Results 41 to 50 of about 130,558 (351)

Biofabrication of prevascularized spheroids for bone tissue engineering by fusion of microvascular fragments with osteoblasts

Frontiers in Bioengineering and Biotechnology
IntroductionSpheroids are promising building blocks for scaffold-free bone tissue engineering. Their rapid vascularization is of major importance to guarantee their survival after transplantation.
Selina Wrublewsky, Jessica Schultz, Jessica Schultz, Tekoshin Ammo, Caroline Bickelmann, Wolfgang Metzger, Thomas Später, Tim Pohlemann, Michael D. Menger, Matthias W. Laschke   +9 more
doaj   +1 more source

The Duo of Osteogenic and Angiogenic Differentiation in ADSC-Derived Spheroids

Frontiers in Cell and Developmental Biology, 2021
Bone formation during embryogenesis is driven by interacting osteogenesis and angiogenesis with parallel endothelial differentiation. Thence, all in vitro bioengineering techniques are aimed at pre-vascularization of osteogenic bioequivalents to provide ...
Anastasiya A. Gorkun, Anastasiya A. Gorkun, Daria P. Revokatova, Daria P. Revokatova, Irina M. Zurina, Irina M. Zurina, Denis A. Nikishin, Denis A. Nikishin, Polina Y. Bikmulina, Peter S. Timashev, Peter S. Timashev, Peter S. Timashev, Peter S. Timashev, Anastasiya I. Shpichka, Nastasia V. Kosheleva, Nastasia V. Kosheleva, Nastasia V. Kosheleva, Tamara D. Kolokoltsova, Irina N. Saburina   +18 more
doaj   +1 more source

The role of inertia for the rotation of a nearly spherical particle in a general linear flow [PDF]

, 2015
We analyse the angular dynamics of a neutrally buoyant nearly spherical particle immersed in a steady general linear flow. The hydrodynamic torque acting on the particle is obtained by means of a reciprocal theorem, regular perturbation theory exploiting
B. Mehlig, E. J. Hinch, F. Candelier, F. Lundell, H. Lamb, H. Lorentz, J. Einarsson, J. Happel, J.-R. Angilella, M. Abramowitz, S. Kim, W. E. Byerly   +11 more
core   +2 more sources

Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward

Frontiers in Molecular Biosciences, 2020
Three-dimensional cell cultures, such as spheroids and organoids, serve as increasingly important models in fundamental and applied research and start to be used for drug screening purposes.
Elina Nürnberg, Elina Nürnberg, Mario Vitacolonna, Julia Klicks, Elena von Molitor, Tiziana Cesetti, Florian Keller, Roman Bruch, Torsten Ertongur-Fauth, Katja Riedel, Paul Scholz, Thorsten Lau, Richard Schneider, Julia Meier, Mathias Hafner, Rüdiger Rudolf   +15 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Deep Learning for Predicting Spheroid Viability: Novel Convolutional Neural Network Model for Automating Quality Control for Three-Dimensional Bioprinting

Bioengineering
Spheroids serve as the building blocks for three-dimensional (3D) bioprinted tissue patches. When larger than 500 μm, the desired size for 3D bioprinting, they tend to have a hypoxic core with necrotic cells.
Zyva A. Sheikh, Oliver Clarke, Amatullah Mir, Narutoshi Hibino   +3 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response

Frontiers in Bioengineering and Biotechnology, 2020
Glioblastoma (GBM) is a lethal, incurable form of cancer in the brain. Even with maximally aggressive surgery and chemoradiotherapy, median patient survival is 14.5 months.
Hemamylammal Sivakumar, Hemamylammal Sivakumar, Hemamylammal Sivakumar, Mahesh Devarasetty, David E. Kram, David E. Kram, Roy E. Strowd, Roy E. Strowd, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal   +14 more
doaj   +1 more source

Supermassive Black Hole Mass Functions at Intermediate Redshifts from Spheroid and AGN Luminosity Functions

, 2005
Redshift evolution of supermassive black hole mass functions (BHMFs) is investigated up to z ~ 1. BHMFs at intermediate redshifts are calculated in two ways.
Aller, Bell, Bell, Bower, Cavaliere, Cross, Ferrarese, Fioc, Gebhardt, Girardi, Heckman, Im, Kawaguchi, Kochanek, Kodama, Kodama, Kouji Ohta, Magorrian, Marconi, Marconi, Marzke, McLure, McLure, Merloni, Merloni, Merritt, Naoyuki Tamura, Peletier, Robertson, Schweizer, Shankar, Shields, Small, Stoughton, Tamura, Terlevich, Treu, Ueda, Willott, Wolf, Yoshihiro Ueda, Ziegler   +41 more
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source