Results 51 to 60 of about 67,710 (307)

Evaluation of the Properties and Osteogenic Potential of a Novel Scaffold-Free Material, Spheroid Blocks Comprising Fused Spheroids of Human Periodontal Ligament Mesenchymal Stem Cells

Stem Cells International
Periodontal ligament stem cell spheroids are reportedly valuable for tissue regeneration; however, their application in vivo requires the use of a scaffold, which may raise safety concerns.
Kotaro Sano, Satoru Onizuka, Takenori Suga, Yuichiro Oka, Sho Hironaka, Kohji Nakazawa, Hisataka Kondo, Kazunori Hamamura, Wataru Ariyoshi, Michihiko Usui   +9 more
doaj   +1 more source

Heterotypic 3D Model of Breast Cancer Based on Tumor, Stromal and Endothelial Cells: Cytokines Interaction in the Tumor Microenvironment

Cells
The recreation of the tumor microenvironment remains a significant challenge in the development of experimental cancer models. The present study constitutes an investigation into the interconnection between tumor, endothelial and stromal cells in ...
Anastasia Leonteva, Alina Kazakova, Ekaterina Berezutskaya, Anna Ilyina, David Sergeevichev, Sergey Vladimirov, Maria Bogachek, Igor Vakhrushev, Pavel Makarevich, Vladimir Richter, Anna Nushtaeva   +10 more
doaj   +1 more source

Advanced spheroidal degeneration [PDF]

Digital Journal of Ophthalmology, 2019
Spheroidal degeneration, involving the cornea and/or the conjunctiva, is characterized by amber-colored homogeneous, translucent spherules in the corneal stroma, Bowman’s membrane, and subepithelium. The condition has a higher prevalence in areas with extreme temperatures, low humidity, high wind, and presence of sand.
Abdelrahman M, Elhusseiny, Reem H, El Sheikh, Emery, Jamerson, Islam Y, Swaify, Ahmed B, Araissi, Abdelaziz A, Saad   +5 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Duo of Osteogenic and Angiogenic Differentiation in ADSC-Derived Spheroids

Frontiers in Cell and Developmental Biology, 2021
Bone formation during embryogenesis is driven by interacting osteogenesis and angiogenesis with parallel endothelial differentiation. Thence, all in vitro bioengineering techniques are aimed at pre-vascularization of osteogenic bioequivalents to provide ...
Anastasiya A. Gorkun, Anastasiya A. Gorkun, Daria P. Revokatova, Daria P. Revokatova, Irina M. Zurina, Irina M. Zurina, Denis A. Nikishin, Denis A. Nikishin, Polina Y. Bikmulina, Peter S. Timashev, Peter S. Timashev, Peter S. Timashev, Peter S. Timashev, Anastasiya I. Shpichka, Nastasia V. Kosheleva, Nastasia V. Kosheleva, Nastasia V. Kosheleva, Tamara D. Kolokoltsova, Irina N. Saburina   +18 more
doaj   +1 more source

Immunostaining of invading spheroid.

, 2022
a) Spheroid fixed after 3 days in an aligned collagen gel in a microfluidic channel. The images show brightfield (BF), YAP immuno-staining (YAP, yellow), the nuclei stained with Hoechst 33342 (cell nuclei, blue), and a composite of YAP and Hoechst.
Manuel S. Brugger (12174360), Hanna Engelke (1339875), Florian Geiger (7861298), Christoph Westerhausen (3495677), Lukas G. Schnitzler (12174357)   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The spheroidizing tendency and spheroidization mechanism of 75Cr1 steel [PDF]

MATEC Web of Conferences, 2018
Spheroidization annealing process was carried out on 75Cr1 steel after cold rolling. Using TEM, SEM and image analysis software Image-Pro Plus 6.0, the effects of cold rolling and spheroidization processes on microstructure and mechanical properties were analyzed.
Huo Jiping, Zhou Chong, Wang Hua
openaire   +2 more sources

Spheroid-Based Approach to Assess Tissue Relevance of Analysis of Dispersed-Settled Tissue Cells by Cytometry of Reaction Rate Constant

, 2020
File main pdf file (CRRC of dispersed-settled spheroidal cells.pdf) describes experimental results and their interpretation for a study of tissue relevance of analyses of dispersed-settled tissues cells by Cytometry of Reaction Rate Constant (CRRC). CRRC
Chun Peng (5721759), Laurie E. Ailles (5721760), Vasilij Koshkin (5721756), Sergey Krylov (6644090), Mariana Bleker de Oliveira (8731595), Allan Covens (8731597), Geoffrey Liu (5721835)   +6 more
core   +1 more source