Results 41 to 50 of about 5,422,149 (177)

Genes involved in spermatogonial stem cell self-renewal and differentiation [PDF]

, 2008
Spermatozoa are produced by the process of spermatogenesis. At the base of this process is a pool of spermatogonial stem cells that generate new stem cells as well as committed spermatogonia that will eventually differentiate in spermatozoa.
Genes/proteins responsible for the regulation of proliferation and differentiation of spermatogonial stem cells, van Bragt, M.P.A., Dep Biologie   +2 more
core   +1 more source

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

, 2016
The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly understood.
Wu, Zhaoting, Onder, Tamer, Tintara, Supisara, Xia, Qing, Asara, John M., Ratanasirintrawoot, Sutheera, Collins, James J., Ng, Shyh-Chang, Trapnell, Cole, Sliz, Piotr, Chandrasekaran, Sriram, Cacchiarelli, Davide, Wang, Longfei, Mikkelsen, Tarjei, Daley, George Q., Marto, Jarrod A., Teitell, Michael A., Ficarro, Scott B., Ross, Christian A., Shinoda, Gen, Zhang, Jin, Li, Hu, Xie, Wen, Yu, Chunxiao, Loh, Yuin-Han, Cahan, Patrick, Seligson, Marc   +26 more
core   +1 more source

Defining the spermatogonial stem cell [PDF]

, 2004
Through the use of donor cells from transgenic rats expressing GFP exclusively in the germline, we have defined culture conditions where male germ cells lose (on STO cells) or maintain (on MSC-1 cells) stem cell activity. A cadre of germ cell transcripts
Schultz, Nikolaus, Cronkhite, Jennifer T., Kent Hamra, F., Chapman, Karen M., Hammer, Robert E., Garbers, David L., Grellhesl, Dana M.   +6 more
core   +1 more source

Nanotechnology Applied to Stem Cell-Substratum Interactions [PDF]

, 2008
The modulation of biological interaction with artificial surfaces is a vital aspect of biomaterials research. Perhaps the most challenging area is transplantation involving the introduction of stem cells into the body with their ability to ...
Aref, Amirreza
core   +6 more sources

Follicle stimulating hormone increases spermatogonial stem cell colonization during in vitro co - culture [PDF]

Veterinary Research Forum, 2013
The complex process of spermatogenesis is regulated by various factors. Studies onspermatogonial stem cells(SCCs)have provided very important tool to improve herd geneticand different field.
Reza Narenji Sani, Parviz Tajik, Mohammad Hassan Yousefi, Mansoureh Movahedin, Babak Qasemi-Panahi, Shiva Shafiei, Mahmood Ahmadi Hamedani   +6 more
doaj  

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes [PDF]

, 2014
Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to ...
Tang, D, Suzuki, H., Forrest, Alistair R. R., Hasegawa, Y., Suzuki, H, Ovchinnikov, Dmitry A., Hitchens, Kelly J., Takahashi, N., Forrest, A.R.R., Kenna, Tony, Suzuki, Harukazu, Tang, D., Joshi, Anagha, Hayashizaki, Y., Wolvetang, Ernst, Tang, Dave, Suzuki, H., Forrest, Alistair R R, FANTOM Consortium, the FANTOM consortium, Vijayan, Dipti, Wells, Christine A., Hasegawa, Y, Hayashizaki, Yoshihide, Forrest, ARR, Takahashi, Naoko, Briggs, James, Hasegawa, Yuki, Blumenthal, Antje, Tang, D., Hayashizaki, Y, ?, ?, Sajantila, Antti, Hasegawa, Y., Takahashi, N, Takahashi, N., Forrest, A. R., Beckhouse, Anthony G., FANTOM Consortium,, Hayashizaki, Y.   +39 more
core   +1 more source

A pumpless monolayer microfluidic device based on mesenchymal stem cell-conditioned medium promotes neonatal mouse in vitro spermatogenesis

Stem Cell Research & Therapy, 2023
Background Childhood cancer treatment-induced gonadotoxicity causes permanent infertility/sub-infertility in nearly half of males. The current clinical and experimental approaches are limited to cryopreservation of prepubertal testicular strips and in ...
Selin Önen, Ali Can Atik, Merve Gizer, Sevil Köse, Önder Yaman, Haluk Külah, Petek Korkusuz   +6 more
doaj   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source