Results 31 to 40 of about 70,586 (295)
Sox2 Uses Multiple Domains to Associate with Proteins Present in Sox2-Protein Complexes
PLoS ONE, 2010 Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC). These master regulators associate with co-activators and co-repressors to precisely control their gene targets. Recent studies using proteomic analysis have identified a large, diverse group of co-
Jesse L Cox +3 more
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Sox2 goes beyond stem cell biology [PDF]
Cell Cycle, 2016 Diversity in neuronal types provides us with the ability to form complex thoughts and functions.
Amel, Alqadah +2 more
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Cellular Reprogramming Employing Recombinant Sox2 Protein [PDF]
Stem Cells International, 2012 Induced pluripotent stem (iPS) cells represent an attractive option for the derivation of patient-specific pluripotent cells for cell replacement therapies as well as disease modeling. To become clinically meaningful, safe iPS cells need to be generated exhibiting no permanent genetic modifications that are caused by viral integrations of the ...
Marc Thier +3 more
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SOX2 contributes to melanoma cell invasion [PDF]
Laboratory Investigation, 2012 The mechanisms of melanoma invasion are poorly understood despite extensive inquiry. SRY (sex determining region Y)-box 2 (SOX2) is an embryonic stem cell transcription factor that has recently been discovered to be expressed in human melanoma where it is associated with dermal invasion and primary tumor thickness.
Sasha D, Girouard +8 more
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Cells, 2020 Ameloblastomas are locally invasive and aggressive odontogenic tumors treated via surgical resection, which results in facial deformity and significant morbidity.
Pierfrancesco Pagella +3 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2020 Objective To explore the effects of Timosaponin (TMS) on lung cancer and cancer stem cell (CSC) and its underlying mechanism. Methods MTS, Hoechst 33342 staining, flow cytometry, cell migration and plate cloning experiments were used to detect the effect
CAO Song +7 more
doaj +1 more source
Sox2 Suppresses Gastric Tumorigenesis in Mice [PDF]
Cell Reports, 2016 Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach homeostasis and disease. By using ChIP-seq analysis, we have found that the majority of Sox2 targets in gastric epithelial cells are tissue specific and related to functions such as ...
Sarkar, Abby +16 more
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Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration
eLife, 2020 The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout lifetime. To mimic the HC damage in mammals,
Zhian Ye +8 more
doaj +1 more source
Molecular Oncology, 2021 The involvement of LncRNA SOX2‐overlapping transcript (SOX2‐OT), SOX2, and GLI‐1 transcription factors in cancer has been well documented. Nonetheless, it is still unknown whether co‐expressed SOX2‐OT/SOX2 or SOX2‐OT/SOX2/GLI‐1 axes are epigenetically ...
Abril Marcela Herrera‐Solorio +12 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source