliferation and differentiation in the developing and adult vertebrate brain.
Solis, Natalia P., Lois, Pablo, Wainwright, Brandon J., Palma, Veronica, Ellis, Tammy, Constanza Martínez (420465), Verónica Palma (420469), Brandon J Wainwright, Hugo Cornejo, Victor, Natalia P. Solis (420468), Constanza Martínez, Tammy Ellis (229977), Víctor Hugo Cornejo, Tammy Ellis, Víctor Hugo Cornejo (420466), Cornejo, Víctor Hugo, Natalia P Solis, Brandon J. Wainwright (229991), Pablo Lois (420467), Verónica Palma, Palma Alvarado, Verónica, Martinez, Constanza, Pablo Lois   +22 more
core   +1 more source

The association between 331A/T polymorphism in the SHH gene and 385G/A polymorphism in the SMO gene and the development of basal cell carcinomas

Przegląd Dermatologiczny, 2014
Introduction. Basal cell carcinomas (BCCs) are the most common of all cancers in the Caucasians, and their incidence has been rising in younger populations.
Dorota Sobolewska-Sztychny, Joanna Narbutt, Michał Sobjanek, Karolina Wódz, Joanna Sieniawska, Anna Woźniacka, Aleksandra Lesiak   +6 more
doaj   +1 more source

Role of sonic hedgehog in branchiomotor neuron induction in zebrafish

, 1998
The role of zebrafish hedgehog genes in branchiomotor neuron development was analyzed by examining mutations that affect the expression of the hedgehog genes and by overexpressing these genes in embryos.
Schauerte, H., Warren Jr, J., Haffter, P., Takahashi, K., van Eeden, F. ; https://orcid.org/, Kuwada, J., Chandrasekhar, A.   +6 more
core   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Regulates Competition Dependent Astrocyte Morphogenesis and Tiling in Murine Cortex

Glia, Volume 74, Issue 8, August 2026.
Neuronal contact‐induced expression of S1PR1 in astrocytes is regulated by JAK‐STAT3 signaling. Astrocytic S1PR1 modulates cortical astrocyte morphogenesis. Astrocytic S1PR1 regulates astrocyte territorial overlap/tiling in a competition dependent manner.
Jean Patrick M. Gonzales, Connor Tuck, Surya Chandra Rao Thumu, Soha Munir, Jaden Harris, Hunain (Zeik) Tariq, Paul Marcelli, Oscar Dominguez, Kaviya Suriyakumar Anbazagan, Sandeep K. Singh   +9 more
wiley   +1 more source

CMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis

Oncogenesis
Aberrant Hedgehog signaling is a key driver of malignancies like medulloblastoma (MB), the most common pediatric brain tumor originating from cerebellar granule neuron progenitors with largely uncharacterized mechanisms.
Shan Wang, Tongtong Jiang, Tao Wang, Zhiwei Yang, Ting Wang, Xiao Zhang, Xingchun Gou, Lintao Jia, Liang Wang, Yang Song   +9 more
doaj   +1 more source

Integrated molecular analysis of adult sonic hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator. [PDF]

Neuro Oncol, 2021
Korshunov A, Okonechnikov K, Stichel D, Ryzhova M, Schrimpf D, Sahm F, Sievers P, Absalyamova O, Zheludkova O, Golanov A, Jones DTW, Pfister SM, von Deimling A, Kool M.   +13 more
europepmc   +1 more source

In vitro cell culture systems for the investigation of the morphogen Sonic hedgehog (Shh) [PDF]

, 2011
Sonic hedgehog (Shh) plays an important role in embryogenesis. It acts as a morphogen that diffuses to form a concentration gradient and works in a temporally and spatially controlled manner. Shh not only regulates organogenesis, such as formation of digits on limbs and organization of the brain, but also controls cell division of stem cells ...
openaire   +1 more source