Results 11 to 20 of about 117,630 (212)

Heterotypic 3D Model of Breast Cancer Based on Tumor, Stromal and Endothelial Cells: Cytokines Interaction in the Tumor Microenvironment [PDF]

Cells
The recreation of the tumor microenvironment remains a significant challenge in the development of experimental cancer models. The present study constitutes an investigation into the interconnection between tumor, endothelial and stromal cells in ...
Anastasia Leonteva, Alina Kazakova, Ekaterina Berezutskaya, Anna Ilyina, David Sergeevichev, Sergey Vladimirov, Maria Bogachek, Igor Vakhrushev, Pavel Makarevich, Vladimir Richter, Anna Nushtaeva   +10 more
doaj   +2 more sources

O2-sensitive microcavity arrays: A new platform for oxygen measurements in 3D cell cultures

Frontiers in Bioengineering and Biotechnology, 2023
Oxygen concentration plays a crucial role in (3D) cell culture. However, the oxygen content in vitro is usually not comparable to the in vivo situation, which is partly due to the fact that most experiments are performed under ambient atmosphere ...
Christoph Grün, Jana Pfeifer, Gregor Liebsch, Eric Gottwald   +3 more
doaj   +1 more source

Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates

Cancers, 2023
Simple Summary Cancer is a global public health issue. The development and use of in vitro cellular models with pre-clinical animal models are essential to elucidate the complex biology of cancer and test new diagnostic and therapeutic options.
P. Nayak, Valeria Bentivoglio, M. Varani, Alberto Signore   +3 more
semanticscholar   +1 more source

Spheroid Engineering in Microfluidic Devices

ACS Omega, 2023
Two-dimensional (2D) cell culture techniques are commonly employed to investigate biophysical and biochemical cellular responses. However, these culture methods, having monolayer cells, lack cell–cell and cell–extracellular matrix interactions, mimicking
Atakan Tevlek, Seren Keçili, Ozge S Ozcelik, H. Kulah, H. Tekin   +4 more
semanticscholar   +1 more source

Engineered Biomaterials to Guide Spheroid Formation, Function, and Fabrication into 3D Tissue Constructs.

Acta Biomaterialia, 2022
Cellular spheroids are aggregates of cells that are being explored to address fundamental biological questions and as building blocks for engineered tissues.
Nikolas Di Caprio, J. Burdick
semanticscholar   +1 more source

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Nature Communications, 2020
Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation.
P. Dinh, Dipti Paudel, H. Brochu, Kristen D. Popowski, M. Gracieux, Jhon Cores, Jhon Cores, Ke Huang, M. T. Hensley, Erin Harrell, A. Vandergriff, Arianna George, R. Barrio, Shiqi Hu, Shiqi Hu, Tyler A. Allen, K. Blackburn, T. Caranasos, Xinxia Peng, L. Schnabel, K. Adler, L. Lobo, Michael B Goshe, Ke Cheng, Ke Cheng   +24 more
semanticscholar   +1 more source

Breast Cancer MCF-7 Cell Spheroid Culture for Drug Discovery and Development

Journal of Cancer Therapy, 2022
In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found in solid tumors. 3D spheroid culture methods recreate more physiologically relevant microenvironments for cells. Therefore, these models are more appropriate
Guangping Chen, William C Liu, B. Yan
semanticscholar   +1 more source

Advanced spheroidal degeneration [PDF]

Digital Journal of Ophthalmology, 2019
Spheroidal degeneration, involving the cornea and/or the conjunctiva, is characterized by amber-colored homogeneous, translucent spherules in the corneal stroma, Bowman’s membrane, and subepithelium. The condition has a higher prevalence in areas with extreme temperatures, low humidity, high wind, and presence of sand.
Abdelrahman M, Elhusseiny, Reem H, El Sheikh, Emery, Jamerson, Islam Y, Swaify, Ahmed B, Araissi, Abdelaziz A, Saad   +5 more
openaire   +2 more sources

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels

Nature Communications, 2020
Cellular models are needed to study human development and disease in vitro, and to screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of functional tissue models with requisite cell densities and heterogeneity to ...
Andrew C. Daly, M. D. Davidson, J. Burdick   +2 more
semanticscholar   +1 more source

Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling

npj Regenerative Medicine, 2022
Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to address defects arising from trauma, inefficient wound repair, or congenital malformation.
Katherine H Griffin, Shierly W. Fok, J. Kent Leach   +2 more
semanticscholar   +1 more source