Results 261 to 270 of about 35,165 (291)
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Regulation of lipid metabolism by sphingolipids
2008Sphingolipids, together with phospholipids and cholesterol are key components of membrane lipid bilayers, contribute to specialized membrane domains called rafts and function as signaling molecules. Sphingolipids have been recognized to exert a distinct role in the post-transcriptional regulation of the sterol-regulatory element binding proteins ...
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Virus infection and sphingolipid metabolism
Antiviral ResearchCellular sphingolipids have vital roles in human virus replication and spread as they are exploited by viruses for cell entry, membrane fusion, genome replication, assembly, budding, and propagation. Intracellular sphingolipid biosynthesis triggers conformational changes in viral receptors and facilitates endosomal escape.
Jun Dai +7 more
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Plant Sphingolipid Metabolism and Function
2016Sphingolipids, a once overlooked class of lipids in plants, are now recognized as abundant and essential components of plasma membrane and other endomembranes of plant cells. In addition to providing structural integrity to plant membranes, sphingolipids contribute to Golgi trafficking and protein organizational domains in the plasma membrane ...
Kyle D, Luttgeharm +2 more
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Sphingolipids in hepatic metabolism
Nature Reviews Gastroenterology & Hepatology, 2022openaire +2 more sources
Enzymes of sphingolipid metabolism as transducers of metabolic inputs
Biochemical Society TransactionsSphingolipids (SLs) constitute a discrete subdomain of metabolism, and they display both structural and signaling functions. Accumulating evidence also points to intimate connections between intermediary metabolism and SL metabolism. Given that many SLs exhibit bioactive properties (i.e. transduce signals), these raise the possibility that an important
Fabiola N. Velazquez +3 more
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Disorders of Sphingolipid Metabolism
1973The last 10 years have witnessed dramatic and accelerating progress in investigations of the group of genetic disorders commonly categorized as lipid storage diseases. Except for a few diseases, including Refsum’s disease and Wolman’s disease, most of the lipid storage diseases involve inborn errors of metabolism of a particular type of complex lipids ...
Kunihiko Suzuki, Kinuko Suzuki
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Chemotherapy and Sphingolipid Metabolism
2015It is well established that sphingolipids are crucial signal transducers regulating several cellular processes like growth, proliferation, response to stress, differentiation, senescence, autophagy and apoptosis. The critical role of sphingolipids in cancer initiation, progression, pathogenesis and metastasis has led to an expanding interest in ...
Ushma A. Doshi +4 more
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Disorders of Sphingolipid Metabolism
2000Sphingolipidoses are a subgroup of lysosomal storage disorders. They are characterized by relentless progressive storage in affected organs and concomitant functional impairments. No overall screening procedure for these disorders is available. Their course and appearance, however, are usually characteristic and, together with relevant technical ...
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Sphingolipids and Metabolic Disease
2011Sphingolipid Metabolism and Analysis in Metabolic Disease.- Sphingolipids and Cardiovascular Diseases: Lipoprotein Metabolism, Atherosclerosis and Cardiomyopathy.- Heart Sphingolipids in Health and Disease.- Blood Sphingolipids in Homeostasis and Pathobiology.- Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity.- Sphingolipids and ...
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