Results 61 to 70 of about 1,019 (188)

Crusted Scabies in a Patient being Treated with Spesolimab for Generalized Pustular Psoriasis [PDF]

Acta Dermato-Venereologica
Hanna Schratter, Thomas Graier, Franz Legat, Rainer Hofmann-Wellenhof, Peter Wolf   +4 more
doaj   +2 more sources

Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia [PDF]

, 2023
Generalized Pustular psoriasis (GPP), a rare and potentially life-threatening auto-inflammatory disease, is associated with IL36RN mutations. Here, we analyse the prevalence of IL36RN mutations in our multi-ethnic GPP cohort and assess differences in the
Barker, Jonathan N., Capon, Francesca, Choon, Siew Eng, Lim, Yee Ting, Nanu, Nalini M., Tok, Peter Seah Keng, Wong, Kit Wan   +6 more
core   +1 more source

First experiences in real clinical practice treating a patient with generalised pustular psoriasis with Spesolimab

JEADV Clinical Practice, 2023
Generalised pustular psoriasis is a rare, unpredictable, and sometimes severe subtype of psoriasis whose treatment is hampered by a lack of consensus and standardised therapeutic guidelines.
Aurora Fernández‐Galván, Esteban Daudén, Beatriz Butron‐Bris, Mireia Seguí‐Olmedilla, Ana Miguélez, Javier Fraga, Pedro Rodríguez Jiménez, Mar Llamas‐Velasco   +7 more
doaj   +1 more source

Bilateral Idiopathic Pyoderma Gangrenosum: A Case Report of an Atypical Presentation. [PDF]

Clin Case Rep
ABSTRACT Pyoderma gangrenosum (PG) is a rare non‐infectious neutrophilic dermatosis which is characterized by a rapidly progressive, painful ulcer. Bilateral manifestation of PG is exceptionally rare and can easily be misdiagnosed as infection or vascular ulceration, delaying proper treatment.
Magar ST, Sitaula D, Rijal S, Paudel V, Kayastha BMM.   +4 more
europepmc   +2 more sources

Efficacy of spesolimab for the treatment of generalized pustular psoriasis flares across pre-specified patient subgroups in the Effisayil 1 study [PDF]

, 2023
Effisayil 1 was a multicentre, randomized, double‐blind, placebo‐controlled study of the anti‐interleukin (IL)‐36 receptor monoclonal antibody, spesolimab, in patients presenting with a generalized pustular psoriasis (GPP) flare.
Burden, A.D., Choon, S. E., Hu, N., Okubo, Y., Quaresma, M., Thaçi, D., Thoma, C., van de Kerkhof, P., Zheng, M.   +8 more
core   +1 more source

Safety and tolerability of spesolimab in patients with ulcerative colitis

Expert Opinion on Drug Safety, 2022
Interleukin (IL)-36 signaling has been shown to be increased in ulcerative colitis (UC). Spesolimab, a novel humanized monoclonal antibody, targets the IL-36 pathway.We report safety, immunogenicity, and efficacy data of intravenous (IV) spesolimab in UC. Study 1: phase II, randomized, placebo-controlled trial (300 mg single dose; 450 mg every 4 weeks [
Marc Ferrante, Peter M Irving, Christian P Selinger, Geert D’Haens, Tanja Kuehbacher, Ursula Seidler, Savion Gropper, Thomas Haeufel, Sebastiano Forgia, Silvio Danese, Jochen Klaus, Brian G. Feagan   +11 more
openaire   +3 more sources

Pustular psoriasis and the potential therapeutic usage of an IL-36 receptor monoclonal antibody [PDF]

, 2023
Pustular psoriasis is an uncommon subtype of psoriasis that dramatically affects the quality of life of affected patients. Pustules can emerge anywhere along the trunk, limbs, soles, palms, and fingers, which debilitates the functionality of these ...
Habal, Shafik, Miclat, Jeannel T
core   +1 more source

Characteristics and management of generalized pustular psoriasis (GPP): Experience from the Central and Eastern Europe (CEE) GPP Expert Network [PDF]

Background: Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by widespread eruption of sterile pustules with or without systemic symptoms.ObjectivesThis study aimed to describe the demographics of patients with GPP ...
Ceovic, R, Conrad, C, Falkensteiner, K, Graier, T, Kołt‐Kamińska, M, Marovt, M, Mateeva, V, Maul, J ‐T, Navarini, A A, Nicolescu, A C, Pavlovsky, L, Ratzinger, G, Reich, A, Sanzharovskaya, M, Szegedi, A, Wolf, P   +15 more
core   +4 more sources

Clinical Characteristics of Patients with Pustular Psoriasis: A Single-Center Retrospective Observational Study [PDF]

, 2022
Clinical and epidemiologic data on pustular psoriasis are scarce. To investigate the phenotypes of pustular psoriasis and the patients’ characteristics observed in a real-life retrospective observational study.
Bellinato, Francesco, Girolomoni, Giampiero, Gisondi, Paolo   +2 more
core   +1 more source

Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasis [PDF]

Journal of Allergy and Clinical Immunology, 2022
The IL-36 pathway plays a key role in the pathogenesis of generalized pustular psoriasis (GPP). In a proof-of-concept clinical trial, treatment with spesolimab, an anti-IL-36 receptor antibody, resulted in rapid skin and pustular clearance in patients presenting with GPP flares.We sought to compare the molecular profiles of lesional and nonlesional ...
Patrick Baum, Sudha Visvanathan, Sandra Garcet, Janine Roy, Ramona Schmid, Sebastian Bossert, Benjamin Lang, Hervé Bachelez, Robert Bissonnette, Christian Thoma, James G. Krueger   +10 more
openaire   +2 more sources