The Role of Spermidine Synthase (SpdS) and Spermine Synthase (Sms) in Regulating Triglyceride Storage in Drosophila [PDF]
Medical Sciences, 2021 Polyamines are small organic cations that are important for several biological processes such as cell proliferation, cell cycle progression, and apoptosis.
Tahj S. Morales +5 more
doaj +6 more sources
Spermine accumulation via spermine synthase promotes tumor cell proliferation in head and neck squamous cell carcinoma [PDF]
BMC CancerBackground Head and neck squamous cell carcinoma (HNSCC) is among the most aggressive malignancies, underscoring the need for early diagnosis to improve patient outcomes.
Xi Chen +9 more
doaj +5 more sources
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation [PDF]
Cell Death and DiseasePrecise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy blockage in ...
Xianzun Tao +7 more
doaj +5 more sources
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression [PDF]
Nature Communications, 2020 Polyamine metabolism is frequently dysregulated in cancers. Here, the authors show that a polyamine biosynthetic enzyme, spermine synthase, is overexpressed in colorectal cancers and cooperates with MYC to prevent cancer cell apoptosis by repression of ...
Yubin Guo +13 more
doaj +4 more sources
METTL3-IGF2BP3-axis mediates the proliferation and migration of pancreatic cancer by regulating spermine synthase m6A modification [PDF]
Frontiers in Oncology, 2022 Spermine synthase (SMS) is an enzyme participating in polyamine synthesis; however, its function and role in pancreatic cancer remains elusive. Here we report that SMS is upregulated in pancreatic cancer and predicts a worse overall survival and ...
Zhenyun Guo +17 more
doaj +3 more sources
Age-Dependent Redistribution of the Life-Important Enzyme in the Retina: Adult Müller Glial Cells’ Endfeet Lack Spermine Synthase Expression [PDF]
BiomoleculesPolyamine (PA) spermine (SPM) (i) plays an essential role in the function of neurons, while (ii) accumulating predominantly in glial cells by an unknown mechanism.
Astrid Zayas-Santiago +8 more
doaj +3 more sources
Whole-exome sequencing identifies a novel mutation in spermine synthase gene (SMS) associated with Snyder-Robinson Syndrome [PDF]
BMC Medical Genetics, 2020 Background Loss of function mutations in the spermine synthase gene (SMS) have been reported to cause a rare X-linked intellectual disability known as Snyder-Robinson Syndrome (SRS).
Talal J. Qazi +8 more
doaj +3 more sources
Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase [PDF]
International Journal of Molecular SciencesDespite the well-known relevance of polyamines to many forms of life, little is known about how polyamines regulate osteogenesis and skeletal homeostasis.
Bryan Le +2 more
exaly +3 more sources
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome [PDF]
Nature Communications, 2017 Mutations in spermine synthase lead to Snyder-Robinson syndrome, a form of intellectual disability syndrome. Here the authors develop a Drosophila model of this disease, and show that lysosomal dysfunction and oxidative stress contribute to the ...
Chong Li +15 more
doaj +3 more sources
DFMD: Fast and Effective DelPhiForce Steered Molecular Dynamics Approach to Model Ligand Approach Toward a Receptor: Application to Spermine Synthase Enzyme [PDF]
Frontiers in Molecular Biosciences, 2019 Here we report a novel approach, the DelPhiForce Molecular Dynamics (DFMD) method, for steered molecular dynamics simulations to model receptor-ligand association involving charged species.
Yunhui Peng +5 more
doaj +3 more sources