Results 31 to 40 of about 16,857 (217)

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Генетические факторы нарушения сперматогенеза у мужчин со сниженной репродуктивной функцией

Фактори експериментальної еволюції організмів, 2014
Aims. The correlation of DNA fragmentation level with classic sperm parameters, the male age and the level of immature spermatozoa and sperm aneuploidies was investigated. Methods.
Е. С. Жилкова, А. М. Феськов, И. М. Безпечная, А. М. Федота   +3 more
doaj  

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

SPERM MORPHOLOGICAL ABNORMALITIES AS INDICATORS OF DNA FRAGMENTATION AND FERTILIZATION IN ASSISTED REPRODUCTION

Zdravniški Vestnik, 2018
Background. To determine the relationship between sperm morphological abnormalities, DNA fragmentation and fertilization rate in IVF and ICSI. Methods. Sperm samples from 10 IVF and 20 ICSI cycles were analyzed.
Barbara Dariš, Veljko Vlaisavljević
doaj   +1 more source

Comparison of three sperm selection methods for ICSI-DGC, Cumulus column, and incubation with supernatant product of adipose tissue-derived adult stem cells: An experimental study

International Journal of Reproductive BioMedicine, 2021
Background: The examination of sperm parameters and sperm DNA integrity are necessary for male fertility expression. These parameters can be affected by method of sperm separation.
Zeynab Yazdanpanah, Mitra Heydari Nasrabadi, Zeynab Piravar   +2 more
doaj   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Effect of bacterial infection on sperm quality and DNA fragmentation in subfertile men with Leukocytospermia

BMC Molecular and Cell Biology, 2021
Background Although bacterial infections have been recognized as a possible cause of male infertility, the effect of bacterial infections on sperm quality and sperm DNA fragmentation remains controversial.
Fatemeh Eini, Maryam Azizi Kutenaei, Fayegheh Zareei, Zeinolabedin Sharifian Dastjerdi, Maryam Hosseinzadeh Shirzeyli, Ensieh Salehi   +5 more
doaj   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Effects of sperm preparation techniques on sperm survivability and DNA fragmentation

Journal of International Medical Research, 2022
Objective This study was performed to determine the effect of swim-up (SU) and density gradient centrifugation (DGC) on sperm survival and DNA fragmentation.
Minh Tam Le, Hong Nhan Thi Dang, Trung Van Nguyen, Thai Thanh Thi Nguyen, Quoc Huy Vu Nguyen, Ngoc Thanh Cao   +5 more
doaj   +1 more source