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Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy? [PDF]
International Journal of Molecular Sciences, 2021 Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional analgesic treatments, specialized pro-resolving lipid ...
Alexander Manzano +2 more
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Delivery systems for incorporation of specialized pro-resolving mediators
Journal of Pharmaceutical SciencesThe acute process of inflammation triggers the production of specialized pro-resolving mediators (SPMs), which is a resolutive class of oxylipins that actively orchestrate the resolution phase of the inflammatory process and contribute to regaining tissue homeostasis.
Ellen Nobrega de Azevedo +6 more
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Specialized pro-resolving mediators in diabetes: novel therapeutic strategies
Clinical Science, 2019Abstract Diabetes mellitus (DM) is an important metabolic disorder characterized by persistent hyperglycemia resulting from inadequate production and secretion of insulin, impaired insulin action, or a combination of both. Genetic disorders and insulin receptor disorders, environmental factors, lifestyle choices and toxins are key ...
Eoin P. Brennan +4 more
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Role of the Specialized Pro-resolving Mediator Resolvin D1 in Hashimotoʼs Thyroiditis
Experimental and Clinical Endocrinology & Diabetes, 2021Abstract Objective Resolvins are produced by the catabolism of polyunsaturated fatty acids (PUFAs) and play vital roles in inflammation resolution. Resolvins have been associated with autoimmune disorders. This study aimed to measure the level of Resolvin D1 (RVD1) in the serum of Hashimoto's thyroiditis (HT) patients and healthy controls (HCs) and to ...
Jing, Song +4 more
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Developments of specialized pro-resolving mediators in periodontitis.
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2021Resolution of inflammation plays an important part in maintaining homeostasis. It is an actively programmed progress involving multiple immune cells and mediators. Specialized pro-resolving mediators (SPMs) derived from Ω-3 polyunsaturated fatty acids include resolvins, protectins and maresins, and they exert abilities in the resolution of inflammation,
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The overlooked complexity of Resolution: Specialized pro-resolving mediators in focus
European Journal of PharmacologySpecialized pro-resolving mediators (SPMs) have emerged as the key regulators of inflammation resolution, marking a shift in therapeutic paradigms. Although numerous studies highlight their therapeutic potential, several questions remain unanswered, especially concerning the human biological mechanism.
Akanksha Jha, Hemant Kumar
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Specialized pro‐resolving lipid mediators in experimental periodontitis: A systematic review
Oral Diseases, 2018AbstractRecently, several studies demonstrated the potential of using specialized pro‐resolving lipid mediators (SPMs), as a novel approach, in treating periodontitis in pre‐clinical models. This review aimed to systematically evaluate the biological actions of SPMs on periodontal tissues in animals with experimentally induced periodontitis.
Marcela M. Osorio Parra +2 more
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Effect of specialized pro-resolving mediators on knee joint inflammation
The KneeChronic inflammation following knee injuries often results in persistent knee pain and post-traumatic osteoarthritis (PTOA). Understanding the inflammatory processes that follow a joint injury is crucial to effectively mitigate PTOA progression. While inflammation is an integral part of any healing response, unresolved, long-lasting inflammation can be
Chilan Bou Ghosson, Leite +4 more
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Exploring the unique role of specialized pro-resolving mediators in cancer therapeutics
Prostaglandins & Other Lipid MediatorsUnresolved chronic inflammation, a hallmark of cancer, promotes tumor growth and metastasis in various cancer types. In contrast to blocking inflammation, stimulation of resolution of inflammation is an entirely novel approach to "resolve" inflammation.
Katherine M, Quinlivan +6 more
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