Results 31 to 40 of about 5,422,149 (177)

The Neonatal and Adult Human Testis Defined at the Single-Cell Level

Cell Reports, 2019
Summary: Spermatogenesis has been intensely studied in rodents but remains poorly understood in humans. Here, we used single-cell RNA sequencing to analyze human testes.
Abhishek Sohni, Kun Tan, Hye-Won Song, Dana Burow, Dirk G. de Rooij, Louise Laurent, Tung-Chin Hsieh, Raja Rabah, Saher Sue Hammoud, Elena Vicini, Miles F. Wilkinson   +10 more
doaj   +1 more source

FOXP4 promotes proliferation of human spermatogonial stem cells

Asian Journal of Andrology, 2023
Continuous self-renewal and differentiation of spermatogonial stem cells (SSCs) is vital for maintenance of adult spermatogenesis. Although several spermatogonial stem cell regulators have been extensively investigated in rodents, regulatory mechanisms ...
Shu-Wei Luo, Le Tang, Dai Zhou, Hao Bo, Li-Qing Fan   +4 more
doaj   +1 more source

E-Cadherin regulates neural stem cell self-renewal

, 2009
E-Cadherin, a cell adhesion protein, has been shown to take part in the compartmentalization, proliferation, survival, and differentiation of cells.
DeVeale, B., Willaime-Morawek, S., van der Kooy, D., Balenci, L., Karpowicz, P., Inoue, T.   +5 more
core   +1 more source

Three-Dimensional Culture of Mouse Spermatogonial Stem Cells Using A Decellularised Testicular Scaffold [PDF]

Cell Journal, 2019
Objective: Applications of biological scaffolds for regenerative medicine are increasing. Such scaffolds improve cell attachment, migration, proliferation and differentiation. In the current study decellularised mouse whole testis was used as a natural
Nasrin Majidi Gharenaz, Mansoureh Movahedin, Zohreh Mazaheri   +2 more
doaj   +1 more source

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse [PDF]

, 2011
A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients.
Merlos-Suárez, Anna, Sancho, Elena, Munoz, P., Clevers, Hans, Barriga de Vicente, Francisco Martín, 1983-, Rossell, D., Mangues, Ramón, Marta Sevillano, David Rossell, Xavier Hernando-Momblona, Muñoz, Purificación, Batlle Gómez, Eduard, Sevillano, M., Victoria da Silva-Diz, Hans Clevers, María Virtudes Céspedes, Rossell, David, Sevillano, Marta, Merlos-Suarez, A., Céspedes, María Virtudes, da Silva-Diz, V., Silva-Diz, Victoria da, Sancho, E., Iglesias, M., Clevers, H., Mar Iglesias, Eduard Batlle, Barriga, F.M., Jung, Peter, Purificación Muñoz, Peter Jung, Hernando-Momblona, Xavier, da Silva-Diz, Victoria, Iglesias, Mar, Hernando-Momblona, X., Francisco M. Barriga, Iglesias Coma, Mar, Jung, P., Cespedes, M.V., Anna Merlos-Suárez, Batlle, E., Barriga, Francisco M., Batlle, Eduard, Elena Sancho, Mangues, R., Ramón Mangues   +45 more
core   +1 more source

Culture and transplantation of spermatogonial stem cells

Stem Cell Research, 2018
The spermatogonial transplantation technique was developed by Dr. Ralph Brinster in 1994. Transplanted spermatogonial stem cells (SSCs) produce germ cell colonies after microinjection into the seminiferous tubules of infertile mice.
Seiji Takashima, Takashi Shinohara
doaj   +1 more source

Mechanistic target of rapamycin kinase (Mtor) is required for spermatogonial proliferation and differentiation in mice

Asian Journal of Andrology, 2020
Spermatogonial development is a vital prerequisite for spermatogenesis and male fertility. However, the exact mechanisms underlying the behavior of spermatogonia, including spermatogonial stem cell (SSC) self-renewal and spermatogonial proliferation and ...
Jun Cao, Zuo-Bao Lin, Ming-Han Tong, Yong-Lian Zhang, Yi-Ping Li, Yu-Chuan Zhou   +5 more
doaj   +1 more source

Spermatogonial stem cells: Progress and prospects

Asian Journal of Andrology, 2015
Twenty years ago, the transplantation of spermatogonial stem cells (SSCs) from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs.
Mitsuru Komeya, Takehiko Ogawa
doaj   +1 more source

Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration

Frontiers in Endocrinology, 2022
Spermatogonial stem cells (SSCs) are a group of adult stem cells in the testis that serve as the foundation of continuous spermatogenesis and male fertility.
Lei Diao, Paul J. Turek, Constance M. John, Fang Fang, Renee A. Reijo Pera, Renee A. Reijo Pera   +5 more
doaj   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source