Results 71 to 80 of about 67,710 (307)
Current OncologyWe aimed to evaluate the therapeutic potential of crizotinib, a broad-spectrum tyrosine kinase inhibitor against bladder cancer (BC) cells, based on a three-dimensional (3D) cell culture system.
Byeongdo Song +4 more
doaj +1 more source
Cold storage of porcine hepatocyte spheroids for spheroid bioartificial liver [PDF]
Xenotransplantation, 2019 AbstractBackground and aimsCell‐based therapies for liver disease such as bioartificial liver rely on a large quantity and high quality of hepatocytes. Cold storage was previously shown to be a better way to preserve the viability and functionality of hepatocytes during transportation rather than freezing, but this was only proved at a lower density of
Yi Li +6 more
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, 2015 Cells were plated at a density of 100 cells in total 100ul in 96-well plates and cultured for 14 days. Cells were then stained with MTT, and spheroids were counted manually. Each experiment was performed in triplicate.
Caimiao Wei (174586) +12 more
core +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez +9 more
wiley +1 more source
Nanofabrication of Nonfouling Surfaces for Micropatterning of Cell and Microtissue
Molecules, 2010 Surface engineering techniques for cellular micropatterning are emerging as important tools to clarify the effects of the microenvironment on cellular behavior, as cells usually integrate and respond the microscale environment, such as chemical and ...
Hidenori Otsuka
doaj +1 more source
Development of a stem cell spheroid‐laden patch with high retention at skin wound site
Bioengineering & Translational Medicine, 2022 Mesenchymal stem cells such as human adipose tissue‐derived stem cells (hADSCs) have been used as a representative therapeutic agent for tissue regeneration because of their high proliferation and paracrine factor‐secreting abilities.
Gun‐Jae Jeong +11 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Dwarf spheroidals in MOND [PDF]
Monthly Notices of the Royal Astronomical Society, 2008 We take the line of sight velocity dispersions as functions of radius for 8 Milky Way dwarf spheroidal galaxies and use Jeans analysis to calculate the mass-to-light ratios (M/L) in Modified Newtonian Dynamics (MOND). Using the latest structural parameters, distances and variable velocity anisotropy, we find 6/8 dwarfs have sensible M/L using only the ...
openaire +2 more sources