Results 31 to 40 of about 176,600 (181)
Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene [PDF]
Human Molecular Genetics, 1998 Two mouse mutations gyro (Gy) and hypophosphatemia (Hyp) are mouse models for X-linked hypophosphatemic rickets and have been shown to be deleted for the 5' and 3' end of the mouse homolog of PHEX (phosphate regulating gene with homologies to endopeptidases on the X chromosome; formerly called PEX), respectively.
B, Lorenz +9 more
openaire +2 more sources
Studies of inhibition of rat spermidine synthase and spermine synthase [PDF]
Biochemical Journal, 1980 1. S-Adenosyl-l-methionine, S-adenosyl-l-homocysteine, 5′-methylthioadenosine and a number of analogues having changes in the base, sugar or amino acid portions of the molecule were tested as potential inhibitors of spermidine synthase and spermine synthase from rat ventral prostate. 2. S-Adenosyl-l-methionine was inhibitory to these reactions, as were
H, Hibasami +4 more
openaire +2 more sources
Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase [PDF]
International Journal of Molecular Sciences, 2016 Emil Alexov +2 more
exaly +2 more sources
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome
EMBO Molecular Medicine, 2023 Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and
Tracy Murray Stewart +8 more
doaj +1 more source
Aminopropyltransferases involved in polyamine biosynthesis localize preferentially in the nucleus of plant cells. [PDF]
PLoS ONE, 2012 Plant aminopropyltransferases consist of a group of enzymes that transfer aminopropyl groups derived from decarboxylated S-adenosyl-methionine (dcAdoMet or dcSAM) to propylamine acceptors to produce polyamines, ubiquitous metabolites with positive charge
Borja Belda-Palazón +8 more
doaj +1 more source
Fluorinated analogues of spermidine as substrates of spermine synthase [PDF]
European Journal of Biochemistry, 1988 A series of mono‐and geminal difluorinated analogues of spermidine (4‐azaoctane‐1, 8‐diamine) have been tested as potential substrates of partially purified rat hepatoma (HTC) cell or pure bovine spleen spermine synthase (EC 2.5.1.22).Substitution of the hydrogen atoms of the methylene group at position 7 by one or two fluorine atoms decreases 8‐fold ...
J G, Baillon +4 more
openaire +2 more sources
In Silico Investigation of Mutability of Spermine Synthase [PDF]
Biophysical Journal, 2011 Spermine Synthase (SMS) is an enzyme which controls spermidine/spermine concentrations, both of which are polyamines playing an important role for cell development. Recently we have investigated the effect of missense mutations (G56S, V132G and I150T) known to cause Synder-Robinson Syndrome (SRS) on SMS stability and dynamics.
Zhang, Zhe +2 more
openaire +1 more source
Characterization of transgenic mice with widespread overexpression of spermine synthase [PDF]
Biochemical Journal, 2004 A widespread increase in SpmS (spermine synthase) activity has been produced in transgenic mice using a construct in which the human SpmS cDNA was placed under the control of a composite CMV-IE (cytomegalovirus immediate early gene) enhancer–chicken β-actin promoter. Four separate founder CAG/SpmS mice were studied.
Yoshihiko, Ikeguchi +7 more
openaire +2 more sources
, 2022 Toward the design of new proline-rich peptidomimetics, a short peptide segment, present in several proline-rich antimicrobial peptides (AMPs), was selected.
Saman Habib (41045) +7 more
core +2 more sources
Frontiers in Plant Science, 2014 It has been previously described that elevation of endogenous spermine levels in Arabidopsis could be achieved by transgenic overexpression of S-Adenosylmethionine decarboxylase (SAMDC) or Spermine synthase (SPMS).
Francisco eMarco +2 more
doaj +1 more source