Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase [PDF]
International Journal of Molecular SciencesDespite the well-known relevance of polyamines to many forms of life, little is known about how polyamines regulate osteogenesis and skeletal homeostasis.
Tracy Murray Stewart +2 more
exaly +4 more sources
Myosin Va interacts with the exosomal protein spermine synthase. [PDF]
Biosci Rep, 2019 Abstract Myosin Va (MyoVa) is an actin-based molecular motor that plays key roles in the final stages of secretory pathways, including neurotransmitter release. Several studies have addressed how MyoVa coordinates the trafficking of secretory vesicles, but why this molecular motor is found in exosomes is still unclear.
Dolce LG +8 more
europepmc +4 more sources
Age-Dependent Redistribution of the Life-Important Enzyme in the Retina: Adult Müller Glial Cells’ Endfeet Lack Spermine Synthase Expression [PDF]
BiomoleculesPolyamine (PA) spermine (SPM) (i) plays an essential role in the function of neurons, while (ii) accumulating predominantly in glial cells by an unknown mechanism.
Astrid Zayas-Santiago +8 more
doaj +2 more sources
Spermine Synthase : A Potential Prognostic Marker for Lower-Grade Gliomas. [PDF]
J Korean Neurosurg SocObjective : The objective of this study was to assess the relationship between spermine synthase (SMS) expression, tumor occurrence, and prognosis in lower-grade gliomas (LGGs).Methods : A total of 523 LGG patients and 1152 normal brain tissues were included as controls.
Liu C +7 more
europepmc +3 more sources
Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine [PDF]
FEBS Letters, 2007 Polyamines are involved in many fundamental cellular processes. Common polyamines are putrescine, spermidine and spermine. Spermine is synthesized by transfer of an aminopropyl residue derived from decarboxylated S‐adenosylmethionine to spermidine. Thermospermine is an isomer of spermine and assumed to be synthesized by an analogous mechanism. However,
Knott, Jürgen M. +2 more
openaire +4 more sources
The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies. [PDF]
Adv Sci (Weinh)This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Xiang G +5 more
europepmc +2 more sources
Exogenous Melatonin Enhances the Cold Tolerance of Harvested Peach (Prunus persica Batsch) Fruit by Elevating SAMDC and Decreasing ACC Synthase Activities [PDF]
PlantsExogenous melatonin can alleviate cold injury in post-harvested fruit during fruit refrigeration. The mechanism of melatonin-mediated cold tolerance is increasingly being focused on in studies.
Hongyang Du +5 more
doaj +2 more sources
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome [PDF]
Nature Communications, 2017 Mutations in spermine synthase lead to Snyder-Robinson syndrome, a form of intellectual disability syndrome. Here the authors develop a Drosophila model of this disease, and show that lysosomal dysfunction and oxidative stress contribute to the ...
Chong Li +15 more
doaj +2 more sources
Cell Mol Life Sci, 2010 Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function.
Pegg AE, Michael AJ.
europepmc +4 more sources
The impact of spermine synthase (SMS) mutations on brain morphology [PDF]
Neurogenetics, 2009 Snyder-Robinson syndrome (SRS) is a form of X-linked mental retardation resulting from mutations in spermine synthase (SMS), which impact neurodevelopment and cognitive outcome. We obtained cerebral, cerebellum, hippocampus, and red nucleus volumes from two males with SRS and 24 age- and gender-matched typically developing controls using volumetric ...
Roger Stevenson +2 more
exaly +3 more sources