Results 121 to 130 of about 34,064 (250)

Spermine Regulates Bone Homeostasis Through The Gut-Bone Axis

International Dental Journal
Aim or purpose: This study aims to explore the specific mechanism by which spermine, a metabolite highly expressed in the saliva of patients with MRONJ, regulates bone homeostasis through the gut-bone axis.
Ruixue Jiang, Yuwei Deng
doaj   +1 more source

Effect of spermine administration on pancreatic maturation in unweaned rats.

, 1998
Department of Biochemistry and General Physiology, University of Liege, Belgium. The effect of oral administration of spermine on pancreatic maturation was investigated in the suckling rat.
Leroy, O., Forget, Ph., Dandrifosse, G., Romain, N., N Romain, M.S Gesell, O Leroy, P Forget, Gesell, M.S., G.D Luk, Luk, G.D., G Dandrifosse   +11 more
core   +1 more source

The MFS transporter BcTpo1 governs the oxidative stress response and infection of Botrytis cinerea

Crop Health
Botrytis cinerea is a devastating necrotrophic pathogen causing gray mold disease. Understanding its pathogenic mechanisms is critical for developing novel control strategies. In this study, we investigated the role of spermine and its transporter BcTpo1
Lingchao Wang, Youmei Xie, Jiaxuan Li, Fugen Yang, Wenxing Liang, Qianqian Yang   +5 more
doaj   +1 more source

The Crystal Structure of Spermidine/Spermine N¹-Acetyltransferase in Complex with Spermine Provides Insights into Substrate Binding and Catalysis^,

, 2016
The enzyme spermidine/spermine N1-acetyltransferase (SSAT) catalyzes the transfer of acetyl groups from acetylcoenzyme A to spermidine and spermine, as part of a polyamine degradation pathway.
Eric J. Montemayor (1508032), David W. Hoffman (2329354)   +1 more
core   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Spermine driven water deficit tolerance in early growth phases of sweet corn genotypes under hydroponic cultivation

Scientific Reports
Sweet corn is highly susceptible to water deprivation, making it crucial to identify effective strategies for enhancing its tolerance to water deficit conditions.
Tahoora Batool Zargar, Mawia Sobh, Oqba Basal, Tibor Janda, Magda Pál, Szilvia Veres   +5 more
doaj   +1 more source

Chiral configurations of spermine-bridged cyclotriphosphazatrienes

, 2002
Spermine-bridged gem-disubstituted cyclotriphosphazatrienes have been synthesised by two routes. In one route a spermine-bridged cyclophosphazene 2 reacted with monofunctional nucleophiles known to favour gem disubstitution in cyclophosphazene rings (e ...
Davies, David B., Hursthouse, Michael B., Shaw, Robert A., Yenilmez, Gönül, Kiliç, Adem, Coles, Simon J., Eaton, Robert J., Mayer, Thomas A., Thomas A. Mayer, Robert A. Shaw, Robert J. Eaton, David B. Davies, Simon J. Coles, Gönül Yenilmez, Adem Kiliç, Michael B. Hursthouse   +15 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2289-2308, October 2026.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

Kinetic analysis of spermine binding to NRD convertase

, 1999
N-arginine dibasic convertase cleaves polypeptides between paired basic residues containing the sequence Arg-Arg or Arg-Lys. the enzyme contains a large anionic domain, which in the rat enzyme consists of 57 acidic residues out of a stretch of 76 amino ...
Csuhai, E., Hersh, L. B., Juliano, M. A., Juliano, L.   +3 more
core   +1 more source