Results 91 to 100 of about 176,600 (181)

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam, Anas Shamsi, Syed Tasqeruddin, Moyad Shahwan   +3 more
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Skeletal muscle‐specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice

Experimental Physiology, Volume 111, Issue 7, Page 3357-3380, 1 July 2026.
Abstract In addition to controlling muscle mass, myostatin may support oxidative metabolism and endurance. Loss of function through gene knockout or post‐natal blockade generally lowers muscle oxidative capacity and increases fatigability. These observations imply that myostatin activation could promote a more oxidative and less fatigable muscle ...
Andy V. Khamoui, Andrea Abraham, Janos Porszasz, Istvan Kovanecz, Silvana Constantinescu, Harry B. Rossiter, Suzanne Reisz‐Porszasz   +6 more
wiley   +1 more source

Spermine is not essential for survival of Arabidopsis [PDF]

, 2004
Spermine is the final product of the polyamine biosynthetic pathway and is ubiquitously present in most organisms. The genome of Arabidopsis thaliana has two genes encoding spermine synthase: ACAULIS5 (ACL5), whose loss-of-function mutants show a severe ...
Akihiro Imai, Taku Takahashi, Shusei Sato, Imai, Akihiro, Satoshi Tabata, Kotaro T Yamamoto, Sato, Shusei, Akiyama, Takashi, Takashi Akiyama, Yamamoto, Kotaro T, Takahashi, Taku, Tabata, Satoshi, Kato, Tomohiko, Tomohiko Kato   +13 more
core   +1 more source

Effect of Nitric Oxide Fumigation Combined with Hypobaric Treatment on the Postharvest Quality and Metabolism of Polyamines and Glutathione in Xiaobai Apricots [PDF]

Shipin Kexue
To investigate the regulatory effect of nitric oxide (NO) fumigation combined with hypobaric treatment (HYT) on the postharvest quality of Xiaobai apricots, ‘Luntai’ apricots were treated with exogenous NO under hypobaric conditions (HYT + NO).
LIU Yongli, ZHANG Yu, FENG Yudie, MA Lichun, ZHOU Shengchang, WEI Jia, WU Bin, YANG Yang
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Integrative analysis of polyamine metabolism-related genes in gliomas: implications for prognosis and therapy

Frontiers in Oncology
IntroductionTumor transformation and progression are accompanied by multiple carcinogenic pathways that dysregulate polyamine demand and metabolism. The importance of polyamines has demonstrated that their metabolism is a potential therapeutic strategy ...
Yujia Zhao, Yujia Zhao, Zhenkai Fu, Sijie Chen, Fei Li, Xiaoyu Zhang, Kaidiriye Setiwalidi, Zhiping Ruan, Yu Yao, Lanxin Luo   +9 more
doaj   +1 more source

Investigating Mechanisms of Impaired Mineralization Due to Deficient Spermine Synthase Activity [PDF]

Despite the relevance of polyamines to many forms of life, little is known about how polyamines regulate osteogenesis and skeletal homeostasis. Here, we report a series of in vitro studies conducted with human-bone-marrow-derived multipotent stromal ...
Cressman, Amin Sebastian
core  

Spermine causes loss of innate immune response to helicobacter pylori by inhibition of inducible nitric-oxide synthase translation

, 2005
Helicobacter pylori infection of the stomach elicits a vigorous but ineffective host immune and inflammatory response, resulting in persistence of the bacterium for the life of the host. We have reported that in macrophages, H.
Bussière, Françoise, Asim, Mohammed, Gobert, Alain, Kim, Preston, Blumberg, Darren, Chaturvedi, Rupesh, Cheng, Yulan, Xu, Hangxiu, Hacker, Amy, Casero, Robert, Wilson, Keith   +10 more
core   +1 more source

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance [PDF]

, 2004
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Meja Rabodonirina, Chiara Atzori, Benfield, T, Helweg-Larsen, J, Rabodonirina, Meja, Robert Miller, Crothers, KA, Thomas Benfield, Huang, Laurence, Atzori, C, Rabodonirina, M, Laurence Huang, Kristina Crothers, Miller, R, Haung, L, Helweg-Larsen, Jannik, Jannik Helweg-Larsen, Miller, Robert, Crothers, Kristina, Benfield, Thomas, Atzori, Chiara   +20 more
core   +1 more source