Spermine and thermospermine synthases emerged multiple times during eukaryote evolution. [PDF]
J Biol ChemThe polyamines spermine and thermospermine are differentially distributed throughout eukaryotic phyla. It is unlikely that they were present in the Last Eukaryotic Common Ancestor, thus their biosynthetic enzymes, spermine synthase (SpmSyn) and ...
Li B +4 more
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Aminopropyltransferases involved in polyamine biosynthesis localize preferentially in the nucleus of plant cells. [PDF]
PLoS ONE, 2012 Plant aminopropyltransferases consist of a group of enzymes that transfer aminopropyl groups derived from decarboxylated S-adenosyl-methionine (dcAdoMet or dcSAM) to propylamine acceptors to produce polyamines, ubiquitous metabolites with positive charge
Borja Belda-Palazón +8 more
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Association Between Plasma Diacetylspermine and Tumor Spermine Synthase With Outcome in Triple-Negative Breast Cancer. [PDF]
J Natl Cancer Inst, 2020 BACKGROUND MYC is an oncogenic driver of development and progression in triple-negative breast cancer (TNBC). Ornithine decarboxylase, the rate-limiting enzyme in polyamine metabolism, is a transcriptional target of MYC.
Fahrmann JF +17 more
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Overexpression of SAMDC1 gene in Arabidopsis thaliana increases expression of defense-related genes as well as resistance to Pseudomonas syringae and Hyaloperonospora arabidopsidis [PDF]
Frontiers in Plant Science, 2014 It has been previously described that elevation of endogenous spermine levels in Arabidopsis could be achieved by transgenic overexpression of S-Adenosylmethionine decarboxylase (SAMDC) or Spermine synthase (SPMS).
Francisco eMarco +2 more
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Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage. [PDF]
World J Gastrointest OncolBACKGROUND Colorectal cancer (CRC), the third most common cancer worldwide, has increasingly detrimental effects on human health. Radiotherapy resistance diminishes treatment efficacy. Studies suggest that spermine synthase (SMS) may serve as a potential
Guo YB, Wu YM, Lin ZZ.
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Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome. [PDF]
Nat Commun, 2018 The originally published version of this Article contained errors in Figure 1. In panel c, the grey shading denoting evolutionary conservation and the arrowheads indicating amino acids affected in Snyder-Robinson syndrome were displaced relative to the ...
Li C +15 more
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Journal of Plant Interactions, 2019 Spermine (SPM) was utilized to investigate its impact on the accumulation of sucrose synthase (SUS) and the role of SUS as a predictor of sink strength of rice under cyclic water stress.
Zulkarami Berahim +2 more
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Spermine synthase engages in macrophages M2 polarization to sabotage antitumor immunity in hepatocellular carcinoma. [PDF]
Cell Death DifferSun Y +10 more
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Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach. [PDF]
PLoS ONE, 2014 Snyder-Robinson Syndrome (SRS) is a rare mental retardation disorder which is caused by the malfunctioning of an enzyme, the spermine synthase (SMS), which functions as a homo-dimer.
Zhe Zhang +5 more
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Functional and Biochemical Characterization of Spermidine Synthase CauSpe3 from Candidozyma auris [PDF]
PathogensPolyamines, putrescine, spermidine and spermine, are essential polycationic metabolites present in all eukaryotic cells, where they regulate fundamental processes including nucleic acid stabilization, translation, and stress responses.
Jae-Yeon Choi +2 more
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