Results 121 to 130 of about 66,099 (245)
Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning
Advanced NanoBiomed Research, EarlyView.Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang +7 more
wiley +1 more source
Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation
Advanced NanoBiomed Research, EarlyView.Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos +2 more
wiley +1 more source
Animal Research and One Health, EarlyView.Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao +11 more
wiley +1 more source
What Epigenetics Teaches Us About Neuron–Glioma Interactions
BioEssays, EarlyView.Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty +2 more
wiley +1 more source
SOX2 interacts with hnRNPK to modulate alternative splicing in mouse embryonic stem cells
Cell & BioscienceBackground SOX2 is a determinant transcription factor that governs the balance between stemness and differentiation by influencing transcription and splicing programs. The role of SOX2 is intricately shaped by its interactions with specific partners.
Yanlan Huang +7 more
doaj +1 more source
Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data [PDF]
, 2008 Alexei A. Sharov +8 more
openalex +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Single‐cell isolation is an essential step in many biomedical workflows, including genetic analyses and drug‐based assays. It is commonly attempted through limiting dilution into microtiter wells. However, dark optical edge effects at the well periphery make it difficult to confirm which wells contain just one cell.
Joseph A. E. Morgan +3 more
wiley +1 more source
BMEMat, EarlyView.Aminated graphene (G‐NH2) niche matrix plays a pivotal role in precisely manipulating cardiac differentiation and maturation of hiPSCs. The molecular mechanism underlying cardiomyocyte maturation is closely linked to the PDGF‐β signaling pathway. Cardiomyocytes derived from the G‐NH2 matrix exhibit enhanced activity and functionality in vivo.
Yin Xu +6 more
wiley +1 more source
Klf4 Cooperates with Oct3/4 and Sox2 To Activate the Lefty1 Core Promoter in Embryonic Stem Cells
, 2006 Yuhki Nakatake +10 more
openalex +1 more source