Results 111 to 120 of about 66,099 (245)

Frequent and specific immunity to the embryonal stem cell–associated antigen SOX2 in patients with monoclonal gammopathy [PDF]

, 2007
Radek Špíšek, Anjli Kukreja, Lin-Chi Chen, Phillip Matthews, Amitabha Mazumder, David H. Vesole, Sundar Jagannath, Henry Zebroski, Andrew J.G. Simpson, Gerd Ritter, Brian G.M. Durie, John Crowley, John D. Shaughnessy, Matthew J. Scanlan, Ali O. Güre, Bart Barlogie, Madhav V. Dhodapkar   +16 more
openalex   +1 more source

CRISPR Screening Reveals a Novel Role for FOXH1 in Regulating Pluripotency of Porcine Embryonic Stem Cells

Advanced Science, EarlyView.
This study performs dual CRISPR screens in pEPSCs. Fitness screening identifies essential genes for viability, while FACS‐based screening uncovers core pluripotency factors. It highlights FOXH1 as a key regulator that maintains the stem cell state through a dual‐action mechanism: preserving pluripotency by enhancing chromatin accessibility and ...
Peng Su, Linhui Wu, Delong Li, Wenting Song, Dagang Tao, Liang Liu, Qi Wang, Manxin Gao, Tian Xu, Xin Liu, Shengsong Xie, Xia Zhang, Jilong Zhou, Yi‐Liang Miao   +13 more
wiley   +1 more source

Expression of LHX3 and SOX2 during mouse inner ear development [PDF]

, 2007
Clifford R. Hume, Debbie Bratt, Elizabeth C. Oesterle   +2 more
openalex   +1 more source

Bioactive siRNA‐Based Liposomes Promoted Tendon‐Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248+ TSPCs

Advanced Science, EarlyView.
In this study, it is found that osteoporosis leads to disturbances in the Extracellular Matrix (ECM)of tendons and thus causes a decrease in TSPC stemness, resulting in a rotator cuff that is easily damaged and prone to retearing after repair. Targeted intervention with si‐CD248‐loaded liposomes can restore TSPC stemness, promote tendon‐bone healing ...
Yinhua Qian, Jinguo Zhu, Yanwei He, Haocheng Qin, Pingkang Qian, Bingfeng Sun, Haoqiang Huang, Chen Kuang, Quan Yang, Yuxi Ou, Rong Sun, Feng Xu, Xianwen Wang, Zhiwen Luo, Qing Wang   +14 more
wiley   +1 more source

Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes [PDF]

, 2007
Bauke de Boer, Janel L. Kopp, Sunil K. Mallanna, Michelle Desler, Harini Chakravarthy, Phillip J. Wilder, Cory T. Bernadt, Angie Rizzino   +7 more
openalex   +1 more source

Elezanumab Accelerates Post‐Injury Regeneration of Olfactory Sensory Neurons in a Methimazole‐Induced Mouse Model

International Forum of Allergy &Rhinology, EarlyView.
Key Points Elezanumab accelerates olfactory sensory neuron regeneration in a methimazole‐induced mouse model. Repulsive guidance molecule A blockade increases GAP43+ and OMP+ cells dorsally while sparing basal cells. This approach offers a novel therapy for sensorineural olfactory disorder.
Eri Mori, Rumi Ueha, Hirotaka Tanaka, Hironobu Nishijima, Masayoshi Kobayashi, Nobuyoshi Otori, Kenji Kondo   +6 more
wiley   +1 more source

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration. [PDF]

Int J Cancer
What's new? SOX2 is one of the key developmental genes with a reported altered expression in many tumors. The mechanisms underlying SOX2 regulation in cancer, however, remain elusive. This study shows that TP53 transcriptionally regulates SOX2 through binding to its promoter and the SRR2 enhancer.
Lado-Fernández P, Vilas JM, Fernandes T, Carneiro C, Da Silva-Álvarez S, Estévez-Souto V, Pedrosa P, González-Barcia M, Abatti LE, Mitchell JA, Rivas C, Moreno-Bueno G, Vidal A, Collado M.   +13 more
europepmc   +2 more sources

Expression of Sox2 in mature and immature teratomas of central nervous system [PDF]

, 2007
Ji Hoon Phi, Sung‐Hye Park, Sun Ha Paek, Seung-Ki Kim, Yun Jin Lee, Chul‐Kee Park, Byung-Kyu Cho, Do‐Hun Lee, Kyu‐Chang Wang   +8 more
openalex   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

Parsing pluripotency: the role of Sox2 [PDF]

, 2007
Natalie DeWitt
openalex   +1 more source