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The metabolism and function of sphingolipids and glycosphingolipids
Cellular and Molecular Life Sciences, 2007Sphingolipids and glycosphingolipids are emerging as major players in many facets of cell physiology and pathophysiology. We now present an overview of sphingolipid biochemistry and physiology, followed by a brief presentation of recent advances in translational research related to sphingolipids. In discussing sphingolipid biochemistry, we focus on the
S, Lahiri, A H, Futerman
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Yeast sphingolipids: metabolism and biology
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Sphingolipids have recently emerged as important bioactive molecules in addition to being critical structural components of cellular membranes. These molecules have been implicated in regulating cell growth, differentiation, angiogenesis, apoptosis, and senescene.
Lina M, Obeid +2 more
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Sphingolipid Metabolism and Analysis in Metabolic Disease
2011Sphingolipids are an important class of structural and signaling molecules within the cell. As sphingolipids have been implicated in the development and pathogenesis of insulin resistance and the metabolic syndrome, it is important to understand their regulation and metabolism.
Sarah E, Brice, L Ashley, Cowart
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Sphingolipid Metabolism inBacteroideaceae
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1975The lipid composition of the anaerobic Bacteroides thetaiotaomikron has been analyzed. Sphingomyelin, ceramide phosphinicoethanolamine, free even-numbered and branched chain sphingosine bases and ceramide represented about 50% of the total lipid extract. The main ester phospholipid was phosphatidylethanolamine.
W, Stoffel, K, Dittmar, R, Wilmes
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Regulation of lipid metabolism by sphingolipids
2008Sphingolipids, together with phospholipids and cholesterol are key components of membrane lipid bilayers, contribute to specialized membrane domains called rafts and function as signaling molecules. Sphingolipids have been recognized to exert a distinct role in the post-transcriptional regulation of the sterol-regulatory element binding proteins ...
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Plant Sphingolipid Metabolism and Function
2016Sphingolipids, a once overlooked class of lipids in plants, are now recognized as abundant and essential components of plasma membrane and other endomembranes of plant cells. In addition to providing structural integrity to plant membranes, sphingolipids contribute to Golgi trafficking and protein organizational domains in the plasma membrane ...
Kyle D, Luttgeharm +2 more
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Virus infection and sphingolipid metabolism
Antiviral ResearchCellular sphingolipids have vital roles in human virus replication and spread as they are exploited by viruses for cell entry, membrane fusion, genome replication, assembly, budding, and propagation. Intracellular sphingolipid biosynthesis triggers conformational changes in viral receptors and facilitates endosomal escape.
Jun Dai +7 more
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Disorders of Sphingolipid Metabolism
1973The last 10 years have witnessed dramatic and accelerating progress in investigations of the group of genetic disorders commonly categorized as lipid storage diseases. Except for a few diseases, including Refsum’s disease and Wolman’s disease, most of the lipid storage diseases involve inborn errors of metabolism of a particular type of complex lipids ...
Kunihiko Suzuki, Kinuko Suzuki
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Sphingolipids in hepatic metabolism
Nature Reviews Gastroenterology & Hepatology, 2022openaire +2 more sources
Enzymes of sphingolipid metabolism as transducers of metabolic inputs
Biochemical Society TransactionsSphingolipids (SLs) constitute a discrete subdomain of metabolism, and they display both structural and signaling functions. Accumulating evidence also points to intimate connections between intermediary metabolism and SL metabolism. Given that many SLs exhibit bioactive properties (i.e. transduce signals), these raise the possibility that an important
Fabiola N. Velazquez +3 more
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