Results 141 to 150 of about 34,064 (250)

Alterations of renal polyamine metabolism in mice with folic acid-induced chronic kidney disease

Biochemistry and Biophysics Reports
Chronic kidney disease (CKD) often follows acute kidney injury, leading to renal fibrosis and progressive renal failure. Spermine, a polyamine with antioxidant and anti-inflammatory properties, helps reduce renal fibrosis and may serve as a biomarker for
Cheng Xue, Jiaxin Chen, Xinming Li, Chenchen Zhou, Zhiguo Mao   +4 more
doaj   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

HS‐AFM Reveals Hierarchical RNA Folding Driving Condensate Assembly and Material States

Small, Volume 22, Issue 60, 27 October 2026.
High‐speed atomic force microscopy reveals the nanoscale pathway of RNA condensate formation, from individual RNA folding to higher‐order assembly. Quantitative analyses of fusion dynamics and nanomechanical properties distinguish liquid‐like poly A condensates from solid‐like total RNA assemblies, providing a direct link between RNA self‐assembly and ...
S. M. Neaz Mahmud, Kenichi Umeda, Tamoghna Das, Nadia Shoukat, Noriyuki Kodera, Hanae Sato   +5 more
wiley   +1 more source

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies

Aging Cell, Volume 25, Issue 10, October 2026.
AMP‐activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direct pharmacological activation of AMPK with the compound 991 in vivo extends lifespan in multiple model organisms: the fission yeast Schizosaccharomyces ...
Eliano dos Santos, Marie Blickling, Fiona C. Leiper, John‐Patrick Alao, Claudia Lennicke, Andrea Foley, Jon R. Wilson, Steven J. Gamblin, Bénédicte Chazaud, Giovanna Lollo, Rémi Mounier, Gaëtan Juban, Charalampos Rallis, David Carling, Filipe Cabreiro, Helena M. Cochemé   +15 more
wiley   +1 more source

New routes for spermine biosynthesis

Journal of Biological Chemistry
The polyamine spermine (Spm) is a flexible linear teraamine found in bacteria and eukaryotes and in all known cases is synthesized from triamine spermidine by addition of an aminopropyl group acquired from decarboxylated S-adenosylmethionine (dcAdoMet).
Li, Bin, Baniasadi, Hamid R., Liang, Jue, Phillips, Margaret A., Michael, Anthony J.   +4 more
openaire   +2 more sources

Spermine-mediated Casein Kinase II-uptake By Rat-liver Mitochondria

, 1994
Spermine, ubiquitous intracellular polyamine, is able to promote the transmembrane translocation of casein kinase CKII through the outer membrane of rat liver mitochondria and its binding to more internal mitochondrial structures.
CLARI, GIULIO, F. CATTAPAN, N. SILIPRANDI, MORET, VITTORIO, BORDIN, LUCIANA, TONINELLO, ANTONIO   +5 more
core   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, Volume 59, Issue 10, October 2026.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Huangqi Guizhi Wuwu Decoction Ameliorates Cachexia in Lung Cancer Mice Through Regulating Amino Acid Metabolism: Insights From Transcriptomics, Metabolomics and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACTThe effects and mechanisms of Huangqi Guizhi Wuwu Decoction (HGWD) in cancer cachexia remain unclear. We generated an in vivo cachexia model by implanting Lewis lung carcinoma cells into mice and treated animals with HGWD. We evaluated muscle function using grip strength and wire‐grip tests.
Yingjia Zhou, Shaoli Zhao, Hongmei Shen, Jia Wu, Mei Li, Shan Liu, Jian Yang, Xiaowei Jin, Fan Li, Huantian Cui   +9 more
wiley   +1 more source

The Effect of Seed Priming with Polyamine Spermine on Key Photosynthetic Parameters in Fusarium culmorum Infected Winter Wheat

Agronomy
Photosynthesis is a primary plant physiological process, which can easily be affected by various environmental factors, including biotic stressors. The exogenous application of different substances like plant growth regulators might benefit this process ...
Dessislava Todorova, Tsvetina Nikolova, Iskren Sergiev, Svetoslav Anev   +3 more
doaj   +1 more source

Clinical Significance of Serum Spermine in Breast Cancer

, 1988
The diagnostic significance of three polyamines (putrescine, spermidine and spermine), of carcinoembryonic antigen and of phosphoglucose isomerase have been compared in sera of patients with breast cancer or benign breast disease and normal age matched ...
I. Mittra, Nitin A. Inamdar, Shrikrishna R. Damle, Suhas L. Redkar   +3 more
core   +1 more source