Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy
bioRxiv, 2023 Tauopathy, including Alzheimer Disease (AD), is characterized by Tau protein accumulation and autophagy dysregulation. Emerging evidence connects polyamine metabolism with the autophagy pathway, however the role of polyamines in Tauopathy remains unclear.
Xianzun Tao +6 more
semanticscholar +1 more source
Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene [PDF]
Human Molecular Genetics, 1998 Two mouse mutations gyro (Gy) and hypophosphatemia (Hyp) are mouse models for X-linked hypophosphatemic rickets and have been shown to be deleted for the 5' and 3' end of the mouse homolog of PHEX (phosphate regulating gene with homologies to endopeptidases on the X chromosome; formerly called PEX), respectively.
B, Lorenz +9 more
openaire +2 more sources
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome
EMBO Molecular Medicine, 2023 Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and
Tracy Murray Stewart +8 more
doaj +1 more source
Fluorinated analogues of spermidine as substrates of spermine synthase [PDF]
European Journal of Biochemistry, 1988 A series of mono‐and geminal difluorinated analogues of spermidine (4‐azaoctane‐1, 8‐diamine) have been tested as potential substrates of partially purified rat hepatoma (HTC) cell or pure bovine spleen spermine synthase (EC 2.5.1.22).Substitution of the hydrogen atoms of the methylene group at position 7 by one or two fluorine atoms decreases 8‐fold ...
J G, Baillon +4 more
openaire +2 more sources
Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]
, 2011 Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin +4 more
core +1 more source
Characterization of transgenic mice with widespread overexpression of spermine synthase [PDF]
Biochemical Journal, 2004 A widespread increase in SpmS (spermine synthase) activity has been produced in transgenic mice using a construct in which the human SpmS cDNA was placed under the control of a composite CMV-IE (cytomegalovirus immediate early gene) enhancer–chicken β-actin promoter. Four separate founder CAG/SpmS mice were studied.
Yoshihiko, Ikeguchi +7 more
openaire +2 more sources
Glutamate, Ornithine, Arginine, Proline, and Polyamine Metabolic Interactions: The Pathway Is Regulated at the Post-Transcriptional Level [PDF]
, 2016 The metabolism of glutamate into ornithine, arginine, proline, and polyamines is a major network of nitrogen-metabolizing pathways in plants, which also produces intermediates like nitric oxide, and γ-aminobutyric acid (GABA) that play critical roles in ...
Boubker eBarchi +7 more
core +4 more sources
The impact of spermine synthase (SMS) mutations on brain morphology [PDF]
neurogenetics, 2009 Snyder-Robinson syndrome (SRS) is a form of X-linked mental retardation resulting from mutations in spermine synthase (SMS), which impact neurodevelopment and cognitive outcome. We obtained cerebral, cerebellum, hippocampus, and red nucleus volumes from two males with SRS and 24 age- and gender-matched typically developing controls using volumetric ...
Shelli R, Kesler +3 more
openaire +2 more sources
Diatom Proteomics Reveals Unique Acclimation Strategies to Mitigate Fe Limitation [PDF]
, 2015 Phytoplankton growth rates are limited by the supply of iron (Fe) in approximately one third of the open ocean, with major implications for carbon dioxide sequestration and carbon (C) biogeochemistry.
Boyd, Philip W. +7 more
core +1 more source
In Silico Investigation of Mutability of Spermine Synthase [PDF]
Biophysical Journal, 2011 Spermine Synthase (SMS) is an enzyme which controls spermidine/spermine concentrations, both of which are polyamines playing an important role for cell development. Recently we have investigated the effect of missense mutations (G56S, V132G and I150T) known to cause Synder-Robinson Syndrome (SRS) on SMS stability and dynamics.
Zhang, Zhe +2 more
openaire +1 more source