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2013
Spermatogonial stem cells (SSCs) constitute one of the most important stem cell systems in the adult body. SSCs are unipotent and respond for spermatogenesis in the male as they can only differentiate into sperms within the testicular niche. The long-term culture of SSCs without loss of their properties provides the opportunity to develop therapeutic ...
Ilya Chuykin +2 more
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Spermatogonial stem cells (SSCs) constitute one of the most important stem cell systems in the adult body. SSCs are unipotent and respond for spermatogenesis in the male as they can only differentiate into sperms within the testicular niche. The long-term culture of SSCs without loss of their properties provides the opportunity to develop therapeutic ...
Ilya Chuykin +2 more
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1993
Abstract Spermatogonial stem cells are responsible for the maintenance of spermatogenesis in the adult mammal. Knowledge of their regulation is important to understand the initiation of normal spermatogenesis, its recovery after toxic insults, and the modulation of fertility.
Marvin L Meistrich, Maria E A B van Beek
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Abstract Spermatogonial stem cells are responsible for the maintenance of spermatogenesis in the adult mammal. Knowledge of their regulation is important to understand the initiation of normal spermatogenesis, its recovery after toxic insults, and the modulation of fertility.
Marvin L Meistrich, Maria E A B van Beek
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Is There a Clinical Future for Spermatogonial Stem Cells?
Current Stem Cell Research & Therapy, 2007Like every other adult stem cell in the human body, spermatogonial stem cells (SSCs) have the capacity to either renew themselves or to start the differentiation process, namely, spermatogenesis. Due to the continuation of the stem cell population in the testis, several possible options for preservation and re-establishment of the reproductive ...
Ellen, Goossens +3 more
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Spermatogonial stem‐cell renewal in the mouse
The Anatomical Record, 1971AbstractType A spermatogonia in the mouse can be separated into five successive classes on the basis of nuclear morphology and stage of the cycle in which they occur. Enumeration of all types throughout the cycle of the seminiferous epithelium reveals that the As spermatogonia are the stem cells.
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Spermatogonial Stem Cell Transplantation to the Testis
Cold Spring Harbor Protocols, 2017Spermatogonial stem cells (SSCs) are located in the basal region of the seminiferous tubules and provide a self-renewing reservoir from which progenitor spermatogonia arise and transiently amplify in number before transition to a differentiating state.
Shaun, Goodyear, Ralph, Brinster
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Regulation of the proliferation of spermatogonial stem cells
Journal of Cell Science, 1988ABSTRACT The proliferating cells in the seminiferous epithelium can be subdivided into the (morphologically) undifferentiated and the differentiating spermatogonia. In turn the undifferentiated spermatogonia can be subdivided according to their topographical arrangement into clones consisting of one cell, the A-single (As) spermatogonia,
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Advances in spermatogonial stem cell transplantation
Reviews of Reproduction, 2000Spermatogonial stem cell transplantation was first reported by Ralph Brinster's laboratory in 1994. It has proven to be a technological breakthrough in the study of both stem cells and Sertoli cell-germ cell interactions. This technique can be used to transfer testicular stem cells successfully from one animal to another of the same species (referred ...
D S, Johnston +2 more
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Cryopreserving and Thawing Spermatogonial Stem Cells
Cold Spring Harbor Protocols, 2017Spermatogonial stem cells (SSCs) can be cryopreserved and stored in liquid nitrogen, using relatively standard cryopreservation techniques. At a subsequent time, they can be thawed for subsequent culture and expansion and then transplanted to generate spermatogenesis.
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Spermatogonial stem cell preservation and transplantation
Molecular and Cellular Endocrinology, 2002Spermatogonia are the male germ line stem cells. Their life long expansion is needed for permanent production of male germ cells. Spermatogonia are the only cells of the germ line, which proliferate in adulthood and offer interesting applications as they are potentially totipotent and immortal cells.
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Spermatogonial Kök Hücre / Spermatogonial Stem Cell
2017Spermatogonial stem cells (SSC) found in male testis is a kind of adult stem cell. These pluripotent cells having self-renewal and differentiation capacity are unique since they genetically contribute to the next generation. Recent studies which have been done on the isolation, characterization and transplantation of SSCs enabled to understand SSC ...
YANAR, Sevinç +3 more
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