Results 81 to 90 of about 218,627 (165)

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Essential role of CFTR in PKA-dependent phosphorylation, alkalinization and hyperpolarization during human sperm capacitation

Journal of Cellular Physiology, 2016
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
L. C. P. Puga Molina, Nicolás A. Pinto, Paulina Torres Rodríguez, Ana Romarowski, Alberto Vicens Sanchez, P. Visconti, A. Darszon, C. Treviño, Mariano G. Buffone   +8 more
semanticscholar   +1 more source

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

Environmental Toxicology, Volume 41, Issue 7, Page 379-394, July 2026.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese, Mariachiara Galati, Tiziana Cappello, Maria Maisano, Gennaro Lettieri, Carmela Marinaro, Marina Piscopo, Gianluca Fasciolo, Carlos Gravato, Gaetana Napolitano, Giulia Paolella, Annamaria Locascio, Rosaria Scudiero, Luigi Rosati   +13 more
wiley   +1 more source

Cryptorchidism: Novel genetic insights into CCDC149 mutations

Andrology, Volume 14, Issue 5, Page 1155-1163, July 2026.
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li   +8 more
wiley   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, Volume 14, Issue 5, Page 1240-1248, July 2026.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

Bioprospecting snakehead fish protein concentrate (SFC) as a non non-serumserum-based albumin source for promoting capacitation in bovine sperm

Journal of the Indonesian Tropical Animal Agriculture
Capacitation is a prerequisite for successful fertilization with albumin as an inevitable component among the oviductal fluid's constituents. Under in vitroenvironments, albumin's function is replaced by serum-based products, which carry the issue of ...
H. Setiawan, T. Lertwichaikul, M. Thongkham, P. Chuammitri, K. Sringarm, M. Intanon, A. Sathanawongs   +6 more
doaj   +1 more source

Focal adhesion kinase is required for actin polymerization and remodeling of the cytoskeleton during sperm capacitation

Biology Open, 2016
Several focal adhesion proteins are known to cooperate with integrins to link the extracellular matrix to the actin cytoskeleton; as a result, many intracellular signaling pathways are activated and several focal adhesion complexes are formed.
Ana L. Roa-Espitia, Eva R Hernández-Rendón, Rafael Baltiérrez-Hoyos, R. Muñoz-Gotera, A. Cote-Vélez, I. Jiménez, H. González-Márquez, E. Hernández-González   +7 more
semanticscholar   +1 more source

Pig Seminal Plasma Extracellular Vesicles Enhance Motility During Preservation of Epididymal Spermatozoa but Impair Capacitation and IVF Parameters

Andrology, Volume 14, Issue 5, Page 1249-1260, July 2026.
ABSTRACT Background Extracellular vesicles (EVs) produced by accessory sex glands play a key role in sperm functionality, influencing motility, viability, acrosome integrity, metabolic activity, and capacitation. Most studies on the effects of EVs on spermatozoa have focused on ejaculated spermatozoa, which have already been exposed to their own native
Ana Moya‐Fernández, Santa María Toledo‐Guardiola, Peter Silke, Sergio Navarro‐Serna, Carmen Matás   +4 more
wiley   +1 more source

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Regulation of Sperm Capacitation and the Acrosome Reaction by PIP 2 and Actin Modulation

Asian Journal of Andrology, 2015
Actin polymerization and development of hyperactivated (HA) motility are two processes that take place during sperm capacitation. Actin polymerization occurs during capacitation and prior to the acrosome reaction, fast F-actin breakdown takes place.
Haim Breitbart, Maya Finkelstein
doaj   +1 more source