Results 11 to 20 of about 1,019 (188)

Spesolimab for treatment of generalized pustular psoriasis of pregnancy

Pregnancy
Introduction Generalized pustular psoriasis (GPP) is a severe, desquamating skin disorder associated with pregnancy that presents as fever, fatigue, malaise and sterile pustules.
Jason Bunn, Christine Henricks, Aaminah Azhar, Cristina Thomas, Edward Hadeler, Alexandra Smith, R. Nicholas Burns, Jarad Levin, Marvin Williams, Hugh Nadeau   +9 more
doaj   +3 more sources

Successful Treatment of Spesolimab in a Haemodialysis Patient With Acutely Flaring Generalised Pustular Psoriasis

JEADV Clinical Practice
The efficacy and safety of biologics in patients with psoriasis and end‐stage renal disease is rarely reported. Here, we report a case of generalised pustular psoriasis (GPP) in a patient under haemodialysis successfully treated with spesolimab, with a ...
Yasuyuki Fujita, Sota Itamoto, Akihiro Orita, Kunihiro Kawashima, Satoko Shimizu   +4 more
doaj   +3 more sources

Biologics and Small-Molecule Therapies in Netherton Syndrome: A Comprehensive Review. [PDF]

J Dermatol
Netherton syndrome (NS) is a rare congenital ichthyosis caused by loss-of-function mutations in the SPINK5 gene, leading to defective expression of the serine protease inhibitor LEKTI.
Morizane S, Mukai T, Sunagawa K, Hasui KI, Morita A, Nomura H, Ouchida M.   +6 more
europepmc   +4 more sources

Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study [PDF]

Dermatology and Therapy, 2023
Introduction We evaluated the anti-interleukin-36 receptor antibody spesolimab in patients with moderate-to-severe palmoplantar pustulosis (PPP). Methods This phase IIb trial comprised a loading dose period to week (W) 4, then maintenance dosing to W52 ...
A. David Burden, Robert Bissonnette, Alexander A. Navarini, Masamoto Murakami, Akimichi Morita, Thomas Haeufel, Binqi Ye, Frank Baehner, Tadashi Terui   +8 more
doaj   +2 more sources

Successful treatment of recalcitrant generalized pustular psoriasis of pregnancy with spesolimab

Journal of Dermatological Treatment
Generalized pustular psoriasis (GPP) in pregnancy can lead to severe complications for both mother and fetus. The treatment of this disease is challenging, especially in recalcitrant and severe cases. Until present, there are no evidence-based guidelines
Chenxin Yang, Yang Wang, Ruoyu Li, Ping Tu, Ruojun Wang   +4 more
doaj   +4 more sources

Lymphomatoid Papulosis Following Spesolimab Treatment for Generalised Pustular Psoriasis. [PDF]

Australas J Dermatol
Australasian Journal of Dermatology, Volume 66, Issue 5, Page e314-e315, August 2025.
Namba M, Matsumoto M, Saito N, Kimura A, Sagara C, Rokunohe D, Akasaka E.   +6 more
europepmc   +4 more sources

Trial of spesolimab for generalized pustular psoriasis. [PDF]

New England Journal of Medicine, 2021
BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 signaling is involved in the pathogenesis of this disorder.
Anadkat, Milan J., Bachelez, Hervé, Burden, A. David, Choon, Siew-Eng, Effisayil 1 Trial Investigators, Hall, David, Hua, Hairui, Lebwohl, Mark G., Marrakchi, Slaheddine, Morita, Akimichi, Navarini, Alexander A., Rajeswari, Sushmita, Tetzlaff, Kay, Thoma, Christian, Tsai, Tsen-Fang, Turki, Hamida, Vulcu, Sebastian D., Xu, Jinhua, Zheng, Min   +18 more
core   +6 more sources

Proof-of-concept study exploring the effect of spesolimab in patients with moderate-to-severe hidradenitis suppurativa:A randomized double-blind placebo-controlled clinical trial [PDF]

British Journal of Dermatology
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a considerable disease burden. Existing treatment options are limited and often suboptimal; a high unmet need exists for effective targeted therapies.
Alavi, Afsaneh, Frew, John W., Gao, Heli, Hernandez Daly, Ana C., Ivanoff, Nathalie B., Kimball, Alexa B., Krueger, James G., Mukhopadhyay, Sutirtha, Prens, Errol P., Ranganathan, Usha, Zouboulis, Christos C.   +10 more
core   +3 more sources

The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab [PDF]

Frontiers in Immunology, 2023
Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder characterized by recurrent flares associated with skin erythema, desquamation, and widespread superficial sterile pustules, which may be severe (“lakes of pus”). Systemic
Jason E. Hawkes, Sudha Visvanathan, James G. Krueger   +2 more
doaj   +3 more sources

Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares. [PDF]

J Clin Invest
People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares.
Krueger JG, Sarkar MK, Lebwohl MG, Morita A, Gordon K, Bogle R, Cole C, Coon A, Langley RG, Warren RB, Mostaghimi A, Strober B, Burden AD, Zheng M, Mangold AR, Anadkat MJ, Barker JN, Merola JF, Tsoi LC, Tang M, Becker K, Delic D, Thoma C, Gudjonsson JE.   +23 more
europepmc   +2 more sources