Results 131 to 140 of about 26,431 (247)

Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells with the presence of lipopolysaccharides, tumor necrosis factor-alpha, or interferons

, 2014
Due to the development of drug resistance, the outcome for the majority of patients with acute myeloid leukemia (acute myelogenous leukemia; AML) remains poor.
Lu, Frank Leigh;Yu, Ching-Chia;Chiu, Huei-Hsuan;Liu, Hsingjin Eugene;Chen, Shao-Yin;Lin, Shufan;Goh, Ting-Yi;Hsu, Hsin-Chih;Chien, Chih-Han;Wu, Han-Chung;Chen, Ming-Shan;Schuyler, Scott C.;Hsieh, Wu-Shiun;Wu, Mei-Hwan;Lu, Jean, 謝武勳 ;吳美環 ;呂立   +1 more
core  

3D Chromatin Regulation of Sonic Hedgehog in the Limb Buds

, 2009
Understanding the mechanisms that regulate gene expression during development is a major challenge in science. In this issue of Developmental Cell, Amano and colleagues report that expression of Sonic hedgehog (Shh) protein in the posterior mesenchyme of
Ferrai, Carmelo, Pombo, Ana, Ferrai, C., Pombo, A.   +3 more
core   +1 more source

Odontogenic Keratocysts Don't Harbor BRAF Mutation: A Genetic and Immunohistochemical Analysis

Oral Diseases, EarlyView.
Raisa Severino‐Lazo, Jéssica da Silva Cunha, Allan Vinícius Martins‐de‐Barros, Karina Helen Martins, Adauto Gomes Barbosa Neto, Jorge Esquiche León, Marianne de Vasconcelos Carvalho   +6 more
wiley   +1 more source

Social and Anxiety‐Like Behaviors Are Affected in Juvenile Mice With Gli2+/− but Not Gli3+/𝛥699 Genetic Modifications

Brain and Behavior, Volume 16, Issue 6, June 2026.
Across Gli3+/Δ699, Gli2+/−, and combined Gli2+/−;Gli3+/Δ699 mice (males and females, with wild‐type controls), GLI2 and GLI3 differentially regulate anogenital distance and juvenile behavior, with amplified effects under combined disruption, whereas circulating steroids and sexually dimorphic nucleus area remain unchanged. Created in BioRender. Niepsuj,
Thomas Niepsuj, Rithika Nurani, Leykza Carreras‐Simons, Wade Bushman, Joan S. Jorgensen, Walid A. Farhat, Anthony P. Auger   +6 more
wiley   +1 more source

Correction: Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source. [PDF]

PLoS One, 2020
Martínez C, Cornejo VH, Lois P, Ellis T, Solis NP, Wainwright BJ, Palma V.   +6 more
europepmc   +1 more source

Sonic hedgehog signaling in spinal cord contributes to morphine-induced hyperalgesia and tolerance through upregulating brain-derived neurotrophic factor expression

, 2018
Su Liu,1,2,* Jun-Li Yao,1,3,* Xin-Xin Wan,1,* Zhi-Jing Song,1 Shuai Miao,1,2 Ye Zhao,1,2 Xiu-Li Wang,1,2 Yue-Peng Liu4 1Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China; 2Department of Anesthesiology ...
Liu Y, Yao J, Miao S, Liu S, Wan X, Wang X, Song Z, Zhao Y   +7 more
core  

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Embryonic cerebrospinal fluid pressure in fetal mice in utero: External factors pressurize the intraventricular space

Developmental Dynamics, Volume 255, Issue 6, Page 533-547, June 2026.
Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa, Reina Muramatsu, Takaki Miyata   +2 more
wiley   +1 more source

Sonic Hedgehog signaling in spinal cord injury: mechanisms and therapeutic implications

Frontiers in Molecular Neuroscience
Spinal cord injury is a serious neurological condition that results in severe dysfunction below the level of injury, often leading to long-term disability and impaired quality of life.
Mingjuan Du, Xiaozhen Ji, Weiting Chen
doaj   +1 more source

Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer. [PDF]

Ther Adv Med Oncol, 2020
Noman ASM, Parag RR, Rashid MI, Rahman MZ, Chowdhury AA, Sultana A, Jerin C, Siddiqua A, Rahman L, Shirin A, Nayeem J, Mahmud R, Akther S, Shil RK, Hossain I, Alam S, Chowdhury A, Basher SB, Hasan A, Bithy S, Aklima J, Rahman M, Chowdhury N, Banu T, Karakas B, Yeger H, Farhat WA, Islam SS.   +27 more
europepmc   +1 more source