Results 61 to 70 of about 176,600 (181)

Spermine-NBD as Fluorescent Probe for Studies of Polyamine Transport System in Leishmania Donovani

, 2018
This study describes the synthesis of fluorescent probes as potential substrates for the polyamine transport system (PTS) of Leishmania donovani. A competitive radioassay was used to determine the most efficient probe.
Raphael LABRUERE (5724446), Elodie Jagu (5855359), Jean-Christophe Cintrat (5855368), stéphanie Pethe (5855360), Philippe M. Loiseau (5855369), Sébastien Pomel (5855349)   +5 more
core   +1 more source

Abnormal Polyamine Metabolism in Pancreatic Epithelial Cells aggravates chronic pancreatitis-associated preneoplastic lesions

Frontiers in Bioscience-Landmark
Background:Chronic pancreatitis (CP) is an independent risk factor for pancreatic cancer (PC). Investigation of the pathological progression of CP may help to elucidate the mechanisms underlying the progression of preneoplastic lesions in CP.Methods ...
Yuhong Zhang, Hongbin Wang, Xiaxia Shao, Yang Ling, Yongping Liu   +4 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson’s Disease

npj Parkinson's Disease
Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by α-synuclein accumulation and aggregation, leading to disrupted cellular homeostasis, impaired mitochondrial function, and neuroinflammation, ultimately causing neuronal death ...
Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Zaina Qadri, Nazin N. Islam, Sokol V. Todi, Peter A. LeWitt, Wei-Ling Tsou   +7 more
doaj   +1 more source

Arbuscular Mycorrhizal Fungi Regulate Polyamine Homeostasis in Roots of Trifoliate Orange for Improved Adaptation to Soil Moisture Deficit Stress

Frontiers in Plant Science, 2021
Soil arbuscular mycorrhizal fungi (AMF) enhance the tolerance of plants against soil moisture deficit stress (SMDS), but the underlying mechanisms are still not fully understood. Polyamines (PAs) as low-molecular-weight, aliphatic polycations have strong
Ying-Ning Zou, Fei Zhang, Anoop K. Srivastava, Qiang-Sheng Wu, Qiang-Sheng Wu, Kamil Kuča   +5 more
doaj   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

The Spermine Synthase OsSPMS1 Regulates Seed Germination, Grain Size, and Yield [PDF]

Plant Physiology, 2018
Polyamines, including putrescine, spermidine, and spermine, play essential roles in a wide variety of prokaryotic and eukaryotic organisms. Rice (Oryza sativa) contains four putative spermidine/spermine synthase (SPMS)-encoding genes (OsSPMS1, OsSPMS2, OsSPMS3, and OsACAULIS5), but none have been functionally characterized.
Yajun Tao, Jun Wang, Jun Miao, Jie Chen, Shujun Wu, Jinyan Zhu, Dongping Zhang, Houwen Gu, Huan Cui, Shuangyue Shi, Mingyue Xu, Youli Yao, Zhiyun Gong, Zefeng Yang, Minghong Gu, Yong Zhou, Guohua Liang   +16 more
openaire   +2 more sources

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Spermine Synthase Deficiency Leads to Deafness and a Profound Sensitivity to α-Difluoromethylornithine* [PDF]

Journal of Biological Chemistry, 2009
Male gyro (Gy) mice, which have an X chromosomal deletion inactivating the SpmS and Phex genes, were found to be profoundly hearing impaired. This defect was due to alteration in polyamine content due to the absence of spermine synthase, the product of the SpmS gene.
Xiaojing, Wang, Snezana, Levic, Michael Anne, Gratton, Karen Jo, Doyle, Ebenezer N, Yamoah, Anthony E, Pegg   +5 more
openaire   +2 more sources

Assembly of the eukaryotic PLP-synthase complex from plasmodium and activation of the Pdx1 enzyme [PDF]

, 2012
Biosynthesis of vitamins is fundamental to malaria parasites. Plasmodia synthesize the active form of vitamin B6 (pyridoxal 5-phosphate, PLP) using a PLP synthase complex.
Böttcher, Bettina, Derrer, Bianca, Windeisen, Volker, Hipp, Katharina, Tews, Ivo, Sinning, Irmgard, Kappes, Barbara, Boettcher, Bettina, Gengenbacher, Martin, Guedez, Gabriela   +9 more
core   +1 more source