Results 21 to 30 of about 1,019 (188)

Spesolimab for acute-flare generalized pustular psoriasis with severe erythema and plaques: A case report. [PDF]

Medicine (Baltimore)
Rationale: Psoriasis is a prevalent, chronic papulosquamous skin disease, with generalized pustular psoriasis (GPP) representing a severe variant. Dysregulation of the IL-36 signaling pathway plays a crucial role in GPP, making biologics targeting this ...
Yu K, Cao C, Wu X.
europepmc   +2 more sources

Spesolimab for the treatment of Generalized Pustular Psoriasis [PDF]

Drugs, 2023
Generalized pustular psoriasis (GPP) is a rare but severe skin inflammatory disorder characterized by the eruption of widespread sterile neutrophilic pustules, often accompanied by systemic inflammation. Given its life-threatening potential, GPP requires prompt accurate diagnosis and effective treatment, but its rarity and relapsing-remitting nature ...
Ana Margarida Machado Curval
core   +6 more sources

Spesolimab for generalised pustular psoriasis. [PDF]

Aust Prescr
europepmc   +4 more sources

Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare [PDF]

BMJ Open, 2021
Introduction Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening disease characterised by recurrent flares of widespread neutrophilic aseptic skin pustular eruption. Despite the availability of approved biologics for GPP in Japan,
Hamida Turki, Akimichi Morita, Min Zheng, Tsen-Fang Tsai, Siew Eng Choon, Mark G Lebwohl, Slaheddine Marrakchi, A David Burden, Alexander A Navarini, Jinhua Xu, Sushmita Rajeswari, Hongjie Deng, Kay Tetzlaff, Christian Thoma, Hervé Bachelez   +14 more
doaj   +3 more sources

Successful treatment of etanercept- and adalimumab-resistant pyoderma gangrenosum with spesolimab, moderate-dose corticosteroids, and minocycline

Journal of Dermatological Treatment
Purpose Pyoderma gangrenosum (PG) is a rare, neutrophilic dermatosis characterized by rapidly developing, painful ulcers. This study explores the potential of spesolimab, an anti-IL-36R antibody, as a therapeutic option for refractory PG.Materials and ...
Hanlin Zhang, Chao Wu, Hongzhong Jin
doaj   +2 more sources

Effectiveness and Safety of Spesolimab in Patients with Generalized Pustular Psoriasis: A Single-centre Retrospective Study [PDF]

Acta Dermato-Venereologica
Yoshiki Okada, Masahiro Kamata, Kotaro Hayashi, Kazumitsu Sugiura, Yayoi Tada   +4 more
doaj   +3 more sources

IL-36 signaling as a drug target in Crohn's disease patients with IL36RN mutations. [PDF]

EMBO Mol Med
The IL-36 signaling pathway has recently been identified as a key regulator of intestinal homeostasis and inflammation. However, the role of mutations in the IL-36R signaling pathway in the pathogenesis of inflammatory bowel disease remains unclear.
Hecker J, Plattner C, Cancino CA, Löscher BS, Saurenbach J, Letizia M, Rieder D, TRR241 IBDome Consortium, Freise I, Koop K, Neufert C, Kunkel D, Al Khatim Z, Schaafs LA, Schütz A, Becker C, Atreya R, Trajanoski Z, Franke A, Sonnenberg E, Hegazy AN, Siegmund B, Weidinger C.   +22 more
europepmc   +6 more sources

Real-world efficacy of spesolimab in treating generalized pustular psoriasis flares: A case series review

Dermatologica Sinica
This case series review examines the efficacy of spesolimab in managing generalized pustular psoriasis (GPP) flares, including those exacerbated by coronavirus disease 2019 (COVID-19) vaccination.
Chun-Bing Chen, Chun-Wei Lu, Chuang-Wei Wang, Wen-Hung Chung   +3 more
doaj   +2 more sources

Expanding the therapeutic horizons of spesolimab: a review of off-label applications for inflammatory skin diseases

Journal of Dermatological Treatment
Purpose This review aims to outline the crucial role of IL-36 signaling in inflammatory skin diseases and summarize the therapeutic potential of spesolimab.
Hanlin Zhang, Jia Zhou, Keyun Tang, Xinyi Zhang, Hongzhong Jin   +4 more
doaj   +2 more sources

Spesolimab for a child with generalized pustular psoriasis accompanied epilepsy and hyperactivity

Journal of Dermatological Treatment
Objectives To evaluate the therapeutic efficacy and safety of spesolimab in pediatric GPP treatment.Methods We report a 10-year-old male pediatric patient with refractory Generalized Pustular Psoriasis (GPP), comorbid epilepsy, hyperactivity ...
Yudan Wang, Jie Qin, Li Peng, Linli He, Beichen Yang, Mei Yang, Yanyan Feng   +6 more
doaj   +2 more sources