Results 41 to 50 of about 12,113 (180)

Capacitation induces changes in metabolic pathways supporting motility of epididymal and ejaculated sperm

Frontiers in Cell and Developmental Biology, 2023
Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted from ...
Melanie Balbach, Lubna Ghanem, Sara Violante, Aye Kyaw, Ana Romarowski, Justin R. Cross, Pablo E. Visconti, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Capacitation-Induced Mitochondrial Activity Is Required for Sperm Fertilizing Ability in Mice by Modulating Hyperactivation

Frontiers in Cell and Developmental Biology, 2021
To become fully competent to fertilize an egg, mammalian sperm undergo a series of functional changes within the female tract, known as capacitation, that require an adequate supply and management of energy.
María Milagros Giaccagli, Matías Daniel Gómez-Elías, Jael Dafne Herzfeld, Clara Isabel Marín-Briggiler, Patricia Sara Cuasnicú, Débora Juana Cohen, Vanina Gabriela Da Ros   +6 more
doaj   +1 more source

Protective Effects of Fenugreek and Stevia Extracts on Dexamethasone‐Induced Testicular Damage in a Rat Model

Food Safety and Health, EarlyView.
Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad, Medhat Ibrahim A. Omar, Mohammed I. Elkhateeb, Ahmed A. Zaky   +3 more
wiley   +1 more source

Determination of a Robust Assay for Human Sperm Membrane Potential Analysis

Frontiers in Cell and Developmental Biology, 2019
Mammalian sperm must undergo a complex process called capacitation in order to fertilize the egg. During this process, hyperpolarization of the sperm plasma membrane has been mostly studied in mouse, and associated to its importance in the preparation to
Carolina Baro Graf, Carolina Baro Graf, Carla Ritagliati, Cintia Stival, Paula A. Balestrini, Mariano G. Buffone, Darío Krapf, Darío Krapf   +7 more
doaj   +1 more source

EFFECT OF DIFFERENT L-ARGININE CONCENTRATIONS ON IN VITRO BUFFALO SEMEN FERTILIZING POTENTIALS [PDF]

Assiut Veterinary Medical Journal, 2016
Sperm capacitation and acrosome reaction are essential for fertilization. L-Arginine plays an important role in the physiology of spermatozoa and has been shown to enhance their metabolism and maintain their motility.
MONTASER, A., BADR, M.R.
doaj   +1 more source

KCNQ1 Potassium Channel Expressed in Human Sperm Is Involved in Sperm Motility, Acrosome Reaction, Protein Tyrosine Phosphorylation, and Ion Homeostasis During Capacitation

Frontiers in Physiology, 2021
Potassium channels are involved in membrane hyperpolarization and ion homeostasis regulation during human sperm capacitation. However, the types of potassium channels in human sperm remain controversial.
Tian Gao, Kun Li, Kun Li, Fei Liang, Fei Liang, Jianmin Yu, Jianmin Yu, Ajuan Liu, Ya Ni, Ya Ni, Peibei Sun, Peibei Sun   +11 more
doaj   +1 more source

Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations

Journal of Applied Toxicology, EarlyView.
ABSTRACT Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress–related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX‐induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX‐associated redox
Caner Öztürk, Neşe Hayat Aksoy, Erkan Özkan, Ayşe Ikinci Keleş, Ahmet Karabulut   +4 more
wiley   +1 more source

Heterogeneity in Fluorescence-Stained Sperm Membrane Patterns and Their Dynamic Changes Towards Fertilization in Mice

Frontiers in Bioscience-Landmark
Background: Sperm represent a heterogeneous population crucial for male reproductive success. Additionally, sperm undergo dynamic changes during maturation and capacitation.
Momoka Hirai, Satoshi Kishigami
doaj   +1 more source

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

Sperm Capacitation and Fertilization in Mammals [PDF]

Biology of Reproduction, 1970
PIP: Current evidence and speculations concerning the nature of sperm capacitation in mammals are reviewed and critically assessed. Capacitation, a subtle functional change which must occur at least in some mammals before fertilization can take place, occurs in sperm as a result of exposure to secretions of the female tract.
openaire   +3 more sources