Results 31 to 40 of about 65,805 (290)
SOX2 in development and cancer biology
Seminars in Cancer Biology, 2020 The transcription factor SOX2 is essential for embryonic development and plays a crucial role in maintaining the stemness of embryonic cells and various adult stem cell populations. On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been shown that SOX2 positively affects cancer cell traits ...
Jochen Utikal +6 more
openaire +3 more sources
Zhongliu Fangzhi Yanjiu, 2020 Objective To explore the effects of Timosaponin (TMS) on lung cancer and cancer stem cell (CSC) and its underlying mechanism. Methods MTS, Hoechst 33342 staining, flow cytometry, cell migration and plate cloning experiments were used to detect the effect
CAO Song +7 more
doaj +1 more source
Neural Development, 2021 Background The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to spinal cord regeneration ...
Gabriela Edwards-Faret +5 more
doaj +1 more source
Cells, 2020 Ameloblastomas are locally invasive and aggressive odontogenic tumors treated via surgical resection, which results in facial deformity and significant morbidity.
Pierfrancesco Pagella +3 more
doaj +1 more source
Sox2 in the differentiation of cochlear progenitor cells [PDF]
Scientific Reports, 2016 AbstractHMG domain transcription factor, Sox2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but this has been ascribed to expansion of the progenitors that become hair cells. Here, we show that Sox2 activated Atoh1, a transcription factor important for hair cell differentiation, through an interaction ...
Albert S.B. Edge +4 more
openaire +4 more sources
SOX2 as a New Regulator of HPV16 Transcription [PDF]
Viruses, 2017 Persistent infections with high-risk human papillomavirus (HPV) constitute the main risk factor for cervical cancer development. HPV16 is the most frequent type associated to squamous cell carcinomas (SCC), followed by HPV18. The long control region (LCR) in the HPV genome contains the replication origin and sequences recognized by cellular ...
Imelda Martínez-Ramírez +10 more
openaire +4 more sources
Sox2 modulation increases naïve pluripotency plasticity [PDF]
iScience, 2020 AbstractInduced pluripotency provides a tool to explore the molecular mechanisms underlying the establishment, maintenance and differentiation of naïve pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-low).
Hannah T. Stuart +12 more
openaire +6 more sources
A Role for Sox2 in the Adult Cerebellum
Journal of Stem Cell Research & Therapy, 2018 The cerebellum, a derivative of the hindbrain, plays a crucial role in balance and posture as well as in higher cognitive and locomotive processes. Cerebellar development is initiated during the segmental phase of hindbrain formation. Here, we describe the phenotype, of a single surviving adult conditional mouse mutant mouse, in which Sox2 function is ...
Eumorphia Remboutsika +6 more
openaire +3 more sources
Radiology and Oncology, 2016 The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung ...
Sodja Eva +5 more
doaj +1 more source
Uncovering the Role of Sox2 in Oligodendroglia [PDF]
The Journal of Neuroscience, 2018 In the CNS, oligodendrocytes are responsible for the formation of myelin. To build these insulating sheaths surrounding axons, cells of the oligodendrocyte lineage must go through an intricate and temporally matched sequence of proliferation, migration, differentiation, and myelination ...
openaire +3 more sources