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Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
Metabolic reprogramming in cancer stem cells: lipid flux, mitochondrial plasticity, and therapeutic resistance. Lipid metabolism in CSCs: de novo lipogenesis, CD36 uptake, FAO, lipid droplets, and membrane remodeling. Mitochondrial dynamics in CSC survival: fusion, fission, mitophagy, OXPHOS switching, and ROS regulation.
Daniel Ejim Uti, Esther Ugo Alum, Josephine E. Egbung, Zuhair M. Mohammedsaleh, Manpreet Kaur, Kranti Kiran Reddy Ealla   +5 more
wiley   +1 more source

Identification and validation of ANXA3 and SOCS3 as biomarkers for acute myocardial infarction related to sphingolipid metabolism. [PDF]

Hereditas
Sun L, He L, Pan HH, Zhai CL.
europepmc   +1 more source

Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation. [PDF]

mBio
Salisch F, Schumacher F, Gärtner U, Kleuser B, Ziebuhr J, Müller-Ruttloff C.   +5 more
europepmc   +1 more source

A research perspective on sphingolipid metabolism and myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

Neural Regen Res
Xiao J.
europepmc   +1 more source

Editorial: The role of sphingolipid metabolism in endocrine diseases. [PDF]

Front Endocrinol (Lausanne)
Li C, Li G.
europepmc   +1 more source

Lipid Dysregulation in Sebaceous Gland Disorders and the Impact of Sphingolipid Metabolism on Acne Pathogenesis. [PDF]

Cureus
Miner K, Murphy R, Steiss S, Burian M, Welp H, Loperfito A, O'Malley A, Misra R, Frasier KM.   +8 more
europepmc   +1 more source

Correction to "Chronic Cerebral Hypoperfusion Aggravates Parkinson's Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism". [PDF]

Oxid Med Cell Longev
europepmc   +1 more source

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Sphingolipid Metabolism in Tumor Cells

Biochemistry (Moscow), 2023
Sphingolipids are a diverse family of complex lipids typically composed of a sphingoid base bound to a fatty acid via amide bond. The metabolism of sphingolipids has long remained out of focus of biochemical studies. Recently, it has been attracting an increasing interest of researchers because of different and often multidirectional effects ...
Pokrovsky Vadim S., Ivanova-Radkevich Veronika I., Kuznetsova Olga M.   +2 more
openaire   +3 more sources

Sphingolipid Metabolism and Metabolic Disease

Advances in Experimental Medicine and Biology, 2022
exaly   +2 more sources

Sphingolipid Metabolism and Atherosclerosis

2013
Atherosclerosis is the major cause of mortality in the developed countries. Although presently known risk factors have some predictive value for the disease, a major part of the variability in this process remains unexplained. It is extremely important to find new approaches for better understanding of the disease and for treating it.
Xian-Cheng, Jiang, Jing, Liu
openaire   +2 more sources