Enhancing human spermine synthase activity by engineered mutations. [PDF]
PLoS Computational Biology, 2013 Spermine synthase (SMS) is an enzyme which function is to convert spermidine into spermine. It was shown that gene defects resulting in amino acid changes of the wild type SMS cause Snyder-Robinson syndrome, which is a mild-to-moderate mental disability ...
Zhe Zhang +5 more
doaj +6 more sources
Spermine Synthase : A Potential Prognostic Marker for Lower-Grade Gliomas. [PDF]
J Korean Neurosurg SocObjective The objective of this study was to assess the relationship between spermine synthase (SMS) expression, tumor occurrence, and prognosis in lower-grade gliomas (LGGs).
Liu C +7 more
europepmc +4 more sources
Myosin Va and spermine synthase: partners in exosome transport. [PDF]
Biosci Rep, 2019 A recent paper in Bioscience Reports (BSR20182189) describes the discovery of an interaction between the motor protein myosin Va and the metabolic enzyme spermine synthase.
Timson DJ.
europepmc +4 more sources
Myosin Va interacts with the exosomal protein spermine synthase. [PDF]
Biosci Rep, 2019 Myosin Va (MyoVa) is an actin-based molecular motor that plays key roles in the final stages of secretory pathways, including neurotransmitter release.
Dolce LG +8 more
europepmc +5 more sources
Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase [PDF]
International Journal of Molecular Sciences, 2016 Missense mutations in spermine synthase (SpmSyn) protein have been shown to cause the Snyder-Robinson syndrome (SRS). Depending on the location within the structure of SpmSyn and type of amino acid substitution, different mechanisms resulting in SRS were
Yunhui Peng +2 more
exaly +3 more sources
The RET inhibitor pralsetinib suppresses TMZ-resistant glioma growth by regulating spermine production [PDF]
Frontiers in PharmacologyObjectiveGlioma is the most common malignant tumor of the central nervous system and is characterized by altered cellular metabolism. Although temozolomide (TMZ)-based adjuvant treatment has improved overall patient survival, clinical outcomes remain ...
Lingyun Ma +11 more
doaj +3 more sources
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer [PDF]
Nature CommunicationsWhile dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients
Hanshen Yang +21 more
doaj +3 more sources
Long-range effect of a single mutation in spermine synthase
Journal of Theoretical and Computational Chemistry, 2018 Spermine synthase (SpmSyn) is an enzyme critical for maintaining the balance of spermine/spermidine in the cell. The amino acid sequence of SpmSyn is highly conserved among the species.
Yunhui Peng, Ekaterina Michonova
exaly +3 more sources
Spermine synthase (SMS) serves as a prognostic biomarker in head and neck squamous cell carcinoma: a bioinformatics analysis. [PDF]
Ann Transl Med, 2022 Background Head and neck squamous cell carcinoma (HNSC) is an aggressive type of cancer that lacks early detection, and therefore, has a low 5-year survival rate.
Pan X, Xue L, Sun Y.
europepmc +2 more sources
Novel Hemizygous Missense Variant of Spermine Synthase (SMS) Gene Causes Snyder-Robinson Syndrome in a Four-Year-Old Boy. [PDF]
Mol Syndromol, 2021 Snyder-Robinson syndrome (SRS) is an extremely rare X-linked intellectual disability syndrome (MRXSSR; MIM #309583). The main clinical features of SRS include psychomotor delay, hypotonia, and asthenic-type body habitus – reduced body weight and bone ...
Mouskou S +10 more
europepmc +2 more sources