Results 51 to 60 of about 21,661 (226)

Capacitation-Induced Mitochondrial Activity Is Required for Sperm Fertilizing Ability in Mice by Modulating Hyperactivation

Frontiers in Cell and Developmental Biology, 2021
To become fully competent to fertilize an egg, mammalian sperm undergo a series of functional changes within the female tract, known as capacitation, that require an adequate supply and management of energy.
María Milagros Giaccagli, Matías Daniel Gómez-Elías, Jael Dafne Herzfeld, Clara Isabel Marín-Briggiler, Patricia Sara Cuasnicú, Débora Juana Cohen, Vanina Gabriela Da Ros   +6 more
doaj   +1 more source

KCNQ1 Potassium Channel Expressed in Human Sperm Is Involved in Sperm Motility, Acrosome Reaction, Protein Tyrosine Phosphorylation, and Ion Homeostasis During Capacitation

Frontiers in Physiology, 2021
Potassium channels are involved in membrane hyperpolarization and ion homeostasis regulation during human sperm capacitation. However, the types of potassium channels in human sperm remain controversial.
Tian Gao, Kun Li, Kun Li, Fei Liang, Fei Liang, Jianmin Yu, Jianmin Yu, Ajuan Liu, Ya Ni, Ya Ni, Peibei Sun, Peibei Sun   +11 more
doaj   +1 more source

Capacitation induces changes in metabolic pathways supporting motility of epididymal and ejaculated sperm

Frontiers in Cell and Developmental Biology, 2023
Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted from ...
Melanie Balbach, Lubna Ghanem, Sara Violante, Aye Kyaw, Ana Romarowski, Justin R. Cross, Pablo E. Visconti, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Structural prediction and in silico physicochemical characterization for mouse caltrin I and bovine caltrin proteins [PDF]

, 2016
It is known that caltrin (calcium transport inhibitor) protein binds to sperm cells during ejaculation and inhibits extracellular Ca2+ uptake. Although the sequence and some biological features of mouse caltrin I and bovine caltrin are known, their ...
Coronel, Carlos Enrique, Grasso, Ernesto Javier, Sottile, Adolfo Emiliano   +2 more
core   +2 more sources

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, EarlyView.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Determination of a Robust Assay for Human Sperm Membrane Potential Analysis

Frontiers in Cell and Developmental Biology, 2019
Mammalian sperm must undergo a complex process called capacitation in order to fertilize the egg. During this process, hyperpolarization of the sperm plasma membrane has been mostly studied in mouse, and associated to its importance in the preparation to
Carolina Baro Graf, Carolina Baro Graf, Carla Ritagliati, Cintia Stival, Paula A. Balestrini, Mariano G. Buffone, Darío Krapf, Darío Krapf   +7 more
doaj   +1 more source

Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation [PDF]

, 2019
Fibronectin (Fn) enhances human sperm capacitation via the cAMP/PKA pathway, and the endocannabinoid system participates in this process. Moreover, Fn has been linked to endocannabinoid system components in different cellular models, even though no ...
Díaz, Emilce Silvina, Kong, Milene, Martínez León, Eduardo Antonio, Morales, Patricio, Osycka Salut, Claudia Elena, Perez Martinez, Silvina Laura, Signorelli, Janetti   +6 more
core   +1 more source

Sperm Capacitation and Fertilization in Mammals [PDF]

Biology of Reproduction, 1970
PIP: Current evidence and speculations concerning the nature of sperm capacitation in mammals are reviewed and critically assessed. Capacitation, a subtle functional change which must occur at least in some mammals before fertilization can take place, occurs in sperm as a result of exposure to secretions of the female tract.
openaire   +3 more sources

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Heterogeneity in Fluorescence-Stained Sperm Membrane Patterns and Their Dynamic Changes Towards Fertilization in Mice

Frontiers in Bioscience-Landmark
Background: Sperm represent a heterogeneous population crucial for male reproductive success. Additionally, sperm undergo dynamic changes during maturation and capacitation.
Momoka Hirai, Satoshi Kishigami
doaj   +1 more source