Results 21 to 30 of about 176,600 (181)

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer

Nature Communications
While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients
Hanshen Yang, Xiaozhen Zhang, Sirui Zhang, Yanqing Yang, Yan Chen, Yangwei Jiang, Qingsong Lu, Lingyue Liu, Mengyi Lao, Weiran Du, Kang Sun, Lihong He, Jiatao Shi, Xinyuan Liu, Jinyuan Song, Na Lu, Junming Huang, Jinyan Huang, Ruhong Zhou, Xiongbin Lu, Tingbo Liang, Xueli Bai   +21 more
doaj   +2 more sources

Polyamine sequestration of 2′3′-cGAMP constrains intercellular transmission and STING engagement to subvert antitumor immunity [PDF]

The Journal of Clinical Investigation
The cyclic dinucleotide 2′3′–cyclic guanosine monophosphate–adenosine monophosphate (2′3′-cGAMP) serves as a central immunotransmitter that propagates stimulator of interferon gene–dependent (STING-dependent) innate immunity across tissues; however, how ...
Yunjin Ma, Chunyuan Zhao, Jiacheng Guo, Yue Fu, Wei Wang, Jiangong Zhang, Kun Zhao, Xiangbo Meng, Zhongshang Yuan, Chengjiang Gao, Mutian Jia, Ying Qin, Hui Song, Wei Zhao   +13 more
doaj   +2 more sources

Spermine and thermospermine synthases emerged multiple times during eukaryote evolution. [PDF]

J Biol Chem
The polyamines spermine and thermospermine are differentially distributed throughout eukaryotic phyla. It is unlikely that they were present in the Last Eukaryotic Common Ancestor, thus their biosynthetic enzymes, spermine synthase (SpmSyn) and thermospermine synthase (TspmSyn) emerged during eukaryotic evolution.
Li B, Liang J, Baniasadi HR, Phillips MA, Michael AJ.   +4 more
europepmc   +3 more sources

Polyamine Metabolism in Brain Health and Disease [PDF]

Neuropharmacology and Therapy
Polyamines, primarily spermidine and spermine, are small polycationic molecules essential for cell growth, signaling, and survival. Through electrostatic interactions with nucleic acids, lipids, and proteins, they regulate gene expression, organelle ...
Xianzun Tao, Tracey Nassuna, R. Grace Zhai   +2 more
doaj   +2 more sources

Erratum: DFMD: Fast and Effective DelPhiForce Steered Molecular Dynamics Approach to Model Ligand Approach Toward a Receptor: Application to Spermine Synthase Enzyme [PDF]

Frontiers in Molecular Biosciences, 2019
Frontiers Production Office
doaj   +2 more sources

Spermine synthase engages in macrophages M2 polarization to sabotage antitumor immunity in hepatocellular carcinoma. [PDF]

Cell Death Differ
Disturbances in tumor cell metabolism reshape the tumor microenvironment (TME) and impair antitumor immunity, but the implicit mechanisms remain elusive.
Sun Y, Zhou P, Qian J, Zeng Q, Wei G, Li Y, Liu Y, Lai Y, Zhan Y, Wu D, Fang Y.   +10 more
europepmc   +2 more sources

Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

Communications Biology, 2022
Sex-dependent metabolism of spermine alter trophoblast gene expression through acetyl-coA biosynthesis and histone acetylation, indicating that escape of spermine synthase from X-linked inactivation partially contributes to placental sex differences.
Irving L. M. H. Aye, Sungsam Gong, Giulia Avellino, Roberta Barbagallo, Francesca Gaccioli, Benjamin J. Jenkins, Albert Koulman, Andrew J. Murray, D. Stephen Charnock-Jones, Gordon C. S. Smith   +9 more
doaj   +1 more source

Putrescine supplementation shifts macrophage L-arginine metabolism related-genes reducing Leishmania amazonensis infection.

PLoS ONE, 2023
Leishmania is a protozoan that causes leishmaniasis, a neglected tropical disease with clinical manifestations classified as cutaneous, mucocutaneous, and visceral leishmaniasis.
Jonathan Miguel Zanatta, Stephanie Maia Acuña, Yan de Souza Angelo, Camilla de Almeida Bento, Jean Pierre Schatzman Peron, Beatriz Simonsen Stolf, Sandra Marcia Muxel   +6 more
doaj   +1 more source

Synergistic effect of carbon nanoparticles with mild salinity for improving chemical composition and antioxidant activities of radish sprouts

Frontiers in Plant Science, 2023
The demand for healthy foods with high functional value has progressively increased. Carbon nanoparticles (CNPs) have a promising application in agriculture including the enhancement of plant growth.
Riyadh F. Halawani, Hamada AbdElgawad, Fahed A. Aloufi, Mansour A. Balkhyour, Ahlem Zrig, Ahlem Zrig, Abdelrahim H.A. Hassan, Abdelrahim H.A. Hassan   +7 more
doaj   +1 more source

Specificity of mammalian spermidine synthase and spermine synthase [PDF]

Biochemical Journal, 1981
1. The specificity of rat prostatic spermidine synthase and spermine synthase with respect to the amine acceptor of the propylamine group was studied. 2. Spermidine synthase could use cadaverine (1,5-diaminopentane) instead of putrescine, but the Km for cadaverine was much greater and the rate with 1mM-cadaverine was only 10% of that with putrescine. 1,
A E, Pegg, K, Shuttleworth, H, Hibasami
openaire   +2 more sources