Results 51 to 60 of about 12,113 (180)

Mammalian sperm capacitation: In vivo and in vitro juxtaposition

Veterinary Integrative Sciences, 2022
The development of assisted reproductive technologies (ART) in mammalian species such as in vitro embryo production (IVEP) has the potential to provide great benefits for significant population increase, improve genetic performance and ...
Haris Setiawan, Phongsakorn Chuammitri, Korawan Sringarm, Montira Intanon, Anucha Sathanawongs   +4 more
doaj   +1 more source

Low‐Level Human Epididymis Protein 4 in Seminal Plasma Is an Independent Risk Factor for Poor Semen Liquefaction: A Case Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
Our work identifies a novel and significant association between low seminal levels of Human Epididymis Protein 4 (HE4) and the clinical condition of poor semen liquefaction, a common cause of male infertility. The findings are statistically robust, clinically relevant, and provide a foundational basis for future research into the mechanism by which HE4
Feifei Wang, Jiangnan Wu, Shijie Gao, Zhuohan Zheng, Zhiheng Wang, Jing Gao   +5 more
wiley   +1 more source

Mitochondrial Activation and Reactive Oxygen-Species Overproduction during Sperm Capacitation are Independent of Glucose Stimuli

Antioxidants, 2020
Spermatozoa capacitation is a complex process that requires specific ionic and energetic conditions to support biochemical alterations leading to motility hyperactivation. However, human sperm capacitation is still poorly understood.
David F. Carrageta, Bárbara Guerra-Carvalho, Mário Sousa, Alberto Barros, Pedro F. Oliveira, Mariana P. Monteiro, Marco G. Alves   +6 more
doaj   +1 more source

Toward a Politics of (In)Fertility: Reproductive Debility in Africa

American Anthropologist, EarlyView.
ABSTRACT Sub‐Saharan Africa has some of the highest estimated rates of infertility or involuntary childlessness in the world, leading epidemiologists to refer to parts of the region as the “infertility belt.” The medicalization of infertility and the situating of assisted reproductive technologies (ARTs) as the treatment for infertility have siphoned ...
Tessa Moll
wiley   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, EarlyView.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Zinc ion flux during mammalian sperm capacitation

Nature Communications, 2018
During sperm capacitation physiological changes occur that are required for fertilization. Here, the authors describe four sperm zinc signatures during invitro capacitation that are indicative of sperm quality and capacity to fertilize.
Karl Kerns, Michal Zigo, Erma Z. Drobnis, Miriam Sutovsky, Peter Sutovsky   +4 more
doaj   +1 more source

Impact of Sorting and Catch Media on Porcine Sperm Motility, Capacitation, and Viability

Andrology, EarlyView.
ABSTRACT Background Fluorescence‐activated cell sorting (FACS) has emerged as a powerful tool for selecting spermatozoa of a desired population of fluorescent biomarkers, offering potential applications in reproductive biology and agriculture. However, concerns remain regarding sorting‐induced physiological alterations that could compromise spermatozoa
Tyler Weide, Juan Steibel, Karl Kerns
wiley   +1 more source

Sperm Adhesion Molecule 1 (SPAM1) Distribution in Selected Human Sperm by Hyaluronic Acid Test

Biomedicines, 2022
The failures of binding to the oocyte zona pellucida are commonly attributed to defects in the sperm recognition, adhesion, and fusion molecules. SPAM1 (sperm adhesion molecule 1) is a hyaluronidase implicated in the dispersion of the cumulus-oocyte ...
María José Gómez-Torres, Paula Sáez-Espinosa, Paula Manzano-Santiago, Laura Robles-Gómez, Natalia Huerta-Retamal, Jon Aizpurua   +5 more
doaj   +1 more source

Microfluidic Intracytoplasmic Sperm Injection (MICSI): A Novel Platform for Sperm Isolation, Selection, and Injection Into Oocytes

Andrology, EarlyView.
ABSTRACT Background Infertility is a pressing global health concern, affecting one in six couples worldwide. The failure rate for assisted reproductive technologies (ART) cycles remains at approximately 78%, with limited improvements often attributed to a lack of technological innovation.
Mehran Dabiri, Dale Mark Goss, Steven Alexander Vasilescu, Majid Ebrahimi Warkiani   +3 more
wiley   +1 more source