Results 201 to 210 of about 908,827 (288)

Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction. [PDF]

Nat Commun
Rodríguez-López S, Pérez-Rodríguez M, Badreddine A, Gaspar RC, Novaes Morgan HJ, Sakuma I, von Alvensleben GVG, Alonso-Calleja A, Everts SPA, Suter NE, Benegiamo G, Goepfert C, de Brot S, Villalba JM, Shulman GI, Schoonjans K, Auwerx J.   +16 more
europepmc   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, Volume 101, Issue 5, Page 2103-2118, October 2026.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

GBA3 as a regulator of sphingolipid metabolism in the progression of hepatocellular carcinoma. [PDF]

J Gastrointest Oncol
Wang X, Li L, Sun T, Qiu Z.
europepmc   +1 more source

A Rare Case of Fatty Acid Hydroxylase‐Associated Neurodegeneration in a Pakistani Boy With a Homozygous FA2H Variant

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Fatty acid hydroxylase‐associated neurodegeneration (FAHN) is an ultra‐rare neurological disorder caused by a mutation in the FA2H gene. Defective production of this gene leads to abnormal myelin formation, which subsequently causes neurodegeneration and brain iron accumulation.
Araj Naveed Siddiqui, Yamna Naveed Siddiqui, Noor ul Huda Abbasi, Raman Kumar, Hermann Yokolo   +4 more
wiley   +1 more source

An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway. [PDF]

J Lipid Res
Ghandour B, Amin S, Medatwal N, Lee AH, Yu GQ, Resnick AE, Chiappone SB, Clarke CJ, Canals D, Hannun YA, Luberto C.   +10 more
europepmc   +1 more source

Integrated Multi‐Omics and Single‐Cell Analyses Implicate NOX4 as an Icariin‐Associated Oxidative Stress Regulatory Node in Gastric Cancer

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
NOX4 represents a candidate icariin‐associated regulatory node in gastric cancer and may contribute to the cellular response to icariin through redox‐related signaling. ABSTRACT Icariin, a prenylated flavonoid glycoside from Epimedium species, is a representative dietary polyphenol with antioxidant, anti‐inflammatory, and antitumor properties.
Na Liang, Junyan Li, Zuchao Luo, Zijuan Song, Liyuan Zhang, Chengyi Zou, Chunming Li, Bochen Pan, Jiawei Yang   +8 more
wiley   +1 more source

Revealing sphingolipid metabolism genes as biomarkers for the diagnosis of invasive pituitary adenomas in silico and in vivo. [PDF]

Eur J Med Res
Xu ZJ, Zhang RT, Tian N, Gan N.
europepmc   +1 more source

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Drug Resistance: The Role of Sphingolipid Metabolism. [PDF]

Int J Mol Sci
Zhakupova A, Zeinolla A, Kokabi K, Sergazy S, Aljofan M.   +4 more
europepmc   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source