Results 181 to 190 of about 35,165 (291)

Sphingosine‐1‐Phosphate Receptor 1 Regulates Competition Dependent Astrocyte Morphogenesis and Tiling in Murine Cortex

Glia, Volume 74, Issue 8, August 2026.
Neuronal contact‐induced expression of S1PR1 in astrocytes is regulated by JAK‐STAT3 signaling. Astrocytic S1PR1 modulates cortical astrocyte morphogenesis. Astrocytic S1PR1 regulates astrocyte territorial overlap/tiling in a competition dependent manner.
Jean Patrick M. Gonzales, Connor Tuck, Surya Chandra Rao Thumu, Soha Munir, Jaden Harris, Hunain (Zeik) Tariq, Paul Marcelli, Oscar Dominguez, Kaviya Suriyakumar Anbazagan, Sandeep K. Singh   +9 more
wiley   +1 more source

GBA3 as a regulator of sphingolipid metabolism in the progression of hepatocellular carcinoma. [PDF]

J Gastrointest Oncol
Wang X, Li L, Sun T, Qiu Z.
europepmc   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

Revealing sphingolipid metabolism genes as biomarkers for the diagnosis of invasive pituitary adenomas in silico and in vivo. [PDF]

Eur J Med Res
Xu ZJ, Zhang RT, Tian N, Gan N.
europepmc   +1 more source

Exercise‐Induced Extracellular Vesicles as Mediators of Mitochondrial Biogenesis and Insulin Sensitivity in Metabolic Adaptation

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Exercise stimulates the release of extracellular vesicles from metabolically active tissues. These vesicles transport regulatory cargos, including microRNAs, proteins, lipids, and metabolites, to target organs such as skeletal muscle, adipose tissue, liver, and vascular tissues.
Jian Wang, Lei Wu
wiley   +1 more source

Human Milk Oligosaccharide LNnT Attenuates Colonic Barrier Dysfunction and Associated Cognitive Impairment via Modulating Sphingolipid Metabolism and Gut Microbiota. [PDF]

Molecules
Wang M, Zhu L, Liao J, Bao L, Li H, Deng Z, Li J, Zheng L, Zhang B.   +8 more
europepmc   +1 more source

Neuroprotective Effects of Biosynthetic d‐Calcium Pantothenate and Cyanocobalamin Against MPTP‐Induced Parkinsonism via Microbiota Modulation, Metabolic Homeostasis Restoration, and Endoplasmic Reticulum Stress Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Biosynthetic D‐calcium pantothenate and cyanocobalamin alleviate MPTP‐induced Parkinsonism in mice by modulating gut microbiota, restoring metabolic homeostasis, and inhibiting Endoplasmic Reticulum Stress. ABSTRACT Vitamin B5 (VB5) and Vitamin B12 (VB12) are essential micronutrients widely distributed in functional foods, yet their neuroprotective ...
Yaru Chen, Shaohui Zhu, Yajie Ruan, Kaiqi Zheng, Jing Wang, Qianqian Guan, Tao Xiong   +6 more
wiley   +1 more source

Identification and validation of a sphingolipid metabolism-related prognostic signature for predicting prognosis and immune microenvironment-related characteristics in ovarian cancer. [PDF]

Transl Cancer Res
Lian X, Chang H, Yang Y, Guo Y, Zhang L, Jia X.   +5 more
europepmc   +1 more source

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, Volume 159, Issue 1, Page 257-268, 1 July 2026.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

SMPD1-mediated sphingolipid metabolism dysregulation in predicting and preventing in-stent restenosis of coronary heart disease patients. [PDF]

J Pharm Anal
Meng W, Sha Y, Zhong-Ga CR, Pan H, Zhai X, Zhen P, Tong HHY, Lao EPL, Zhang H, Yang W, Cui S, Song X, Li K.   +12 more
europepmc   +1 more source