Results 51 to 60 of about 321,693 (208)

Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells [PDF]

, 2007
Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis. Studies have established a direct role for nitric oxide (NO) in the regulation of gene expression in mesangial cells.
Banas B., Bannenberg G., Davies M., Gabbai F.B., Guzik T.J., Habib R., Huang S., Hubank M., Ohno M., Rangan G.K., Rosenberg H.G., Stengel B.   +11 more
core   +1 more source

The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei

Biomolecules, 2023
The triamine spermidine is a key metabolite of the polyamine pathway. It plays a crucial role in many infectious diseases caused by viral or parasitic infections.
Annette Kaiser
doaj   +1 more source

Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis. [PDF]

, 2017
Helicobacter pylori is a gram-negative, microaerophilic bacterium that infects the stomach and can lead to, among other disorders, the development of gastric cancer. The inability of the host to clear the infection results in a chronic inflammatory state
Butcher, Lindsay D, Crowe, Sheila E, den Hartog, Gerco, Ernst, Peter B   +3 more
core   +2 more sources

Characterization of Spermidine Synthase (SPDS) Gene and RNA−Seq Based Identification of Spermidine (SPD) and Spermine (SPM) Involvement in Improving High Temperature Stress Tolerance in Gracilariopsis lemaneiformis (Rhodophyta)

Frontiers in Marine Science, 2022
Gracilariopsis lemaneiformis, an important commercial red macroalga, is facing significant impacts from global warming, which limits algal growth and yield in China.
Shixia Liu, Jun Zhang, Xue Sun, Nianjun Xu   +3 more
semanticscholar   +1 more source

Polyamine Homeostasis in Snyder-Robinson Syndrome

Medical Sciences, 2018
Loss-of-function mutations of the spermine synthase gene (SMS) result in Snyder-Robinson Syndrome (SRS), a recessive X-linked syndrome characterized by intellectual disability, osteoporosis, hypotonia, speech abnormalities, kyphoscoliosis, and seizures ...
Tracy Murray-Stewart, Matthew Dunworth, Jackson R. Foley, Charles E. Schwartz, Robert A. Casero   +4 more
doaj   +1 more source

The dwarf phenotype of the Arabidopsis acl5 mutant is suppressed by a mutation in an upstream ORF of a bHLH gene [PDF]

, 2006
Loss-of-function mutants of the Arabidopsis thaliana ACAULIS 5 (ACL5) gene, which encodes spermine synthase, exhibit a severe dwarf phenotype. To elucidate the ACL5-mediated regulatory pathways of stem internocle elongation, we isolated four suppressor ...
Hanzawa, Yoshie, Imai, Akihiro, Komeda, Yoshibumi, Komura, Mio, Takahashi, Taku, Yamamoto, Kotaro T.   +5 more
core   +1 more source

Perturbation of spermine synthase Gene Expression and Transcript Profiling Provide New Insights on the Role of the Tetraamine Spermine in Arabidopsis Defense against Pseudomonas viridiflava1[C][W] [PDF]

, 2011
The role of the tetraamine spermine in plant defense against pathogens was investigated by using the Arabidopsis (Arabidopsis thaliana)-Pseudomonas viridiflava pathosystem.
Blázquez, Miguel Angel, Carbonell, Juan, Carrasco Sorli, Pedro M., Gonzalez, María Elisa, Gómez Minguet, Eugenio, Marco, Francisco, Pieckenstain, Fernando Luis, Ruiz, Oscar Adolfo   +7 more
core   +1 more source

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes [PDF]

, 2009
Impaired adipogenesis has been shown to predispose to disturbed adipocyte function and development of metabolic abnormalities. Previous studies indicate that polyamines are essential in the adipogenesis in 3T3-L1 fibroblasts.
Ausubel, Bays, Bays, Bethell, Erwin, Feve, Giles, Grigorenko, Hyvönen, Hyvönen, Jell, Keinänen, Nishimura, Park, Park, Pirinen, Ramirez-Zacarias, Rosen, Student, Taylor, Teti, Tjabringa, Tjabringa, Vazquez-Vela   +23 more
core   +1 more source

Overexpression of SMS in the tumor microenvironment is associated with immunosuppression in hepatocellular carcinoma

Frontiers in Immunology, 2022
Disorders of polyamine metabolism may contribute to the development of hepatocellular carcinoma (HCC), but the precise mechanism remains unknown.
Lin Xiang, Longhuan Piao, Dong Wang, Li-Feng-Rong Qi   +3 more
doaj   +1 more source

Methylthioadenosine [PDF]

, 2004
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. MTA is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory ...
Avila, M.A. (Matías Antonio), Corrales, F.J. (Fernando José), Lu, S.C. (Shelly C.), Mato, J.M. (José María), Ruiz Garcia-Trevijano, E. (Elena)   +4 more
core   +1 more source