Results 151 to 160 of about 66,099 (245)

Moderate Laryngeal Dysplasia in the Context of Classification Systems and Clinical Decision Making

The Laryngoscope, EarlyView.
There is still an ongoing debate about the classification of laryngeal dysplasia. In a large retrospective analysis of 392 patients, the progression of dysplasia and the risk of a de novo occurrence of invasive carcinoma were evaluated. Here especially the high rate of occurrence of invasive carcinoma in the group of moderate dysplasia with 44% is of ...
Flurin Mueller‐Diesing, Manuel Stöth, Elena Ludwig, Andreas Rosenwald, Elena Gerhard‐Hartmann, Helena Moratin, Thomas Gehrke, Miguel Goncalves, Matthias Scheich, Stephan Hackenberg, Agmal Scherzad, Till Jasper Meyer   +11 more
wiley   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Maternal Mosaicism Challenges in Non‐Invasive Prenatal Diagnosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To report the incidental detection of maternal somatic mosaicism during the development of exclusion‐based non‐invasive prenatal diagnosis for monogenic disorders (NIPD‐MD) initially indicated for apparently de novo pathogenic or likely pathogenic variants.
Margot Comel, Marina Lamairia, Odile Boute, Camille Cenni, Anne Bergougnoux, Mireille Cossée, Michel Koenig, Luke Mansard, Marie‐Claire Vincent   +8 more
wiley   +1 more source

Conductive Materials and Electrical Stimulation for Auditory Restoration

Sensory Neuroscience, EarlyView.
Applications of electroconductive biomaterials and electrical stimulation in cochlear tissue engineering.(1) Enable auditory neural repair through conductive materials and electrical stimulation, enhancing neuron survival and synaptic plasticity.(2) Integrate optogenetic‐electrical systems and cochlear organoid platforms for frequency‐specific ...
Menghui Liao, Yuyang Qiu, Qian Zhu, Ziyi Wang, Hong Cheng, Bin Zhang, Cheng Cheng, Lei Tian, Yangnan Hu   +8 more
wiley   +1 more source

High‐Yield Convenient Mass Production of High‐Quality Homogenous Human Induced Pluripotent Stem Cell Spheroids under Rho‐Associated Kinase Inhibitor‐Free 3D Culture Enabled by Micropatterning and Cold‐Triggered Chemical‐Free Cell Detachment

Small Science, EarlyView.
Cold‐responsive micropatterned dishes are fabricated by spin‐coating cell culture dishes with a cold‐responsive polymer and microcontact printing cell‐attachment micropatterns on top of the polymer. The micropatterns can be physically detached as a whole by ice‐cold cooling without using any chemical agents, enabling convenient large‐scale production ...
Zhiyuan Wang, Samantha Stewart, Mitsuo Kumagai, Ethan Wang, Wenquan Ou, Yongyu Lu, Taotao Meng, Cancan Xu, Yi Hong, Shenqiang Ren, Xiaoming He   +10 more
wiley   +1 more source

Mass Production of Uniform Embryoid Bodies by Acoustic Standing Waves

Small Methods, EarlyView.
This innovative method for the generation of human induced pluripotent stem cell (hiPSC)‐derived embryoid bodies provides a scalable, flexible and cell‐friendly approach for the mass production of highly uniform cell clusters. It maintains the high cell viability and pluripotent state of hiPSCs while allowing successful differentiation into ...
Johannes Hahn, Ebru Aksoy, Sarkawt Hamad, Christoph Kuckelkorn, Alejandro Gómez Montoya, Mira Ritter, Kurt Pfannkuche, Horst Fischer   +7 more
wiley   +1 more source

Neuroprotective effects of remote limb ischemic preconditioning through enhanced cerebral blood flow via activation of the PI3K/AKT pathway in ischemic stroke

VIEW, EarlyView.
Stroke is a leading cause of death and disability worldwide, often due the inadequate restoration of cerebral blood flow following vascular recanalization. Our study demonstrates that a simple technique called RLIPC (remote limb ischemic preconditioning), which involves briefly restricting blood flow in a limb, protects the brain during a stroke by ...
Chaoran Dou, Diwen Tang, Yulin Yan, Wen Shui, Minzhi Zhou, Bin Chen, Lishuai Feng, Benhao Li, Tao Ying   +8 more
wiley   +1 more source

Generation of Induced Pluripotent Stem Cells from Human Cord Blood Using OCT4 and SOX2

, 2009
Alessandra Giorgetti, Núria Montserrat, Trond Aasen, Federico González, Ignacio Rodríguez-Pizá, Rita Vassena, Ángel Raya, Stéphanie Boué, María J. Barrero, Begoña Aran Corbella, Marta Torrabadella, Anna Veiga, Juan Carlos Izpisúa Belmonte   +12 more
openalex   +1 more source

Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus [PDF]

, 2010
Dongying Zhang, Suad Efendić, Kerstin Brismar, Harvest F. Gu   +3 more
openalex   +1 more source

PP1γ promotes esophageal squamous cell carcinoma progression through the PP1γ/YAP1/SOX2 axis. [PDF]

Front Oncol
Du J, Liu L, Zheng S, Dai C, Liu J, Zhang W, Pu H, Xue J.   +7 more
europepmc   +1 more source