Results 51 to 60 of about 9,914 (214)

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

A pumpless monolayer microfluidic device based on mesenchymal stem cell-conditioned medium promotes neonatal mouse in vitro spermatogenesis

Stem Cell Research & Therapy, 2023
Background Childhood cancer treatment-induced gonadotoxicity causes permanent infertility/sub-infertility in nearly half of males. The current clinical and experimental approaches are limited to cryopreservation of prepubertal testicular strips and in ...
Selin Önen, Ali Can Atik, Merve Gizer, Sevil Köse, Önder Yaman, Haluk Külah, Petek Korkusuz   +6 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Enrichment and transplantation of spermatogonial stem cells [PDF]

International Journal of Andrology, 2000
Spermatogenesis is a complex, highly organized process originated from stem cell spermatogonia. Because there are very few stem cells and they can only be defined by their function, the identification and isolation of these cells has been very difficult.
T, Shinohara, R L, Brinster
openaire   +2 more sources

Spermatogonial Stem Cell Self - renewal and Differentiation [PDF]

, 2017
Mammalian spermatogenesis is a complicated and precisely controlled process that requires spermatogonial stem cells (SSCs). SSCs maintain the stem cell pool, balance self-renewal–commitment with differentiation, and produce millions of sperm daily.
Qiao-Li Zhang, Xin-Hua Lin, Li-Huan Cao
core   +1 more source

Macrophages Contribute to the Spermatogonial Niche in the Adult Testis

Cell Reports, 2015
The testis produces sperm throughout the male reproductive lifespan by balancing self-renewal and differentiation of spermatogonial stem cells (SSCs).
Tony DeFalco, Sarah J. Potter, Alyna V. Williams, Brittain Waller, Matthew J. Kan, Blanche Capel   +5 more
doaj   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Spermatogonial Stem Cell Culture in Oncofertility

Urologic Clinics of North America, 2020
Infertility caused by chemotherapy or radiation treatments negatively impacts patient-survivor quality of life. The only fertility preservation option available to prepubertal boys who are not making sperm is cryopreservation of testicular tissues that contain spermatogonial stem cells (SSCs) with potential to produce sperm and/or restore fertility ...
Sherin, David, Kyle E, Orwig
openaire   +2 more sources

ERM is required for transcriptional control of the spermatogonial stem cell niche [PDF]

, 2005
Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche
Carnes, K., Zhou, Q., Guang-Quan Zhao, Theresa L. Murphy, Natasza Kurpios, Alec M. Cheng, Murphy, T. L., Hofmann, M. -C., Chandrashekar, V., Lim, H., Cheng, A. M., Marie-Claude Hofmann, Zhao, G. -Q., Kurpios, N., Wenjun Ouyang, Varadaraj Chandrashekar, Rex A. Hess, Grigura, V., Chen, C., Kenneth M. Murphy, Ouyang, W., Murphy, K. M., Qing Zhou, John A. Hassell, Kay Carnes, Arber, S., Chen Chen, Hyunjung Lim, Hassell, J. A., Vadim Grigura, Hess, R. A., Silvia Arber   +31 more
core   +1 more source