Results 71 to 80 of about 5,422,149 (177)

Stem cell and stem cell sources in male genital system

Urology Research and Practice, 2019
Human stem cell research which attracts not only scientists’ but the public’s attention is considered to be able to identify the mechanism of human development, and to change the medical practices.
Gülperi Öktem, Ahmet Barış Altay
doaj   +2 more sources

Aberrant gene expression by Sertoli cells in infertile men with Sertoli cell-only syndrome.

PLoS ONE, 2019
Sertoli cell-only (SCO) syndrome is a severe form of human male infertility seemingly characterized by the lack all spermatogenic cells. However, tubules of some SCO testes contain small patches of active spermatogenesis and thus spermatogonial stem ...
Darius A Paduch, Stephanie Hilz, Andrew Grimson, Peter N Schlegel, Anne E Jedlicka, William W Wright   +5 more
doaj   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Genome editing in mouse spermatogonial stem/progenitor cells using engineered nucleases. [PDF]

PLoS ONE, 2014
Editing the genome to create specific sequence modifications is a powerful way to study gene function and promises future applicability to gene therapy.
Danielle A Fanslow, Stacey E Wirt, Jenny C Barker, Jon P Connelly, Matthew H Porteus, Christina Tenenhaus Dann   +5 more
doaj   +1 more source

A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance

Cell Proliferation, EarlyView.
SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu, Xiya Qiu, Wenying Qu, Yue Ma, Mingyuan Bao, Yuxuan Feng, Xiaochu Wang, Tao Zhou, Bo Zheng, Shunyu Hou, Yu Xia, Qingxia Meng   +11 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Data on in vivo phenotypes of GFRα1-positive spermatogonia stimulated by interstitial GDNF signals in mouse testes

Data in Brief, 2016
This article contains the data related to the research article “in vivo dynamics of GFRα1-positive spermatogonia stimulated by GDNF signals using a bead transplantation assay” (Uchida et al., 2016) [1].
Aya Uchida, Yoshiakira Kanai
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]

, 2014
In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier, Fischer, Bruno,, Sommer, Lukas, Sommer, Lukas,, Draganova, Kalina,, Draganova, Kalina, Fischer, Bruno, Cantu, Claudio, Azim, Kasum,, Butt, Arthur, Raineteau, Olivier,, Butt, Arthur,, Azim, Kasum, Hurtado-Chong, Anahi,, Hurtado-Chong, Anahi, Cantù, Claudio,, Zemke, Martina, Zemke, Martina,   +17 more
core   +1 more source