Results 111 to 120 of about 26,431 (247)
Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells
, 2002 Sonic Hedgehog is a secreted morphogen involved in patterning a wide range of structures in the developing embryo. Disruption of the Hedgehog signalling cascade leads to a number of developmental disorders and plays a key role in the formation of a range
Forrest, A. R. +9 more
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Etymology and entomology: The semiotics and ethics of multispecies gene nomenclatures
Journal of Linguistic Anthropology, Volume 36, Issue 2, August 2026.Abstract This article examines controversies surrounding gene names that are perceived as humorous in the context of fruit flies but are considered rude in the clinical context of human medicine. Drawing on ethnographic fieldwork in insect laboratories, interviews with entomologists and geneticists, and an analysis of scientific and clinical ...
Colin M. E. Halverson
wiley +1 more source
, 2015 Cell fate specification requires tightly orchestrated cellular responses to extracellular factors. In this issue of Developmental Cell, Kong et al. (2015) reveal that Notch signaling activity facilitates the interpretation of Sonic hedgehog (Shh) signals
Yoon, Keejung +2 more
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Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
PLoS ONE, 2014 Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis. Some in vitro and animal studies has already proven its potential for bone regeneration.
Stefan Eipeldauer +7 more
openaire +4 more sources
Sonic Hedgehog: a lipid speciated hormone?
, 2015 In the past two decades, the Hedgehog (HH) family of secreted proteins has been demonstrated to play an essential role in both animal development and various human diseases [1].
Robbins, David J +5 more
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Aging Cell, Volume 25, Issue 7, July 2026.This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang +6 more
wiley +1 more source
Genome-wide analysis of gene expression and alternative splicing in human medulloblastoma
, 2010 Medulloblastoma is a malignant embryonal tumour of the cerebellum which most commonly affects children. A subset of tumours is thought to arise from cerebellar granule cell precursors (GCPs) that fail to undergo normal neuronal development, following ...
Menghi, F.
core
Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia
Clinical Genetics, Volume 110, Issue 1, Page 3-14, July 2026.Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise +5 more
wiley +1 more source
Exploring new targeted therapies for Sonic Hedgehog (SHH) medulloblastoma
, 2022 Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor and is currently divided into 4 molecular subgroups that exhibit different genomic alterations, gene expression profiles and response to treatment. We have previously shown a novel role for the MEK/MAPK pathway in specifically contributing to Sonic Hedgehog (SHH) MB tumor ...
openaire +1 more source