Results 21 to 30 of about 21,277,776 (188)

The combination of soluble forms of PD-1 and PD-L1 as a predictive marker of PD-1 blockade in patients with advanced cancers: a multicenter retrospective study

Frontiers in Immunology, 2023
IntroductionThe clinical relevance of soluble forms of programmed cell death-1 (sPD-1) and programmed cell death-ligand 1 (sPD-L1) remains unclear. We here investigated the relation between the efficacy of PD-1 blockade and pretreatment plasma levels of ...
Takashi Kurosaki, Kenji Chamoto, Kenji Chamoto, Shinichiro Suzuki, Hiroaki Kanemura, Seiichiro Mitani, Kaoru Tanaka, Hisato Kawakami, Yo Kishimoto, Yasuharu Haku, Katsuhiro Ito, Toshiyuki Sato, Chihiro Suminaka, Mami Yamaki, Yasutaka Chiba, Tomonori Yaguchi, Tomonori Yaguchi, Koichi Omori, Takashi Kobayashi, Kazuhiko Nakagawa, Tasuku Honjo, Hidetoshi Hayashi   +21 more
doaj   +1 more source

Serum programmed cell death proteins in amyotrophic lateral sclerosis

Brain, Behavior, & Immunity - Health, 2021
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscular disorder. Activation of programmed cell death-1 (PD-1), and its ligands, programmed cell death-ligand 1 and 2 (PD-L1/L2), leads to immune suppression ...
David R. Beers, Weihua Zhao, Jason R. Thonhoff, Alireza Faridar, Aaron D. Thome, Shixiang Wen, Jinghong Wang, Stanley H. Appel   +7 more
doaj   +1 more source

The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer

Turkish Journal of Biochemistry, 2021
Abstract Objectives Immunoregulatory GITR, OX40L and PD-1 molecules play an active role in the regulation of tumor microenvironment and have been shown in many cancer types. However, there are limited studies of these molecules in terms of gastric cancer. In our study, we aimed to determine the
Cem Horozoglu, Dilara Sonmez, Ozlem Kucukhuseyin, Seyda Demirkol, Mehmet Tolgahan Hakan, Soykan Arikan, İlhan Yaylim   +6 more
openaire   +1 more source

Serum soluble PD‐1 plays a role in predicting infection complications in patients with acute pancreatitis

Immunity, Inflammation and Disease, 2021
Background Most of acute pancreatitis (AP) are mild and self‐limiting, however, 15%–20% of patients develop severe acute pancreatitis (SAP) or moderately acute pancreatitis (MSAP) with local or systemic complications. Infection complications (ICs) result
Xingxing Yu, Yu Pan, Qinglin Fei, Xianchao Lin, Zhijiang Chen, Heguang Huang   +5 more
doaj   +1 more source

SPD-1 and KLP-19 localize on the meiotic spindle independently of BMK-1 and each other.

, 2023
(A) Quantifications of SPD-1::GFP signal intensity on the spindle relative to mCherry::H2B intensity, at anaphase B onset and anaphase B on control, bmk-1(ok391) and klp-19(RNAi);bmk-1(ok391) spindles.
Wenzhe Li (815057), Dhanya Cheerambathur (353823), Helena A. Crellin (17706085), Francis J. McNally (14002769)   +3 more
core   +1 more source

Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells

Frontiers in Immunology, 2023
NK cells represent important effectors that play a major role in innate defences against pathogens and display potent cytolytic activity against tumor cells. An array of surface receptors finely regulate their function and inhibitory checkpoints, such as
Francesca Romana Mariotti, Tiziano Ingegnere, Nadine Landolina, Nadine Landolina, Paola Vacca, Enrico Munari, Lorenzo Moretta   +6 more
doaj   +1 more source

SPD-1 Is Required for the Formation of the Spindle Midzone but Is Not Essential for the Completion of Cytokinesis in C. elegans Embryos [PDF]

Current Biology, 2004
The process of cytokinesis can be divided into two stages: the assembly and constriction of an actomyosin ring giving rise to a narrow intracellular canal and the final breaking and resealing of this canal. Mutations in several genes of Caenorhabditis elegans disrupt the spindle midzone (anti-parallel microtubules and associated proteins that form ...
Verbrugghe, Koen J.C., White, John G.
openaire   +3 more sources

Association between response to anti-PD-1 treatment and blood soluble PD-L1 and IL-8 changes in patients with NSCLC

Discover Oncology, 2023
In this study, we explored the dynamic changes in blood sPD-L1 and its clinical value during anti-PD-1 immunotherapy in non-small cell lung cancer (NSCLC) patients.
Ling Yi, Xiaojue Wang, Siyun Fu, Zhuohong Yan, Tianyu Ma, Siqi Li, Panjian Wei, Hongtao Zhang, Jinghui Wang   +8 more
doaj   +1 more source

Soluble forms of immune checkpoint receptor PD-1 and its ligand PD-L1 in plasma of patients with ovarian neoplasms

Alʹmanah Kliničeskoj Mediciny, 2018
Background: Ovarian cancer is one of the most common oncologic diseases holding the frst place in mortality related to neoplasms of female genitalia.
E. S. Gershtein, D. O. Utkin, I. O. Goryacheva, M. M. Khulamkhanova, N. A. Petrikova, I. I. Vinogradov, A. A. Alferov, I. S. Stilidi, N. E. Kushlinskii   +8 more
doaj   +1 more source

Increased Plasma Soluble PD-1 Concentration Correlates with Disease Progression in Patients with Cancer Treated with Anti-PD-1 Antibodies

Biomedicines, 2021
Immune checkpoint inhibitors (ICIs) confer remarkable therapeutic benefits to patients with various cancers. However, many patients are non-responders or develop resistance following an initial response to ICIs.
Ryotaro Ohkuma, Katsuaki Ieguchi, Makoto Watanabe, Daisuke Takayanagi, Tsubasa Goshima, Rie Onoue, Kazuyuki Hamada, Yutaro Kubota, Atsushi Horiike, Tomoyuki Ishiguro, Yuya Hirasawa, Hirotsugu Ariizumi, Junji Tsurutani, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada   +18 more
doaj   +1 more source