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2006
The biological activities of spermatogonial stem cells (SSCs) are the foundation for spermatogenesis and thus sustained male fertility. Therefore, understanding the mechanisms governing their ability to both self-renew and differentiate is essential.
Jon M, Oatley, Ralph L, Brinster
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The biological activities of spermatogonial stem cells (SSCs) are the foundation for spermatogenesis and thus sustained male fertility. Therefore, understanding the mechanisms governing their ability to both self-renew and differentiate is essential.
Jon M, Oatley, Ralph L, Brinster
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Spermatogonial Stem Cell Development
2002Spermatogonial stem cells originate from primordial germ cells (PGCs) that derive from epiblast cells (embryonal ectoderm) (Lawson and Pederson 1992). During fetal development the PGCs proliferate and migrate to the genital ridges, where they become enclosed in the seminiferous cords formed by Sertoli cell precursors.
de Rooij, D.G. +3 more
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Fertility restoration with spermatogonial stem cells
Current Opinion in Endocrinology, Diabetes & Obesity, 2017Purpose of review This review evaluates the state of the art in terms of challenges and strategies used to restore fertility with spermatogonial stem cells retrieved from prepubertal boys affected by cancer. Although these boys do not yet produce spermatozoa, the only option to preserve their fertility is cryopreservation of ...
Francesca, de Michele +2 more
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Spermatogonial stem cells in the albino rat
American Journal of Anatomy, 1975AbstractThe existence of two classes of spermatogonial stem cells in the rat testis, i.e., reserve type A0 spermatogonia and renewing, types A1‐A4 spermatogonia, postulated by Clermont and Bustos‐Obregon (′68), was reexamined in a quantitative analysis of type A spermatogonia in both whole mounts of tubules and in radioautographed sections of testes ...
Y, Clermont, L, Hermo
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The spermatogonial stem cell niche
Microscopy Research and Technique, 2009AbstractSpermatogonial stem cells (SSCs; As spermatogonia) and their direct descendants (Apr and Aal spermatogonia) are preferentially located in those areas of the seminiferous tubules that border on the interstitial tissue. Fewer of these cells are present in tubule areas directly bordering on another tubule.
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Spermatogonial stem cells: unlimited potential
Reproduction, Fertility and Development, 2008Recent reports have demonstrated that adult cells can be reprogrammed to pluripotency, but mostly with genes delivered using retroviruses. Some of the genes are cancer causing; thus, these adult-derived embryonic stem (ES)-like cells cannot be used for therapy to cure human diseases.
M, Dym +4 more
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Avian Biology Research, 2011
Testicular gonocytes differentiate into spermatogonia, and spermatogonial stem cells could be established by culturing spermatogonia in vitro. Testicular and ovarian gonocytes were identified as relatively large cells in a population of gonadal cells.
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Testicular gonocytes differentiate into spermatogonia, and spermatogonial stem cells could be established by culturing spermatogonia in vitro. Testicular and ovarian gonocytes were identified as relatively large cells in a population of gonadal cells.
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2012
The process of spermatogenesis is initiated and maintained by a rare population of single spermatogonial stem cells (SSCs). The SSCs are attached to the basement membrane of the seminiferous tubules and are characterized by typical morphological criteria.
Hossein Azizi +3 more
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The process of spermatogenesis is initiated and maintained by a rare population of single spermatogonial stem cells (SSCs). The SSCs are attached to the basement membrane of the seminiferous tubules and are characterized by typical morphological criteria.
Hossein Azizi +3 more
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Cryopreservation and Transplantation of Spermatogonial Stem Cells
2021Cryopreservation as a method that enables long-term storage of biological material has long been used for the conservation of valuable zebrafish genetic resources. However, currently, only spermatozoa of zebrafish can be successfully cryopreserved, while protocols for cryopreservation of eggs and embryos have not yet been fully developed ...
Zoran, Marinović +6 more
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Heterogeneity of Spermatogonial Stem Cells
2019Germ cells transfer genetic materials from one generation to the next, which ensures the continuation of the species. Spermatogenesis, the process of male germ cell production, is one of the most productive systems in adult tissues. This high productivity depends on the well-coordinated differentiation cascade in spermatogonia, occurring via their ...
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