Results 1 to 10 of about 176,600 (181)

Spermine accumulation via spermine synthase promotes tumor cell proliferation in head and neck squamous cell carcinoma [PDF]

BMC Cancer
Background Head and neck squamous cell carcinoma (HNSCC) is among the most aggressive malignancies, underscoring the need for early diagnosis to improve patient outcomes.
Xi Chen, Fei Song, Peng Xiao, Yisong Yao, Dongxian Li, Yuhui Fang, Shijun Lv, Yakui Mou, Yumei Li, Xicheng Song   +9 more
doaj   +5 more sources

Enhancing human spermine synthase activity by engineered mutations. [PDF]

PLoS Computational Biology, 2013
Spermine synthase (SMS) is an enzyme which function is to convert spermidine into spermine. It was shown that gene defects resulting in amino acid changes of the wild type SMS cause Snyder-Robinson syndrome, which is a mild-to-moderate mental disability ...
Zhe Zhang, Yueli Zheng, Margo Petukh, Anthony Pegg, Yoshihiko Ikeguchi, Emil Alexov   +5 more
doaj   +10 more sources

Reduction of spermine synthase enhances autophagy to suppress Tau accumulation [PDF]

Cell Death and Disease
Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy blockage in ...
Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R. Foley, Ashley Nwafor, Tracy Murray Stewart, Robert A. Casero, R. Grace Zhai   +7 more
doaj   +5 more sources

The Role of Spermidine Synthase (SpdS) and Spermine Synthase (Sms) in Regulating Triglyceride Storage in Drosophila [PDF]

Medical Sciences, 2021
Polyamines are small organic cations that are important for several biological processes such as cell proliferation, cell cycle progression, and apoptosis.
Tahj S. Morales, Erik C. Avis, Elise K. Paskowski, Hamza Shabar, Shannon L. Nowotarski, Justin R. DiAngelo   +5 more
doaj   +6 more sources

Myosin Va and spermine synthase: partners in exosome transport. [PDF]

Biosci Rep, 2019
Abstract A recent paper in Bioscience Reports (BSR20182189) describes the discovery of an interaction between the motor protein myosin Va and the metabolic enzyme spermine synthase. Myosin Va is a molecular motor which plays a key role in vesicle transport.
Timson DJ.
europepmc   +5 more sources

DFMD: Fast and Effective DelPhiForce Steered Molecular Dynamics Approach to Model Ligand Approach Toward a Receptor: Application to Spermine Synthase Enzyme [PDF]

Frontiers in Molecular Biosciences, 2019
Here we report a novel approach, the DelPhiForce Molecular Dynamics (DFMD) method, for steered molecular dynamics simulations to model receptor-ligand association involving charged species.
Emil Alexov, Yunhui Peng, Weiguo Cao
exaly   +4 more sources

METTL3-IGF2BP3-axis mediates the proliferation and migration of pancreatic cancer by regulating spermine synthase m6A modification [PDF]

Frontiers in Oncology, 2022
Spermine synthase (SMS) is an enzyme participating in polyamine synthesis; however, its function and role in pancreatic cancer remains elusive. Here we report that SMS is upregulated in pancreatic cancer and predicts a worse overall survival and ...
Zhenyun Guo, Zhenyun Guo, Xiang Zhang, Xiang Zhang, Chengjie Lin, Chengjie Lin, Yue Huang, Yue Huang, Yun Zhong, Yun Zhong, Hailing Guo, Hailing Guo, Zhou Zheng, Zhou Zheng, Shangeng Weng, Shangeng Weng, Shangeng Weng, Shangeng Weng   +17 more
doaj   +2 more sources

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression [PDF]

Nature Communications, 2020
Polyamine metabolism is frequently dysregulated in cancers. Here, the authors show that a polyamine biosynthetic enzyme, spermine synthase, is overexpressed in colorectal cancers and cooperates with MYC to prevent cancer cell apoptosis by repression of ...
Yubin Guo, Qing Ye, Pan Deng, Yanan Cao, Daheng He, Zhaohe Zhou, Chi Wang, Yekaterina Y. Zaytseva, Charles E. Schwartz, Eun Y. Lee, B. Mark Evers, Andrew J. Morris, Side Liu, Qing-Bai She   +13 more
doaj   +2 more sources

Whole-exome sequencing identifies a novel mutation in spermine synthase gene (SMS) associated with Snyder-Robinson Syndrome [PDF]

BMC Medical Genetics, 2020
Background Loss of function mutations in the spermine synthase gene (SMS) have been reported to cause a rare X-linked intellectual disability known as Snyder-Robinson Syndrome (SRS).
Talal J. Qazi, Qiao Wu, Ailikemu Aierken, Daru Lu, Ihtisham Bukhari, Hafiz M. J. Hussain, Jingmin Yang, Asif Mir, Hong Qing   +8 more
doaj   +2 more sources

Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers [PDF]

International Journal of Neuropsychopharmacology, 2010
Alterations in the levels of spermine synthase (SMS) and spermine oxidase (SMOX), two enzymes involved in polyamine metabolism, have previously been observed in brains of suicide completers. To characterize the roles played by genetic and epigenetic factors in determining expression levels of these genes, as well as to identify potential mechanisms by ...
Laura Fiori, Gustavo Turecki
exaly   +3 more sources