Results 101 to 110 of about 34,064 (250)
Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors
International Journal of Cancer, Volume 159, Issue 12, Page 3038-3048, 15 December 2026.ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan +6 more
wiley +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 6, December 2026.ABSTRACT We previously developed nanobodies acting as positive allosteric modulators (PAMs) of the calcium‐sensing receptor (CaSR). Here, we sought to develop more potent CaSR modulators by creating bivalent nanobody constructs using ‘tail‐to‐head’ peptide‐linker conjugation.
Mahdis Nabipour +5 more
wiley +1 more source
Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production
Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3152-3164, November 2026.ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise +3 more
wiley +1 more source
Spermine Stimulates The Threonyl-trna Formation In Rat Liver.
, 2015 The effects of spermine have been studied on the aminoacylation reaction catalyzed by rat liver threonyl-tRNA synthetase. Spermine can not replace Mg2+ in this reaction.
Aoyama, H
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Effect of DFMO and spermine supplementation on Active Rap-1 protein levels.
, 2013 Neither DFMO nor spermine activated Rap-1. negative control: cell lysate treated with GDP. positive control: cell lysate treated with GTP-gamma-S. no treatment: cell lysate with no treatment. DFMO: lysate of cells cultured with 3 mM DMFO.
Fumio Konishi (283703) +2 more
core +1 more source
The effect of spermine on the initiation of mitochondrial protein synthesis [PDF]
, 2009 Polyamines are important in both prokaryotic and eukaryotic translational systems. Spermine is a quaternary aliphatic amine that is cationic under physiological conditions.
Spremulli, Linda L. +5 more
core +1 more source
MedComm, Volume 7, Issue 11, November 2026.Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen +3 more
wiley +1 more source
Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis
Immunology, Volume 179, Issue 3, Page 418-433, November 2026.Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao +16 more
wiley +1 more source
Spermine-modified Antheraea pernyi silk fibroin as a gene delivery carrier
, 2016 Yanni Yu,1 Yongpei Hu,1 Xiufang Li,1 Yu Liu,1 Mingzhong Li,1 Jicheng Yang,2 Weihua Sheng2 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, 2Cell and Molecular Biology Institute, College ...
Sheng W +6 more
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