Results 41 to 50 of about 218,627 (165)
Dissociation between AKAP3 and PKARII promotes AKAP3 degradation in sperm capacitation. [PDF]
PLoS ONE, 2013 Ejaculated spermatozoa must undergo a series of biochemical modifications called capacitation, prior to fertilization. Protein-kinase A (PKA) mediates sperm capacitation, although its regulation is not fully understood.
Pnina Hillman +3 more
doaj +1 more source
Boar semen improvement through sperm capacitation management, with emphasis on zinc ion homeostasis.
Theriogenology, 2019 Critical to fertilization success, sperm capacitation within the female oviductal sperm reservoir endows mammalian spermatozoa with hyperactivated motility and capacity to fertilize. An elaborate cascade of signaling events during capacitation guides the
P. Sutovsky +3 more
semanticscholar +1 more source
Compartmentalization of the proteasome-interacting proteins during sperm capacitation
Scientific Reports, 2019 Ubiquitination is a stable, reversible posttranslational modification of target proteins by covalent ligation of the small chaperone protein ubiquitin.
M. Zigo +4 more
semanticscholar +1 more source
Effect of estrogens on boar sperm capacitation
Reproductive Biology and Endocrinology, 2010 Background Mammalian sperm must undergo a series of controlled molecular processes in the female reproductive tract called capacitation before they are capable of penetrating and fertilizing the egg.
Ded Lukas +4 more
doaj +1 more source
Development of a biomolecular approach to identify sperm functions and fertility using sperm RNAs
Frontiers in Cell and Developmental Biology, 2023 Infertility affects a significant percentage of couples worldwide, and male factors contribute significantly to this problem. Traditional assessments of male fertility rely primarily on parameters such as sperm motility, morphology, viability, and ...
Won-Ki Pang +2 more
doaj +1 more source
Molecular Basis of Human Sperm Capacitation
Front. Cell Dev. Biol., 2018 In the early 1950s, Austin and Chang independently described the changes that are required for the sperm to fertilize oocytes in vivo. These changes were originally grouped under name of “capacitation” and were the first step in the development of in ...
L. C. P. Puga Molina +5 more
semanticscholar +1 more source
Molecular human reproduction, 2019 One of the first events of mammalian sperm capacitation is the activation of the soluble adenyl cyclase / cAMP / protein kinase A (SACY/cAMP/PKA) pathway. Here, we evaluated whether the increase in PKA activity at the onset of human sperm capacitation is
H. Zapata-Carmona +7 more
semanticscholar +1 more source
Frontiers in Physiology, 2021 Potassium channels are involved in membrane hyperpolarization and ion homeostasis regulation during human sperm capacitation. However, the types of potassium channels in human sperm remain controversial.
Tian Gao +11 more
doaj +1 more source
PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
Advanced Science, EarlyView.PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao +7 more
wiley +1 more source
Determination of a Robust Assay for Human Sperm Membrane Potential Analysis
Frontiers in Cell and Developmental Biology, 2019 Mammalian sperm must undergo a complex process called capacitation in order to fertilize the egg. During this process, hyperpolarization of the sperm plasma membrane has been mostly studied in mouse, and associated to its importance in the preparation to
Carolina Baro Graf +7 more
doaj +1 more source