Results 91 to 100 of about 321,693 (208)

Correlation between endogenous polyamines in human cardiac tissues and clinical parameters in patients with heart failure [PDF]

, 2016
This work was supported by a grant from the Instituto de Salud Carlos III(FISS03-1497), from which Clara Meana was recipient of a fellowships. CM, CB and LS designed and performed the biochemical experiments, JB designed and performed the experiments of ...
Bordallo Landa, Javier, Bordallo Landa, María del Carmen, Meana González, Clara, Rubín López, José Manuel, Suárez García, Lorena, Sánchez Fernández, Manuel   +5 more
core   +2 more sources

Skeletal muscle‐specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice

Experimental Physiology, EarlyView.
Abstract In addition to controlling muscle mass, myostatin may support oxidative metabolism and endurance. Loss of function through gene knockout or post‐natal blockade generally lowers muscle oxidative capacity and increases fatigability. These observations imply that myostatin activation could promote a more oxidative and less fatigable muscle ...
Andy V. Khamoui, Andrea Abraham, Janos Porszasz, Istvan Kovanecz, Silvana Constantinescu, Harry B. Rossiter, Suzanne Reisz‐Porszasz   +6 more
wiley   +1 more source

Effect of salinity on polyamines and ethylene in Atriplex prostrata and Plantago coronopus

Biologia Plantarum, 2015
The aim of this study was to investigate the effects of salinity on germination, seedling growth, free polyamines (putrescine, spermidine, and spermine), and ethylene metabolism of two species (Atriplex prostrata Bouchér and Plantago coronopus L.) with ...
M. Bueno, Ma. L. Lendínez, C. Aparicio, Ma. P. Cordovilla   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Enhancing Human Spermine Synthase Activity by Site Directed Mutations [PDF]

Biophysical Journal, 2013
Spermine Synthase (SMS) is an enzyme converting spermidine into spermine, both of which are polyamines controlling normal cell growth and development. Several missense mutations in human SMS (HsSMS) are known to cause Snyder-Robinson Syndrome (SRS) by either destabilizing the monomer/dimer conformation or directly affecting the hydrogen bond network in
Zhe Zhang, A. Pegg, Yoshihiko Ikeguchi, E. Alexov   +3 more
semanticscholar   +2 more sources

Snyder-Robinson syndrome presenting with learning disability, epilepsy, and osteoporosis: A novel SMS gene variant

Rare
Snyder-Robinson syndrome (SRS) is a rare X-linked recessive disorder characterized by a collection of clinical features including mild to severe intellectual disability, hypertonia, marfanoid habitus, facial asymmetry, osteoporosis, developmental delay ...
Megumi Leung, Meredith Sanchez-Castillo, Newell Belnap, Marcus Naymik, Anna Bonfitto, Jennifer Sloan, Katie Hassett, Wayne M. Jepsen, Aravind Sankaramoorthy, Tracy Murray Stewart, Jackson R. Foley, Sampathkumar Rangasamy, Matthew J. Huentelman, Vinodh Narayanan, Keri Ramsey   +14 more
doaj   +1 more source

CA2 Pyramidal Layer [PDF]

, 2008
This report contains a gene expression summary of the CA2 pyramidal cell layer (CA2sp), derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set.
Allen Institute for Brain Science, Angela L. Guillozet-Bongaarts, Lydia L. Ng, Rachel A. Dalley   +3 more
core   +2 more sources

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4139-4158, June 2026.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Overexpression of wheat spermidine synthase gene enhances wheat resistance to Fusarium head blight

Phytopathology Research
Polyamines, such as putrescine, spermidine, and spermine, are crucial for plant defense against both abiotic and biotic stresses. Putrescine is also known as a significant inducer of deoxynivalenol (DON) production in Fusarium graminearum, the primary ...
Jingyi Ren, Chengliang Li, Qi Xiu, Ming Xu, Huiquan Liu   +4 more
doaj   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source