Results 41 to 50 of about 67,710 (307)

Cortical spheroid on vascular network.

, 2023
(A) 3D and 2D confocal images of spheroid on vascular network (Red (CD31) is microvessel and green (beta III tubulin) is cortical spheroid), (B) represented images of cortical spheroid growth and spreading on vascular network and quantitative data for ...
Teal Russell (5844170), Chiwan Chiang (17240723), Yeoheung Yun (1667800), Qassim Dirar (9421685), Yan Li (23143), Daniel T. Laskowitz (7841270)   +5 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Additional co-culture spheroid images.

, 2022
a) Replicates of BxPC3 (green) and BxGR-360C (red) co-culture spheroids (3:1 ratio) 4 and 24 hours after seeding. 2000 total cells per spheroid. Scale bar 100 μm. b) Replicates of BxPC3 (red) and BxGR-360C (green) co-culture spheroids (3:1 ratio).
Ian I. Cardle (12646922), Brian J. Kirby (167953), Fredrik I. Thege (12646919), Conor N. Gruber (12646925), Sophie Cong (12646931), Megan J. Siemann (12646928), Katharina Wittmann (11990029), Justin Love (12646934)   +7 more
core   +2 more sources

Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward

Frontiers in Molecular Biosciences, 2020
Three-dimensional cell cultures, such as spheroids and organoids, serve as increasingly important models in fundamental and applied research and start to be used for drug screening purposes.
Elina Nürnberg, Elina Nürnberg, Mario Vitacolonna, Julia Klicks, Elena von Molitor, Tiziana Cesetti, Florian Keller, Roman Bruch, Torsten Ertongur-Fauth, Katja Riedel, Paul Scholz, Thorsten Lau, Richard Schneider, Julia Meier, Mathias Hafner, Rüdiger Rudolf   +15 more
doaj   +1 more source

Droplet contact-based spheroid transfer technique as a multi-step assay tool for spheroid arrays

, 2021
Hanging drop plates and low-attachment well plates are suitable for a high throughput screening model of a spheroid, because each drop (or well) contains a single spheroid and the spheroid environment are separated from each other.
Park, Je-Kyun, Kim, Hwisoo, Roh, Hyewon, Kim, Haseong   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Deep Learning for Predicting Spheroid Viability: Novel Convolutional Neural Network Model for Automating Quality Control for Three-Dimensional Bioprinting

Bioengineering
Spheroids serve as the building blocks for three-dimensional (3D) bioprinted tissue patches. When larger than 500 μm, the desired size for 3D bioprinting, they tend to have a hypoxic core with necrotic cells.
Zyva A. Sheikh, Oliver Clarke, Amatullah Mir, Narutoshi Hibino   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response

Frontiers in Bioengineering and Biotechnology, 2020
Glioblastoma (GBM) is a lethal, incurable form of cancer in the brain. Even with maximally aggressive surgery and chemoradiotherapy, median patient survival is 14.5 months.
Hemamylammal Sivakumar, Hemamylammal Sivakumar, Hemamylammal Sivakumar, Mahesh Devarasetty, David E. Kram, David E. Kram, Roy E. Strowd, Roy E. Strowd, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal   +14 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source