Results 41 to 50 of about 68,956 (338)
Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes
Molecules, 2022 Ceramides belong to the sphingolipid family and represent the central hub of the sphingolipid network. In obesity, oversupply of saturated fatty acids including palmitate raises ceramide levels which can be detrimental to cells.
Wen-hong Li
doaj +1 more source
Flagellar membrane association via interaction with lipid rafts [PDF]
, 2009 The eukaryotic flagellar membrane has a distinct composition from other domains of the plasmalemma. Our work shows that the specialized composition of the trypanosome flagellar membrane reflects increased concentrations of sterols and saturated fatty ...
Cieslak, John A. +6 more
core +2 more sources
Frontiers in Oncology, 2021 Prostate cancer is the second most prevalent malignancy worldwide. In the early stages, the development of prostate cancer is dependent on androgens. Over time with androgen deprivation therapy, 20% of prostate cancers progress to a castration-resistant ...
I Gusti Md Gde Surya C. Trapika +18 more
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Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]
, 2010 Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
A Kamleh +63 more
core +6 more sources
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis [PDF]
, 2019 Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to ...
Becker, Katrin A. +9 more
core +1 more source
Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts
Journal of Lipid Research, 2021 Hereditary sensory neuropathy type 1 (HSAN1) is a rare axonopathy, characterized by a progressive loss of sensation (pain, temperature, and vibration), neuropathic pain, and wound healing defects.
Gergely Karsai +5 more
doaj +1 more source
New strategic insights into managing fungal biofilms [PDF]
, 2015 Fungal infections have dramatically increased in the last decades in parallel with an increase of populations with impaired immunity, resulting from medical conditions such as cancer, transplantation or other chronic diseases.
Borghi, Elisa +6 more
core +3 more sources
Sphingolipids and cell death [PDF]
Apoptosis, 2007 Sphingolipids (SLs) have been considered for many years as predominant building blocks of biological membranes with key structural functions and little relevance in cellular signaling. However, this view has changed dramatically in recent years with the recognition that certain SLs such as ceramide, sphingosine 1-phosphate and gangliosides, participate
Félix M. Goñi +4 more
openaire +4 more sources
Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]
, 2015 Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola +8 more
core +2 more sources
Whales, lifespan, phospholipids, and cataracts[S]
Journal of Lipid Research, 2017 This study addresses the question: why do rats get cataracts at 2 years, dogs at 8 years, and whales do not develop cataracts for 200 years? Whale lens lipid phase transitions were compared with the phase transitions of other species that were ...
Douglas Borchman +2 more
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